The HECT ubiquitin‐protein ligase (UPL) family in Arabidopsis: UPL3 has a specific role in trichome development [PDF]
, 2003 Brian P. Downes +3 more
openalex +1 more source
Advanced Science, EarlyView.An integrative analysis combining in vitro genome‐wide immune screens, in vivo ICB screens, and clinical data mining identifies METTL5 as a key tumor‐intrinsic immune factor. Mechanistic studies further reveal the importance of the METTL5‐ATF4‐SLC7A11/SLC3A2‐ferroptosis axis in modulating antitumor immune responses. These findings highlight METTL5 as a
Jiakai Hou +30 more
wiley +1 more source
ARC1 Is an E3 Ubiquitin Ligase and Promotes the Ubiquitination of Proteins during the Rejection of Self-Incompatible Brassica Pollen [PDF]
, 2003 Sophia L. Stone +3 more
openalex +1 more source
Advanced Science, EarlyView.OsNRT1.1B forms a membrane complex with OsCNGC14/16 that mediates nitrate‐triggered calcium influx. This calcium signal phosphorylates OsNLP3 at Ser193, accelerating its nuclear translocation and activating nitrogen‐responsive genes. The calcium‐dependent pathway complements the established ubiquitination‐mediated pathway, dynamically regulating ...
Xiaohan Wang +9 more
wiley +1 more source
Interpretable PROTAC Degradation Prediction With Structure‐Informed Deep Ternary Attention Framework
Advanced Science, EarlyView.PROTAC‐STAN, a structure‐informed deep learning framework is presented for interpretable PROTAC degradation prediction. By modeling molecular hierarchies and protein structures, and simulating ternary interactions via a novel attention network, PROTAC‐STAN achieves significant performance gains over baselines.
Zhenglu Chen +11 more
wiley +1 more source
The BAL-binding Protein BBAP and Related Deltex Family Members Exhibit Ubiquitin-Protein Isopeptide Ligase Activity [PDF]
, 2003 Kunihiko Takeyama +7 more
openalex +1 more source
Overexpression of the Tumor Autocrine Motility Factor Receptor Gp78, a Ubiquitin Protein Ligase, Results in Increased Ubiquitinylation and Decreased Secretion of Apolipoprotein B100 in HepG2 Cells [PDF]
, 2003 Jun-shan Liang +6 more
openalex +1 more source
Role of HECT ubiquitin protein ligases in Arabidopsis thaliana [PDF]
Journal of Plant Science and Phytopathology, 2018 Wei Lan, Ying Miao, Weibo Ma
openaire +1 more source
SP3 and DEP1 Orchestrate Panicle Architecture by Jointly Regulating APO2 Expression in Rice
Advanced Science, EarlyView.The transcription factor SP3 enhances inflorescence meristem activity and interacts with the cysteine‐rich domain of DEP1. This interaction alters DEP1's subcellular localization between the plasma membrane and nucleus, and suppresses SP3‐mediated transcriptional activation of APO2.
Yuexin Liu +11 more
wiley +1 more source
The HECT ubiquitin-protein ligases UPL1 and UPL2 are involved in degradation of Arabidopsis thaliana ACC synthase 7. [PDF]
Physiol PlantMarczak M +5 more
europepmc +1 more source