Results 121 to 130 of about 118,443 (293)

Proteasome dysfunction in aged human α-synuclein transgenic mice

Neurobiology of Disease, 2006
A deficit in proteasome function in Parkinson's disease has been speculated. We characterized the ubiquitin–proteasome system in three regions of brain from transgenic and nontransgenic littermates.
Li Chen, Mona J. Thiruchelvam, Kiran Madura, Eric K. Richfield   +3 more
doaj   +1 more source

The ubiquitin proteasome system and myocardial ischemia

American Journal of Physiology-Heart and Circulatory Physiology, 2013
The ubiquitin proteasome system (UPS) has been the subject of intensive research over the past 20 years to define its role in normal physiology and in pathophysiology. Many of these studies have focused in on the cardiovascular system and have determined that the UPS becomes dysfunctional in several pathologies such as familial and idiopathic ...
Justine, Calise, Saul R, Powell
openaire   +3 more sources

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

Advanced Science, EarlyView.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang, Peipei Song, Xueji Wu, Lei Wang, Wei Xie, Pinning Feng, Chao Cheng, Jianping Guo   +7 more
wiley   +1 more source

The ubiquitin-proteasome system during proteotoxic stress [PDF]

, 2006
The dual function of the ubiquitin-proteasome system in protein quality control and as a master regulator of vital cellular processes places the system in a delicate position.
Victoria Menéndez Benito (19488937)
core  

Regulation of the 26S Proteasome: From Homeostasis to Stress and Disease

Cells
The ubiquitin–proteasome system (UPS) has traditionally been described as a tightly regulated degradative network driven mainly by the specificity of its ubiquitin-conjugating enzymatic components.
Victoria Cohen-Kaplan, Aaron Ciechanover, Yelena Kravtsova-Ivantsiv   +2 more
doaj   +1 more source

NLSS3 Impairs SHM1 Autophagic Degradation to Regulate Leaf Morphology and Salt Tolerance in Rice

Advanced Science, EarlyView.
In rice, NLSS3 binds and shields SHM1 from autophagic degradation to maintain serine homeostasis. The A132P mutation in nlss3 disrupts this, triggering SHM1 loss, metabolic dysfunction, K+ imbalance, and impaired ROS scavenging, which collectively drive narrow leaves and salt sensitivity.
Xiong Liu, Yulu Yang, Zhiqi Hao, Jing Xu, Huibo Zhao, Qiang Zhang, Deyong Ren, Xia Li, Guojun Dong, Lan Shen, Li Zhu, Jiang Hu, Zhenyu Gao, Qing Li, Qian Qian, Guangheng Zhang   +15 more
wiley   +1 more source

Functional study of ubiquitin C-terminal hydrolase-L1 gene promoter haplotypes [PDF]

, 2007
The Ubiquitin Conjugating System (UCS) describes a system in which the 96-amino acid residue Ubiquitin can be selectively covalently linked to intracellular proteins.
Sanassy, Shane
core  

The Deubiquitinase Inhibitor b-AP15 and Its Effect on Phenotype and Function of Monocyte-Derived Dendritic Cells

Neoplasia: An International Journal for Oncology Research, 2019
The ubiquitin-proteasome system is elementary for cellular protein degradation and gained rising attention as a new target for cancer therapy due to promising clinical trials with bortezomib, the first-in class proteasome inhibitor meanwhile approved for
Moritz Schmidt, Vanessa Altdörfer, Sarah Schnitte, Alexander Rolf Fuchs, Korbinian Nepomuk Kropp, Stefanie Maurer, Martin Rudolf Müller, Helmut Rainer Salih, Susanne Malaika Rittig, Frank Grünebach, Daniela Dörfel   +10 more
doaj   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

A Molecular Signature of the Ubiquitin-Proteasome System for Forecasting Prognosis in Thyroid Carcinoma Patients [PDF]

Hong Zeng,1,2,* Xitong Geng,2,* Hao Wan,3,* Xiaoyu Qu,2 Shengwei Tang,2 Ruiyu Zhang,3 Minqin Zhou,2 Zichuan Yu,2 Jingying Pan,3 Hao Zheng,2 Yanting Zhu,2 Shuhan Huang,2 Da Huang1 1Department of Thyroid Surgery, Second Affiliated Hospital of ...
Zhou M, Huang D, Geng X, Zhu Y, Zhang R, Pan J, Huang S, Zheng H, Tang S, Zeng H, Qu X, Wan H, Yu Z   +12 more
core   +1 more source