BMEMat, EarlyView.This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan +12 more
wiley +1 more source
The Ubiquitin-Conjugating Enzyme Rad6 (Ubc2) Is Required for Silencing in Saccharomyces cerevisiae
, 1997 Hanhua Huang +4 more
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Gene expression in HCV-associated HCC-identification of an upregulated gene encoding a protein related to ubiquitin conjugating enzyme [PDF]
, 2001 Ghada El-Nady
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Targeting MAN1B1 potently enhances bladder cancer antitumor immunity via deglycosylation of CD47
Cancer Communications, EarlyView.Abstract Background Only a few bladder cancer patients benefit from anti‐programmed cell death protein 1/programmed cell death ligand 1 immunotherapy. The cluster of differentiation 47 (CD47) plays an important role in tumor immune evasion. CD47 is a highly glycosylated protein, however, the mechanisms governing CD47 glycosylation and its potential ...
Jie Zhang +20 more
wiley +1 more source
Individual point mutations in two ERAD E2 ubiquitin-conjugating enzymes do not affect Caenorhabditis elegans spontaneous reversal frequency. [PDF]
MicroPubl Biol, 2020 Oswald M, Hulsey-Vincent H, Dahlberg CL.
europepmc +1 more source
Degradation Signals Recognized by the Ubc6p-Ubc7p Ubiquitin-Conjugating Enzyme Pair
, 2000 Tamar Gilon +2 more
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Two Ubiquitin-Conjugating Enzymes, Rhp6 and UbcX, Regulate Heterochromatin Silencing in Schizosaccharomyces pombe [PDF]
, 2002 Eun Shik Choi +4 more
openalex +1 more source
Ubiquitination in cancer: mechanisms and therapeutic opportunities
Cancer Communications, EarlyView.Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu +7 more
wiley +1 more source
Arabidopsis Ubiquitin-Conjugating Enzymes UBC7, UBC13, and UBC14 Are Required in Plant Responses to Multiple Stress Conditions. [PDF]
Plants (Basel), 2020 Feng H, Wang S, Dong D, Zhou R, Wang H.
europepmc +1 more source
Isolation of tobacco ubiquitin‐conjugating enzyme cDNA in a yeast two‐hybrid system with tobacco ERF3 as bait and its characterization of specific interaction [PDF]
, 2003 Tomotsugu Koyama +5 more
openalex +1 more source