Results 271 to 280 of about 63,885 (332)

Regulatory role of ATF2 in trophoblast ferroptosis via the PI3K/Akt/Nrf2 pathway in gestational diabetes mellitus

open access: yesJournal of Diabetes Investigation, EarlyView.
ATF2 is highly expressed in GDM placental tissues and promotes ferroptosis in trophoblast cells by inhibiting the PI3K/Akt/Nrf2 pathway, thereby affecting trophoblast function and GDM progression. ABSTRACT Aims/Introduction To investigate the expression of ATF2 in GDM patients and its impact on trophoblast viability and ferroptosis, as well as to ...
Dandan Xia   +3 more
wiley   +1 more source

The Evolution of Locally Adaptive Chromosome Inversions in Mimulus guttatus

open access: yesMolecular Ecology, EarlyView.
ABSTRACT Chromosomal inversion polymorphisms are ubiquitous across the diversity of diploid organisms and play a significant role in the evolution of adaptations in those species. Inversions are thought to operate as supergenes by trapping adaptive alleles at multiple linked loci through the suppression of recombination. While there is now considerable
Leslie M. Kollar   +4 more
wiley   +1 more source

Molecular Basis of Lys-63-linked Polyubiquitination Inhibition by the Interaction between Human Deubiquitinating Enzyme OTUB1 and Ubiquitin-conjugating Enzyme UBC13

open access: green, 2012
Yusuke Sato   +6 more
openalex   +1 more source

UV RESISTANCE LOCUS 8 signalling enhances photosynthetic resilience to herbicide‐induced damage in Arabidopsis thaliana

open access: yesNew Phytologist, EarlyView.
Summary Perception of low irradiance ultraviolet B (UV‐B) light (280–315 nm) by the UV RESISTANCE LOCUS 8 (UVR8) photoreceptor initiates signalling pathways that enhance plant defences to UV‐B damage, mitigating the effects of higher photon irradiances.
Christopher L. Groves, Keara A. Franklin
wiley   +1 more source

The rhizobial type III effectors ErnA and Sup3 hijack the SUMOylation pathway to trigger nodule formation in Aeschynomene species

open access: yesNew Phytologist, EarlyView.
Summary Rhizobial type III effectors (T3Es) play a crucial role in the symbiotic relationship between rhizobia and legumes by manipulating host cellular processes to promote nodule formation. Previously, we identified two T3Es, ErnA and Sup3, that trigger nodulation in Aeschynomene spp. in the absence of Nod factors.
Fazal Haq   +7 more
wiley   +1 more source

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

open access: yesMolecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin   +6 more
wiley   +1 more source

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