The roles of E3 ubiquitin ligases in cancer progression and targeted therapy
Clinical and Translational Medicine, 2023 Ubiquitination is one of the most important post‐translational modifications which plays a significant role in conserving the homeostasis of cellular proteins.
Chibuzo Sampson +6 more
semanticscholar +2 more sources
U Box Proteins as a New Family of Ubiquitin-Protein Ligases* [PDF]
Journal of Biological Chemistry, 2001 The U box is a domain of approximately 70 amino acids that is present in proteins from yeast to humans. The prototype U box protein, yeast Ufd2, was identified as a ubiquitin chain assembly factor that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin-protein ligase (E3) to catalyze ubiquitin chain
S. Hatakeyama +4 more
semanticscholar +4 more sources
SCF ubiquitin protein ligases and phosphorylation-dependent proteolysis.
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1999 Many key activators and inhibitors of cell division are targeted for degradation by a recently described family of E3 ubiquitin protein ligases termed Skp1-Cdc53-F-box protein (SCF) complexes.
A. Willems +5 more
semanticscholar +5 more sources
Regulation of Neuronal Voltage-gated Sodium Channels by the Ubiquitin-Protein Ligases Nedd4 and Nedd4-2 [PDF]
Journal of Biological Chemistry, 2004 Nedd4 and Nedd4-2 are ubiquitin-protein ligases known to regulate a number of membrane proteins including receptors and ion transporters. Regulation of the epithelial Na+ channel by Nedd4 and Nedd4-2 is mediated via interactions between the PY motifs of ...
Andrew B. Fotia +5 more
openalex +2 more sources
Proteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma virus and are required for gag budding from cells [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2001 Alexandra Kikonyogo +6 more
openalex +2 more sources
Expression of Pirh2, a Newly Identified Ubiquitin Protein Ligase, in Lung Cancer [PDF]
JNCI Journal of the National Cancer Institute, 2004 Maintenance of p53 function is important for normal cell growth and development, and loss of p53 function contributes directly to malignant tumor development. The recently discovered Pirh2 protein is an ubiquitin-protein ligase that negatively regulates p53 through activity by targeting it for degradation.
Wenrui Duan +6 more
openalex +4 more sources
Interaction of U‐box‐type ubiquitin‐protein ligases (E3s) with molecular chaperones [PDF]
Genes to Cells, 2004 Shigetsugu Hatakeyama +3 more
openalex +2 more sources
The role of E3 ubiquitin ligases and deubiquitinases in bladder cancer development and immunotherapy
Frontiers in Immunology, 2023 Bladder cancer is one of the common malignant urothelial tumors. Post-translational modification (PTMs), including ubiquitination, acetylation, methylation, and phosphorylation, have been revealed to participate in bladder cancer initiation and ...
Xuemei Wang +4 more
doaj +1 more source
Thoracic Cancer, 2022 Background Lung adenocarcinoma (LUAD) is the most common subtype of non‐small cell lung cancer and has a poor prognosis. RBR E3 ubiquitin ligases are a special class of E3 ubiquitin ligases which contain three zinc‐bing domains that catalyze ubiquitin to
Hao Ding +12 more
doaj +1 more source
Frontiers in Oncology, 2021 Female breast cancer has become the most commonly occurring cancer worldwide. Although it has a good prognosis under early diagnosis and appropriate treatment, breast cancer metastasis drastically causes mortality.
Yingshuang Wang +8 more
doaj +1 more source