Results 191 to 200 of about 63,885 (332)

In Vivo Biosynthesis and Direct Incorporation of Non‐Canonical Amino Acids into Proteins

open access: yesChemBioChem, Accepted Article.
Autonomous cells are engineered biological systems capable of biosynthesising and directly incorporating non‐canonical amino acids (ncAAs) into proteins. These systems have the potential to extend the applicability of the genetic code to enable large‐scale fermentative production of proteins carrying ncAAs.
Ivana Drienovska   +2 more
wiley   +1 more source

The N-terminal extension of UBE2E ubiquitin-conjugating enzymes limits chain assembly.

open access: yesJournal of Molecular Biology, 2013
Frances-Rose Schumacher   +2 more
semanticscholar   +1 more source

Internal Ubiquitin Electrophiles for Covalent Trapping and Inhibition of Deubiquitinases

open access: yesChemBioChem, Accepted Article.
The ubiquitin (Ub) system governs vital cellular processes in eukaryotic biology through an intricate network of Ub‐protein interactions. While semisynthetic C‐terminal Ub electrophiles (UbEs) are widely used to study Ub transfer and deubiquitinase (Dub) activity, they are limited to probing the active site while leaving other functionally important ...
Chittaranjan Das   +7 more
wiley   +1 more source

Advancing the Exploration of the Ubiquitin‐like Protein FUBI with Synthetic Chemical Tools

open access: yesChemBioChem, EarlyView.
This study unveils a novel synthetic platform by solid‐phase peptide synthesis for generating FUBI‐based chemical tools to investigate FUBIylation, a poorly understood ubiquitin‐like signaling process linked to cancer. By employing these innovative probes, we uncover novel FUBI interactors, paving the way for transformative insights into FUBI biology ...
Francesca D’Amico   +8 more
wiley   +1 more source

Expert Perspective: Hematologic Malignancies and Vasculitis

open access: yes
Arthritis &Rheumatology, EarlyView.
Michelle L. Robinette, Hetty E. Carraway
wiley   +1 more source

Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function

open access: yesEuropean Journal of Heart Failure, EarlyView.
Improving clinical translation of mitoprotective therapies. 31P MRI, phosphorus‐31 magnetic resonance imaging; hiPSC‐CM, human‐induced pluripotent stem cell‐derived cardiomyocyte; IHD, ischaemic heart disease. Abstract Acute myocardial infarction (MI) remains a major cause of death and disability worldwide.
Melanie Paillard   +29 more
wiley   +1 more source

The Ubiquitin-Conjugating DNA Repair Enzyme HR6A Is a Maternal Factor Essential for Early Embryonic Development in Mice [PDF]

open access: green, 2004
Henk P. Roest   +8 more
openalex   +1 more source

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