Results 301 to 310 of about 39,918 (341)

Ubiquitin-conjugating enzyme E2C: A potential cancer biomarker

The International Journal of Biochemistry & Cell Biology, 2014
The ubiquitin-conjugating enzymes 2C (UBE2C) is an integral component of the ubiquitin proteasome system. UBE2C consists of a conserved core domain containing the catalytic Cys residue and an N-terminal extension. The core domain is required for ubiquitin adduct formation by interacting with the ubiquitin-fold domain in the E1 enzyme, and contributes ...
Xie, Chanlu (S31301), Powell, Chris (S31711), Yao, Mu, Wu, Jianmin, Dong, Qihan (R16780)   +4 more
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Erythrocyte Spectrin Is an E2 Ubiquitin Conjugating Enzyme

Biochemistry, 2001
The involvement of red blood cell spectrin in the ubiquitination process was studied. Spectrin was found to form two ubiquitin-associated derivatives, a DTT-sensitive ubiquitin adduct and a DTT-insensitive conjugate, characteristic intermediate and final products of the ubiquitination reaction cascade.
D G, Kakhniashvili, T, Chaudhary, W E, Zimmer, F A, Bencsath, I, Jardine, S R, Goodman   +5 more
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Conformational Flexibility of a Ubiquitin Conjugation Enzyme (E2)

Biochemistry, 1999
Ubiquitination plays important roles in a variety of biological processes, such as DNA repair, cell cycle regulation, and p53-dependent processes. Despite intensive studies in ubiquitination, the mechanism of substrate recognition is still not well understood.
Q, Liu, Y C, Yuan, B, Shen, D J, Chen, Y, Chen   +4 more
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Ubiquitin-conjugating enzymes: novel regulators of eukaryotic cells

Trends in Biochemical Sciences, 1990
Covalent attachment of ubiquitin to cellular proteins is essential for cell viability and is catalysed by a set of distinct ubiquitin-conjugating enzymes. Individual members of this novel enzyme family mediate strikingly diverse functions, including DNA repair, cell cycle control, selective protein degradation and essential functions of the stress ...
Jentsch, S., Seufert, W., Sommer, T., Reins, H.   +3 more
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Characterization of the mouse ubiquitin-conjugating enzyme gene UbcM4

Mammalian Genome, 1999
The ubiquitination pathway targets not only normal (short-lived) intracellular eukaryotic proteins for degradation when appropriate, but also serves to eliminate mutant/misfolded proteins from the cell. An understanding of the molecular basis of the interaction between the ubiquitin-conjugating enzymes (E2s), ubiquitin protein ligases (E3s), and target
T P, Moynihan, U, Nuber, H C, Ardley, S A, Rose, A F, Markham, M, Scheffner, P A, Robinson   +6 more
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QRI8, a novel ubiquitin-conjugating enzyme in Saccharomyces cerevisiae

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1992
We have cloned and sequenced the gene encoding a novel ubiquitin-conjugating enzyme in Saccharomyces cerevisiae. Disruption of this gene shows that it is not essential for cell viability.
A, Vassal, A, Boulet, E, Decoster, G, Faye   +3 more
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Characterization of a human ubiquitin-conjugating enzyme gene UBE2L3

Mammalian Genome, 1996
Ubiquitin-conjugating enzymes (E2s) are essential components of the post-translational protein ubiquitination pathway, mediating the transfer of activated ubiquitin to substrate proteins. We have identified a human gene, UBE2L3, localized on Chromosome (Chr) 22q11.
T P, Moynihan, H C, Ardley, J P, Leek, J, Thompson, N S, Brindle, A F, Markham, P A, Robinson   +6 more
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An Altered-specificity Ubiquitin-conjugating Enzyme/Ubiquitin–Protein Ligase Pair

Journal of Molecular Biology, 2004
The human CCR4-NOT complex is a global regulator of RNA polymerase II transcription. Recently, we showed that the RING domain CNOT4 subunit contains intrinsic ubiquitin-protein ligase (E3) activity. Here we show that binding of the CNOT4 RING finger to the ubiquitin-conjugating enzyme (E2) UbcH5B is highly selective.
Winkler, GS, Albert, TK, Dominguez, C, Legtenberg, YI, Boelens, R, Timmers, HT   +5 more
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Location of ubiquitin conjugates and ubiquitin-conjugating enzymes in rabbit brain.

1991
The work reports the location of ubiquitin conjugates and ubiquitin-conjugating enzymes in homogenates of rabbit brain.
MAGNANI, MAURO, SERAFINI, GIORDANO, ANTONELLI, ANTONELLA, CRINELLI, RITA, Manuela Malatesta, Giancarlo Gazzanelli   +5 more
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BRUCE—a giant death-defying ubiquitin-conjugating enzyme

Trends in Cell Biology, 1998
Abstract HAUSER, H-P., BARDROFF, M., PYROWOLAKIS, G. and JENTSCH, S. (1998) A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors J. Cell Biol.
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