Results 101 to 110 of about 39,918 (341)

Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis

Advanced Science, EarlyView.
This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche, Raisatun Nisa Sugiyanto, Kira Gür, Alina Krumme, Maxime Le Marois, Angelika Fraas, Aslihan Inal, Mario Huerta, Vanessa Henriques, Eva Eiteneuer, Thomas Albrecht, Alphonse Charbel, Michael T. Dill, Carsten Sticht, Carolina De La Torre, Stefan Pusch, Arianeb Mehrabi, Kai Breuhahn, Junfang Ji, Peter Schirmacher, Benjamin Goeppert, Stephanie Roessler   +21 more
wiley   +1 more source

A Novel Peptide-Based SILAC Method to Identify the Posttranslational Modifications Provides Evidence for Unconventional Ubiquitination in the ER-Associated Degradation Pathway. [PDF]

, 2013
The endoplasmic reticulum-associated degradation (ERAD) pathway is responsible for disposing misfolded proteins from the endoplasmic reticulum by inducing their ubiquitination and degradation.
Anania, Veronica, Bustos, Daisy, COSCOY, Laurent, Kirkpatrick, Donald, Lill, Jennie   +4 more
core   +3 more sources

A human ubiquitin-conjugating enzyme homologous to yeast UBC8.

Journal of Biological Chemistry, 1994
Ubiquitin-conjugating enzymes catalyze the covalent attachment of ubiquitin to cellular substrates. Here we describe the isolation of a novel ubiquitin-conjugating enzyme from human placenta and the cloning of the corresponding cDNA. DNA sequencing revealed that this gene, UbcH2, encodes a protein with significant sequence similarity to yeast UBC8.
Kaiser, P., Seufert, W., Höfferer, L., Kofler, B., Sachsenmaier, C., Herzog, H., Jentsch, S., Schweiger, M., Schneider, R.   +8 more
openaire   +3 more sources

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

In vitro Ubiquitin Dimer Formation Assay

Bio-Protocol, 2017
The process of protein ubiquitination typically consists of three sequential steps to add an ubiquitin (Ub) or Ub chain to a substrate protein, requiring three different enzymes, ubiquitin activating enzyme (E1), ubiquitin conjugating enzyme (E2), and ...
Sheng Wang, Ling Cao, Hong Wang
doaj   +1 more source

Molecular and proteomic analyses highlight the importance of ubiquitination for the stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida albicans [PDF]

, 2011
Peer reviewedPublisher ...
Alonso-Monge, Amerik, Andaluz, Bachmair, Brown, Brown, Brown, Calderone, Care, Cash, Chauhan, Cheng, Ciechanover, Ciechanover, Ciechanover, Dennison, Enjalbert, Enjalbert, Ernst, Finley, Finley, Fradin, Fraser, Friant, Garcia-Sanchez, Gietz, Glotzer, Gow, Hauser, Hershko, Hochstrasser, Hromatka, Hube, Hwang, Hwang, Jentsch, Jentsch, Johnson, Kaiser, Kim, Kolkman, Kunze, Leberer, Leng, Liu, Lo, Lorenz, Lorenz, MacCallum, MacCallum, Madura, Mavor, Mayor, Miller, Murad, Muratani, Nakayama, Nantel, Nicholls, Odds, Ozkaynak, Paiva, Peng, Radivojac, Rechsteiner, Rodaki, Roig, Roig, Roig, Santt, Saville, Sepulveda, Seyfried, Sherman, Shi, Skrzypek, Smith, Stadtman, Staub, Stead, Stevenson, Sudbery, Swoboda, Tagwerker, Tanaka, Thewes, Vizcaino, Walther, Weissman, Werner-Washburne, Wilson, Wimalasena, Wolf, Yin, Zakikhany   +94 more
core   +2 more sources

Chromatin Topology Reconfiguration Orchestrates Thermotolerant Male Fertility via GhAL5 in Cotton

Advanced Science, EarlyView.
This study investigates cotton’s high‐temperature (HT) response using multi‑omics. Dynamic 3D genome changes drive expression bias affecting male fertility. The tolerant line shows controlled chromatin dynamics, while the sensitive line exhibits overactivation.
Yanlong Li, Jing Yang, Weiran Wang, Chunyang Zuo, Liuling Pei, Yizan Ma, Rui Zhang, Yaru Fan, Huanhuan Ma, Yawei Li, Ruizhen Liu, Shuangxia Jin, Longfu Zhu, Jie Kong, Xianlong Zhang, Ling Min   +15 more
wiley   +1 more source

Characterization of the gene expression related to the process of DNA damage tolerance in Schistosoma mansoni

Memorias do Instituto Oswaldo Cruz, 2006
In the course of its complex life cycle, the parasite Schistosoma mansoni need to adapt to distinct environments, and consequently is exposed to various DNA damaging agents.
SH Silva, OS Pereira-Júnior, CS Silva, OM Brigatto, E Macedo, V Rodrigues   +5 more
doaj   +1 more source

Role of the ubiquitin-selective CDC-48/UFD-1/NPL-4 chaperone in DNA replication [PDF]

, 2012
Faithful transmission of genomic information requires tight spatiotemporal regulation of DNA replication factors. Posttranslational modifications, such as ubiquitylation, constitute a fast and effective mechanism to control such complex protein function.
Franz, André
core  

UBE2QL1 is Disrupted by a Constitutional Translocation Associated with Renal Tumor Predisposition and is a Novel Candidate Renal Tumor Suppressor Gene [PDF]

, 2013
Investigation of rare familial forms of renal cell carcinoma (RCC) has led to the identification of genes such as VHL and MET that are also implicated in the pathogenesis of sporadic RCC. In order to identify a novel candidate renal tumor suppressor gene,
Banks, RE, Brown, M, Clarke, N, Gribble, SM, Hodgson, S, Maher, ER, Morris, MR, Prigmore, E, Ricketts, CJ, Skytte, AB, Turnell, AS, Wake, NC, Woodward, ER   +12 more
core   +2 more sources