Results 111 to 120 of about 39,918 (341)

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Viral hijacking of cellular ubiquitination pathways as an anti-innate immunity strategy. [PDF]

, 2006
International audienceViruses are obligate parasites of host cells. Virus-host coevolution has selected virus for growth despite antiviral defenses set up by hosting cells and organisms. Ubiquitin conjugation onto proteins, through a cascade of reactions
Chen, Mingzhou, Gerlier, Denis
core   +3 more sources

SUMO modification of the ubiquitin-conjugating enzyme E2-25K

Nature Structural & Molecular Biology, 2005
Post-translational modification with small ubiquitin-related modifier (SUMO) alters the function of many proteins, but the molecular mechanisms and consequences of this modification are still poorly defined. During a screen for novel SUMO1 targets, we identified the ubiquitin-conjugating enzyme E2-25K (Hip2).
Pichler, A., Knipscheer, P., Oberhofer, E., van Dijk, W., Körner, R., Olsen, J., Jentsch, S., Melchior, F., Sixma, T.   +8 more
openaire   +5 more sources

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. [PDF]

, 2014
Unlike the other MAP3Ks, MEKK1 (encoded by Map3k1) contains a PHD motif. To understand the role of this motif, we have created a knockin mutant of mouse Map3k1 (Map3k1(m) (PHD)) with an inactive PHD motif.
Anwar, Saba, Charlaftis, Nikolaos, Gallagher, Ewen, Karin, Michael, Suddason, Tesha, Wu, Xuefeng   +5 more
core   +2 more sources

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

Advanced Science, EarlyView.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis   +11 more
wiley   +1 more source

Regulation of SUMO Modification [PDF]

, 2007
The small ubiquitin related modifier SUMO is a posttranslational modifier that functions in a wide range of cellular processes like intracellular transport, cell cycle regulation, DNA repair and regulation of transcription.
Knipscheer, P.M. (Puck Maria)
core   +1 more source

How ubiquitination regulates the TGF-β signalling pathway: New insights and new players [PDF]

, 2011
Ubiquitination of protein species in regulating signal transduction pathways is universally accepted as of fundamental importance for normal development, and defects in this process have been implicated in the progression of many human diseases.
Bai, Bengoechea-Alonso, Bernassola, Chen, Chen, Chen, Chiu, Ciechanover, Ciehanover, Coccetti, Cook, Cook, Corcoran, Dunn, Ebisawa, Fang, Finley, Flasza, Foot, Foster, Fukuchi, Fukuchi, Fuxe, Gao, Gao, Gazdoiu, Grenfell, Groettrup, Guedat, Haldeman, Handley-Gearhart, Hayashi, He, Hjerpe, Ho, Huang, Huang, Huang, Inoue, Jin, Kang, Kasanov, Kavsak, Kerscher, Koinuma, Komuro, Kuratomi, Li, Liao, Lin, Liu, Liu, Lu, Maddika, Miyazawa, Moren, Mukhopadhyay, Mund, Murata, Nakamura, Nakao, Ogunjimi, Orban, Pelzer, Petroski, Pickart, Pirozzi, Putters, Raikwar, Sadowski, Schmierer, Seo, Shook, Soond, Soond, Stephen, Summers, Sun, Sun, Suzuki, Tajima, Tatematsu, Thrower, Walden, Wan, Wan, Wan, Wendt, Wiesner, Xie, Xu, Xu, Zhang, Zhang, Zhu, Zou   +95 more
core   +1 more source

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

Regulation of biological processes by ubiquitin ligases: a focus on the Pagano Lab’s contribution

Frontiers in Cell and Developmental Biology
Protein homeostasis depends on many fundamental processes including mRNA synthesis, translation, post-translational modifications, and proteolysis.
Philipp Kaldis, Philipp Kaldis, Lisa A. Porter, Lisa A. Porter   +3 more
doaj   +1 more source