Results 61 to 70 of about 91,428 (363)
The FEBS Journal, 2019 Ubiquitin‐conjugating enzyme 2C (UBE2C) is a core ubiquitin‐conjugating enzyme in the ubiquitin–proteasome system that promotes cell cycle progression. Previous studies have indicated that UBE2C mediates tumorigenesis and progression in various cancers ...
Xianxing Wang +7 more
semanticscholar +1 more source
E3 ubiquitin ligases: styles, structures and functions
Molecular Biomedicine, 2021 E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination cascade together with ubiquitin activating enzyme E1 and ubiquitin conjugating enzyme E2.
Quan Yang +3 more
doaj +1 more source
Journal of Biological Chemistry, 2018 Dysregulation of the circadian rhythm is associated with many diseases, including diabetes, obesity, and cancer. Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Arntl or Bmal1) is the only clock gene whose loss disrupts circadian locomotor
Suping Chen +8 more
semanticscholar +1 more source
Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation. [PDF]
PLoS ONE, 2015 The ubiquitin-like modifier HLA-F adjacent transcript 10 (FAT10) directly targets its substrates for proteasomal degradation by becoming covalently attached via its C-terminal diglycine motif to internal lysine residues of its substrate proteins.
Johanna Bialas +2 more
doaj +1 more source
Scientific Reports, 2018 African swine fever virus is the etiological agent of a contagious and fatal acute haemorrhagic viral disease for which there are no vaccines or therapeutic options.
F. Freitas +3 more
semanticscholar +1 more source
Huntingtin Is Ubiquitinated and Interacts with a Specific Ubiquitin-conjugating Enzyme [PDF]
Journal of Biological Chemistry, 1996 Using the yeast two-hybrid system, we have identified a human ubiquitin-conjugating enzyme (hE2-25K) as a protein that interacts with the gene product for Huntington disease (HD) (Huntingtin). This protein has complete amino acid identity with the bovine E2-25K protein and has striking similarity to the UBC-1, -4 and -5 enzymes of Saccharomyces ...
Gang Xia +9 more
openaire +2 more sources
The ubiquitin-proteasome pathway in Huntington's disease. [PDF]
, 2008 The accumulation of mutant protein is a common feature of neurodegenerative disease. In Huntington's disease, a polyglutamine expansion in the huntingtin protein triggers neuronal toxicity.
Finkbeiner, Steven, Mitra, Siddhartha
core +2 more sources
A Subset of Ubiquitin-Conjugating Enzymes Is Essential for Plant Immunity [PDF]
Plant Physiology, 2016 Of the three classes of enzymes involved in ubiquitination, ubiquitin-conjugating enzymes (E2) have been often incorrectly considered to play merely an auxiliary role in the process, and few E2 enzymes have been investigated in plants. To reveal the role of E2 in plant innate immunity, we identified and cloned 40 tomato genes encoding ubiquitin E2 ...
Lirong Zeng +9 more
openaire +3 more sources
Sumoylation silences the plasma membrane leak K+ channel K2P1. [PDF]
, 2005 Reversible, covalent modification with small ubiquitin-related modifier proteins (SUMOs) is known to mediate nuclear import/export and activity of transcription factors.
Butler, Margaret H +4 more
core +1 more source
The ubiquitin system and jasmonate signaling [PDF]
, 2016 The ubiquitin (Ub) system is involved in most, if not all, biological processes in eukaryotes. The major specificity determinants of this system are the E3 ligases, which bind and ubiquitinate specific sets of proteins and are thereby responsible for ...
Goossens, Alain +2 more
core +3 more sources