Results 221 to 230 of about 81,275 (289)

Role of ubiquitin‑proteasome system in preeclampsia (Review). [PDF]

Mol Med Rep
Pei CZ, Song XX, Xu H, Baek KH.
europepmc   +1 more source

Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1 [PDF]

, 2008
Frederik Eisele, Dieter H. Wolf
openalex   +1 more source

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li, Xiaochen Zhang, Jiangwei Xia, Shuang Liu, Yushan Du, Sihan Li, Shukui Zhang, Yong Zhang, Fen Ji, Jianwei Jiao, Jingjing Zhang   +10 more
wiley   +1 more source

Proteolysis-targeting chimeras in cancer therapy: Targeted protein degradation for next-generation treatment. [PDF]

Cancer
Anaya YA, Barragan M, Bracho RP, Shaham SH, Bandyopadhyay D, George E, Nguyen D, Tripathi MK.   +7 more
europepmc   +1 more source

Targeting the Dynamics Between TAMs and CAR‐T Cells in Solid Tumor Therapies

Advanced Science, EarlyView.
This review highlights the critical role of tumor‐associated macrophages (TAMs) in affecting CAR‐T cell therapy effectiveness in solid tumors. TAMs contribute to immune suppression through cytokine secretion, immune checkpoint activation, and metabolic reprogramming, leading to CAR‐T cell exhaustion and reduced efficacy. The article explores strategies
Xiang Zhang, Hao Zheng, Zi‐Chang Liu, Ling‐Jie Luo, Xiao Dong, Xin‐Gang Cui, Yan‐Wei Wu, Liang Chen   +7 more
wiley   +1 more source

<i>MMRN1</i> as a Potential Oncogene in Gastric Cancer: Functional Evidence from In Vitro Studies and Computational Prediction of <i>NEDD4L</i>-Mediated Ubiquitination. [PDF]

Curr Issues Mol Biol
Cai Z, Zhang M, Zeng Q, Deng Y, Li D.
europepmc   +1 more source

The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells [PDF]

, 2019
Maxime Jacoupy, Emeline Hamon-Keromen, Alban Ordureau, Zoi Erpapazoglou, Francis Cogé, Jean‐Christophe Corvol, Olivier Nosjean, Clotilde Mannoury la Cour, Mark J. Millan, Jean A. Boutin, J. Wade Harper, Alexis Brice, Denis Guédin, Cécile Gautier, Olga Corti   +14 more
openalex   +1 more source

HUWE1 in Skeletal Muscle Prevents Muscle Fatigue via Maintaining Iron and Calcium Homeostasis

Advanced Science, EarlyView.
This study investigates the impact of iron homeostasis on exercise. Loss of the HECT domain‐containing ubiquitin ligase E3 (HUWE1) in skeletal muscle restrains the exercise performance in mice with downregulated ferroportin expression leading to iron overload, which is ameliorated by dietary iron restriction.
Huike Jiao, Yuting Du, Danxia Zhou, Meng Bai, Xu Gao, Zhenyue Hao, Nan‐Jie Xu, Jiaqiang Liu, Ying Huang, Zhenji Gan, Jing Zhang   +10 more
wiley   +1 more source

A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-mediated apoptotic cell death in its catalytic activity-independent manner [PDF]

, 2008
Y Li, Toshinori Ozaki, Hironobu Kikuchi, Hideki Yamamoto, Miki Ohira, Akira Nakagawara   +5 more
openalex   +1 more source

Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion

Advanced Science, EarlyView.
FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao, Siyuan Chai, Mingyang Li, Xiaoming Chen, Jiating Hu, Bingyi Lin, Liming Wu, Wen Yi, Qiang Zhu   +8 more
wiley   +1 more source