Results 61 to 70 of about 45,058 (234)

E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1 [PDF]

Nature Structural & Molecular Biology, 2013
OTUB1 is a Lys48-specific deubiquitinating enzyme that forms a complex in vivo with E2 ubiquitin (Ub)-conjugating enzymes including UBC13 and UBCH5. OTUB1 binds E2~Ub thioester intermediates and prevents ubiquitin transfer, thereby noncatalytically inhibiting accumulation of polyubiquitin.
Michael J. Matunis, Xiangbin Zhang, Xiangbin Zhang, Cynthia Wolberger, Cynthia Wolberger, Reuven Wiener, Catherine M. Guzzo, Anthony T DiBello, Anthony T DiBello, Patrick M. Lombardi, Patrick M. Lombardi   +10 more
openaire   +3 more sources

Phenotypic Characterization of the Arabidopsis ufm1 (Ubiquitin Fold Modifier) Gene Involved in Seed Development [PDF]

, 2016
Background and Objective: With the completion of the Arabidopsis genome sequencing, the next challenge is the determination ofgene function. Post-translational modifications of proteins by small polypeptide are implicated in plant growth and development ...
Cornejo, Paula, Masuelli, Ricardo Williams   +1 more
core   +1 more source

Protein‐Like Polymers Targeting Keap1/Nrf2 as Therapeutics for Myocardial Infarction

Advanced Materials, EarlyView.
We describe a Keap1 targeting protein‐like polymer (PLP) which activates Nrf2, an important cytoprotective transcription factor for relieving myocardial infarction‐induced oxidative stress. This PLP increases cell survival in vitro in multiple relevant cardiac cell types and elicits pro‐reparative responses, improving cardiac function in a preclinical ...
Joshua M. Mesfin, Kendal P. Carrow, Alexander Chen, Madeline P. Hopps, JoJo J. Holm, Quincy P. Lyons, Michael B. Nguyen, Jervaughn D. Hunter, Assa Magassa, Elyse G. Wong, Kate Reimold, Sriya N. Paleti, Emily Gardner, Matthew P. Thompson, Colin G. Luo, Xiaoyu Zhang, Karen L. Christman, Nathan C. Gianneschi   +17 more
wiley   +1 more source

Ubiquitin- and ubiquitin-like proteins-conjugating enzymes (E2s) in breast cancer [PDF]

, 2018
Breast cancer is the most common malignancy in women and a significant cause of morbidity and mortality. Sub-types of breast cancer defined by the expression of steroid hormones and Her2/Neu oncogene have distinct prognosis and undergo different ...
Voutsadakis, Ioannis
core  

Posttranslational modifications of proteins in the pathobiology of medically relevant fungi [PDF]

, 2012
Peer reviewedPublisher ...
Brown, Alistair J P, Leach, Michelle D
core   +2 more sources

The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels

Advanced Science, EarlyView.
In breast cancer (BC), NUMB loss of function (LOF) is common and mainly driven by protein hyper‐degradation. The CRL7FBXW8 complex is the E3 ligase responsible for NUMB degradation. Inhibition of CRL7FBXW8 in NUMB‐LOF BC cells restores NUMB levels, and decreases the number of cancer stem cells and tumorigenic ability in vivo. Targeting CRL7FBXW8 offers
Simone Sabbioni, Maria Grazia Filippone, Letizia Amadori, Stefano Confalonieri, Roberta Bonfanti, Stefano Capoano, Ivan Nicola Colaluca, Stefano Freddi, Giovanni Bertalot, Giovanni Fagà, Elisa Zagarrí, Mario Varasi, Rosalind Helen Gunby, Ciro Mercurio, Salvatore Pece, Pier Paolo Di Fiore, Daniela Tosoni   +16 more
wiley   +1 more source

HIC1 suppresses Tumor Progression and Enhances CD8+ T Cells Infiltration Through Promoting GSDMD‐induced Pyroptosis in Gastric Cancer

Advanced Science, EarlyView.
These findings elucidate the innovative role of HIC1 as a transcriptional activator in GC, driving the initiation of pyroptosis and enhancing CD8+ T cell infiltration, which has certain novelty and creative significance. Collectively, targeting HIC1 can present an appealing immunotherapeutic strategy to improve outcomes in GC patients.
Mengjie Kang, Wenqi Du, Lina Ding, Mengdi Wu, Dongsheng Pei   +4 more
wiley   +1 more source

Regulation of p53 by the Ubiquitin-conjugating Enzymes UbcH5B/C in Vivo [PDF]

Journal of Biological Chemistry, 2004
p53 levels are regulated by ubiquitination and 26 S proteasome-mediated degradation. p53 is a substrate for the E3 ligase Mdm2, however, the ubiquitin-conjugating enzymes (E2s) involved in p53 ubiquitination in intact cells have not been defined previously.
Saville, Mark K., Sparks, Alison, Xirodimas, Dimitris P., Wardrop, Julie, Stevenson, Lauren F., Bourdon, Jean-Christophe, Woods, Yvonne L., Lane, David P.   +7 more
openaire   +4 more sources

Role of Ubiquitin-Conjugating Enzyme UBE2C in Gastrointestinal Cancers

Proceedings of Anticancer Research, 2021
Ubiquitin-conjugating enzyme UBE2C is one of the important members of ubiquitin-proteasome pathway (UPP). Amplification and/or overexpression of UBE2C have been reported in many malignancies, and a high expression of UBE2C is associated with poor clinical outcomes.
Qian Wang, Ce Guo, Huiqing Zhang, Zhen Wei, Xing Guo   +4 more
openaire   +3 more sources

Inhibition of Ubc13-mediated ubiquitination by GPS2 regulates multiple stages of B cell development [PDF]

, 2016
Non-proteolytic ubiquitin signaling mediated by Lys63 ubiquitin chains plays a critical role in multiple pathways that are key to the development and activation of immune cells.
Aggarwal, Akira, Allman, Amanda Lopacinski, Anna C. Belkina, Baer, Banerji, Barbara S. Nikolajczyk, Bhoj, Bianchi, Bogdan Tanasa, Branigan, Cardamone, Cardamone, Cariappa, Carly T. Cederquist, Cederquist, Chen, Chen, Cheng, Chow, Chu, Chun, Cilloni, Ciriello, Claudia Lentucci, Compagno, Coornaert, Davis, DeFuria, Dengler, Diederichs, Dunne, Fabris, Fan, Flemming, Giltiay, Guo, Habelhah, Haslinger, Hayden, Ho, Holly E. Johnson, Honma, Horikawa, Ikeda, Iwai, Jakobsson, Jennifer Snyder-Cappione, Jiang, Jiang, Jin, Jin, Juang, Jumaa, Karin, Kato, Katz, Kobayashi, Kotecha, Landmann, Langmead, Lee, Lee, Li, Lino, Liu, M. Dafne Cardamone, Malynn, Marchant, Maspero, Michelle Chan, Minegishi, Moran, Nagy, Notley, Ochiai, Oeckinghaus, Ori, Panda, Pappu, Peng, Peng, Pickart, Pillai, Popovic, Pruneda, Pugh, Pulvino, Qiu, Rickert, Ruland, Saito, Sanyal, Sato, Schmidt-Supprian, Shah, Sherry Prasad, Skaug, Spain, Stefano Monti, Stephens, Stringer, Sun, Sun, Szydlowski, Tavares, Toubal, Touma, Valentina Perissi, Venteclef, Wang, Wasserman, Weigert, Wiener, Witt, Wu, Yamamoto, Yang, Yao, Zhang, Zhang, Zhang   +122 more
core   +1 more source