Results 11 to 20 of about 80,046 (337)
The Role of NEDD4 E3 Ubiquitin-Protein Ligases in Parkinson's Disease. [PDF]
Genes (Basel), 2022 Parkinson’s disease (PD) is a debilitating neurodegenerative disease that causes a great clinical burden. However, its exact molecular pathologies are not fully understood. Whilst there are a number of avenues for research into slowing, halting, or reversing PD, one central idea is to enhance the clearance of the proposed aetiological protein ...
Conway JA, Kinsman G, Kramer ER.
europepmc +3 more sources
NEDD4: The founding member of a family of ubiquitin-protein ligases. [PDF]
Gene, 2015 Ubiquitination plays a crucial role in regulating proteins post-translationally. The focus of this review is on NEDD4, the founding member of the NEDD4 family of ubiquitin ligases that is evolutionarily conserved in eukaryotes. Many potential substrates of NEDD4 have been identified and NEDD4 has been shown to play a critical role in the regulation of ...
Boase NA, Kumar S.
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Ubiquitin-protein ligases [PDF]
Journal of Cell Science, 2004 Post-translational covalent tagging of proteins with the 76-residue protein ubiquitin (Ub) serves many functions. Polyubiquitylated proteins are directed to the large multi-component, multi-catalytic protease the 26S proteasome.
Philip A. Robinson, H. C. Ardley
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The Role of Ubiquitin-Protein Ligases in Neurodegenerative Disease [PDF]
Neurodegenerative Diseases, 2004 Alzheimer’s disease and Parkinson’s disease are the most common neurodegenerative conditions associated with the ageing process. The pathology of these and other neurodegenerative disorders, including polyglutamine diseases, is characterised by the presence of inclusion bodies in brain tissue of affected patients.
Helen C. Ardley, Philip A. Robinson
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UBE3A (ubiquitin protein ligase E3A) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on UBE3A (ubiquitin protein ligase E3A), with data on DNA, on the protein encoded, and where the gene is implicated.
Matentzoglu, K, Scheffner, M
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How to Inactivate Human Ubiquitin E3 Ligases by Mutation
Frontiers in Cell and Developmental Biology, 2020 E3 ubiquitin ligases are the ultimate enzymes involved in the transfer of ubiquitin to substrate proteins, a process that determines the fate of the modified protein.
Cristina Garcia-Barcena +4 more
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TRIM56 coiled-coil domain structure provides insights into its E3 ligase functions
Computational and Structural Biotechnology Journal, 2023 Protein ubiquitination is a post-translation modification mediated by E3 ubiquitin ligases. The RING domain E3 ligases are the largest family of E3 ubiquitin ligases, they act as a scaffold, bringing the E2-ubiquitin complex and its substrate together to
Xiaohua Lou +7 more
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Functional Domains of the Rsp5 Ubiquitin-Protein Ligase [PDF]
Molecular and Cellular Biology, 1999 RSP5, an essential gene of Saccharomyces cerevisiae, encodes a hect domain E3 ubiquitin-protein ligase. Hect E3 proteins have been proposed to consist of two broad functional domains: a conserved catalytic carboxyl-terminal domain of approximately 350 amino acids (the hect domain) and a large, nonconserved amino-terminal domain containing determinants ...
Joyce C. Yang +2 more
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The Biological Function and Roles in Phytohormone Signaling of the F-Box Protein in Plants
Agronomy, 2021 The ubiquitin–proteasome pathway (UPP) is an important protein degradation pathway that can participate in the regulation of the physiological process of organisms by specifically removing abnormal peptides and degrading cell regulators.
Keheng Xu +5 more
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E3 Ubiquitin Ligases as Cancer Targets and Biomarkers
Neoplasia: An International Journal for Oncology Research, 2006 E3 ubiquitin ligases are a large family of proteins that are engaged in the regulation of the turnover and activity of many target proteins. Together with ubiquitinactivating enzyme El and ubiquitin-conjugating enzyme E2, E3 ubiquitin ligases catalyze ...
Yi Sun
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