Results 221 to 230 of about 129,362 (255)

E3 ubiquitin-protein ligases in rat kidney collecting duct: response to vasopressin stimulation and withdrawal.

AJP - Renal Physiology, 2011
The E3 ubiquitin (Ub)-protein ligases (E3s) play a role as regulators of protein trafficking and degradation. We aimed to integrate the profile of E3s in rat kidney and examine the changes in protein abundance of the selected E3s in response to 1-deamino-
Yu-Jung Lee, Jeongeun Lee, Hyo-Jung Choi, Jung-Suk Lim, Hyun Jun Jung, M. Baek, J. Frøkiær, S. Nielsen, T. Kwon   +8 more
semanticscholar   +1 more source

Identification of the ubiquitin–protein ligase that recognizes oxidized IRP2

Nature Cell Biology, 2003
The ubiquitin system is involved in several basic cellular functions. Ubiquitination is carried out by a cascade of three reactions catalysed by the E1, E2 and E3 enzymes. Among these, the E3 ubiquitin-protein ligases have a pivotal role in determining the specificity of the system by recognizing the target substrates through defined targeting motifs ...
Nagahiro Minato, Tracey A. Rouault, Haruto Ishikawa, Haruto Ishikawa, Fuminori Tokunaga, Masato Kanie, Kazuhiro Iwai, Kazuhiro Iwai, Isao Morishima, Koichiro Ishimori, Koji Yamanaka, Yuzuru Megumi   +11 more
openaire   +3 more sources

Role of Ubiquitin Protein Ligases in the Pathogenesis of Polyglutamine Diseases

Neurochemical Research, 2007
The accumulation of intracellular protein deposits as inclusion bodies is the common pathological hallmark of most age related neurodegenerative disorders including polyglutamine diseases. Appearances of aggregates of the misfolded mutant disease proteins suggest that the cells are unable to efficiently degrade them, and failure of clearance leads to ...
Priyanka Dikshit, Nihar Ranjan Jana
openaire   +3 more sources

Progress in regulation of activity and stability of ubiquitin protein ligase MDM2

Hereditas (Beijing), 2009
The ubiquitin protein ligase (E3) MDM2 (Murine double minute 2) possesses oncogenic activities. Overexpression of this protein enhances degradation and inactivation of the tumor suppressor p53. At least 7% of all human tumors exhibit inappropriate amplification of mdm2, whereas p53 gene remains in its wild-type configuration.
Jing NIE, Chun-Yan TIAN, Ling-Qiang ZHANG   +2 more
openaire   +3 more sources

Ring finger ubiquitin protein ligases and their implication to the pathogenesis of human diseases.

Current pharmaceutical design, 2009
The ubiquitin proteasome system (UPS) plays a fundamental role in maintaining the correct balance of protein levels inside all living cells. Degradation of proteins by this pathway is essential for most cellular processes including cell signalling, DNA ...
H. Ardley
semanticscholar   +1 more source

An Altered-specificity Ubiquitin-conjugating Enzyme/Ubiquitin–Protein Ligase Pair

Journal of Molecular Biology, 2004
The human CCR4-NOT complex is a global regulator of RNA polymerase II transcription. Recently, we showed that the RING domain CNOT4 subunit contains intrinsic ubiquitin-protein ligase (E3) activity. Here we show that binding of the CNOT4 RING finger to the ubiquitin-conjugating enzyme (E2) UbcH5B is highly selective.
Winkler, GS, Albert, TK, Dominguez, C, Legtenberg, YI, Boelens, R, Timmers, HT   +5 more
openaire   +5 more sources

RING domain E3 ubiquitin ligases.

Annual Review of Biochemistry, 2009
E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate.
R. Deshaies, C. Joazeiro
semanticscholar   +1 more source

Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors

Nature Immunology, 2004
Activation of Toll-like receptors (TLRs) results in a proinflammatory response needed to combat infection. Thus, limiting TLR signaling is essential for preventing a protective response from causing injury to the host. Here we describe how a RING finger protein, Triad3A, acts as an E3 ubiquitin-protein ligase and enhances ubiquitination and proteolytic
Richard J. Ulevitch, Tsung-Hsien Chuang
openaire   +3 more sources

Challenges in the use of sortase and other peptide ligases for site-specific protein modification

Chemical Society Reviews, 2022
Holly E Morgan, W Bruce Turnbull, Michael E Webb   +2 more
exaly  

Certain Pairs of Ubiquitin-conjugating Enzymes (E2s) and Ubiquitin-Protein Ligases (E3s) Synthesize Nondegradable Forked Ubiquitin Chains Containing All Possible Isopeptide Linkages*

Journal of Biological Chemistry, 2007
Isopeptide Linkages, Hyoung-Tae Kim, Kwang Pyo Kim, F. Lledías, A. Kisselev, K. Scaglione, D. Skowyra, S. Gygi, A. Goldberg   +8 more
semanticscholar   +1 more source