Results 291 to 300 of about 39,918 (341)

Cas9 beyond CRISPR – SUMOylation, effector‐like potential and pathogenic adaptation

The FEBS Journal, EarlyView.
This Viewpoint explores the possibility that Cas9, beyond its canonical role in CRISPR immunity, may act as a host‐modulating effector during infection by Cas9‐encoding bacteria. Such a nucleomodulin‐like function could be influenced by eukaryotic post‐translational modifications, particularly SUMOylation, with potential implications for host–pathogen ...
Umut Sahin
wiley   +1 more source

Decoding neddylation in malignancies: molecular mechanisms, biological functions, therapeutic resistance, and clinical potential. [PDF]

Cell Death Dis
Deng N, Sun Q, Yu X, Li T, Sun J, Jia S, Ma S, Liu W, Zhou H.   +8 more
europepmc   +1 more source

Identification of the first peptide inhibitor of UBE2C enzymatic activity: insights from metadynamics-guided folding and binding studies. [PDF]

J Enzyme Inhib Med Chem
Pirone L, Fiorillo B, Del Gatto A, Russo R, Guarracino A, Cassiano C, Zaccaro L, Moraca F, Pedone E, Catalanotti B.   +9 more
europepmc   +1 more source

Identification and characterization of a ubiquitin E3 RING ligase of the Chlamydia-like bacterium Simkania negevensis. [PDF]

PLoS Pathog
Hörner EM, Lachmayer V, Hermanns T, Moldovan A, Hofmann K, Kozjak-Pavlovic V.   +5 more
europepmc   +1 more source

Cryo-EM structure of the human COP1-DET1 ubiquitin ligase complex. [PDF]

Nat Commun
Wang S, Teng F, Stjepanovic G, Rao F, Su MY.   +4 more
europepmc   +1 more source

Abstract 1423 Investigate a downstream complex by mutating the ubiquitin conjugating enzyme UbcH5b

Maleesha Marakkala Manage
openalex   +2 more sources

Structural basis for substrate recruitment and catalytic ubiquitin transfer by the E2/E3 hybrid enzyme UBE2O. [PDF]

J Biol Chem
Kordic D, Williams TL, Deszcz L, Ehrmann JF, Arnese R, Schleiffer A, Clausen T, Meinhart A.   +7 more
europepmc   +1 more source

Identification and validation of ubiquitination-associated genes of senile osteoporosis based on bioinformatics analysis. [PDF]

Front Immunol
Cheng X, Liu J, Guan Y, Jing B, Zhao J, Cao Y.   +5 more
europepmc   +1 more source

Erythrocyte Spectrin Is An E2 Ubiquitin Conjugating Enzyme.

Cellular & molecular biology letters
Steven R., Goodman, David G, Kakhniashvili, José, Sangerman, Tanuja, Chaudhary, Warren E, Zimmer, F Aladar, Bencsath, Ian, Jardine   +6 more
openaire   +1 more source

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Ubiquitin-conjugating enzyme genes in Oesophagostomum dentatum

Parasitology Research, 2006
Full-length genes representing different isoforms of the ubiquitin-conjugating enzyme UBC-2 were isolated from Oesophagostomum dentatum, cloned and sequenced. The alignment of their sequences (designated Od-ubc-2.1 to Od-ubc-2.3) revealed nucleotide variation at three positions within the predicted open reading frame of 444 bp.
Pauline A, Cottee, Youssef G, Abs EL-Osta, Alasdair J, Nisbet, Robin B, Gasser   +3 more
openaire   +2 more sources