Results 161 to 170 of about 63,885 (332)
The ubiquitin–proteasome system: A potential target for the MASLD
Metabolic dysfunction-associated steatotic liver disease (MASLD), the most prevalent chronic liver condition globally, lacks adequate and effective therapeutic remedies in clinical practice.
Yue Liu+9 more
doaj
Association of human ubiquitin-conjugating enzyme CDC34 with the mitotic spindle in anaphase [PDF]
Françoise Reymond+2 more
openalex +1 more source
Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies
Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel+10 more
wiley +1 more source
NRF2 signalling in cytoprotection and metabolism
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami+4 more
wiley +1 more source
Phosphorylation of the Human Ubiquitin-conjugating Enzyme, CDC34, by Casein Kinase 2 [PDF]
Karen Block+2 more
openalex +1 more source
Abstract Autonomic nerves are crucial in cardiac function and pathology. However, data on the distribution of cholinergic and noradrenergic nerves in normal and pathologic human hearts is lacking. Nonfailing donor hearts were pressure‐perfusion fixed, imaged, and dissected. Left ventricular cardiomyopathy samples were also obtained.
Peter Hanna+15 more
wiley +1 more source
Identification of molecular determinants required for interaction of ubiquitin‐conjugating enzymes and RING finger proteins [PDF]
Gustavo Martínez-Noël+2 more
openalex +1 more source