Results 61 to 70 of about 3,429,300 (308)

Small Molecule Modulators of RING-Type E3 Ligases: MDM and Cullin Families as Targets

Frontiers in Pharmacology, 2018
Ubiquitin–proteasome system (UPS) is a primary signaling pathway for regulation of intracellular protein levels. E3 ubiquitin ligases, substrate-specific members of the UPS, represent highly attractive protein targets for drug discovery.
Emil Bulatov, Almaz Zagidullin, Aygul Valiullina, Regina Sayarova, Albert Rizvanov   +4 more
doaj   +1 more source

Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1 [PDF]

, 2012
Loss of the tumor suppressor Pdcd4 was reported for various tumor entities and proposed as a prognostic marker in tumorigenesis. We previously characterized decreased Pdcd4 protein stability in response to mitogenic stimuli, which resulted from p70S6K1 ...
Bernhard Brüne, Milke, Larissa, Kathrin Schulz, Larissa Milke, Heidi R Bokesch, Schulz, Kathrin, Colburn, Nancy H., Blees, Johanna, Schmid, Tobias, Curtis J. Henrich (131182), Tobias Schmid, Kathrin Schulz (131170), Magdalena M. Bajer (131176), Heidi R. Bokesch (131163), Bajer, Magdalena M., Daniela Rübsamen (131166), Johanna S Blees, Henrich, Curtis J., Nancy H. Colburn (131186), James B McMahon, Magdalena M Bajer, James B. McMahon (7677), McMahon, James B., Daniela Rübsamen, Kirk R. Gustafson (131179), Tobias Schmid (131190), Nancy H Colburn, Brüne, Bernhard, Kirk R Gustafson, Rübsamen, Daniela, Bernhard Brüne (131193), Curtis J Henrich, Bokesch, Heidi R., Gustafson, Kirk R., Larissa Milke (131173), Johanna S. Blees (131161)   +35 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The fanconi anemia DNA repair pathway is regulated by an interaction between ubiquitin and the E2-like fold domain of FANCL [PDF]

, 2015
The Fanconi Anemia (FA) DNA repair pathway is essential for the recognition and repair of DNA interstrand crosslinks (ICL). Inefficient repair of these ICL can lead to leukemia and bone marrow failure.
Howard, Mark J., Sidhu, Ateesh, Chaugule, Viduth K., Alpi, Arno F., Miles, Jennifer A., Carroll, Eilis, Frost, Mark G., Rowe, Michelle L., Walden, Helen   +8 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Targeting E3 ubiquitin ligases: a new frontier in idiopathic pulmonary fibrosis treatment

Frontiers in Immunology
Ubiquitination is a modification prevalent in eukaryotic cells. Disruptions in ubiquitination processes can have detrimental effects, potentially leading to diseases that endanger life.
Kun Zhang, Hui Yuan, Lin Shi
doaj   +1 more source

The Role of the Cullin-5 E3 Ubiquitin Ligase in the Regulation of Insulin Receptor Substrate-1

Biochemistry Research International, 2012
Background. SOCS proteins are known to negatively regulate insulin signaling by inhibiting insulin receptor substrate-1 (IRS1). IRS1 has been reported to be a substrate for ubiquitin-dependent proteasomal degradation.
Christine Zhiwen Hu, Jaswinder K. Sethi, Thilo Hagen   +2 more
doaj   +1 more source

Interplay between bacterial deubiquitinase and ubiquitin E3 ligase regulates ubiquitin dynamics on Legionella phagosomes

eLife, 2020
Legionella pneumophila extensively modulates the host ubiquitin network to create the Legionella-containing vacuole (LCV) for its replication. Many of its virulence factors function as ubiquitin ligases or deubiquitinases (DUBs).
Shuxin Liu, Jiwei Luo, Xiangkai Zhen, Jiazhang Qiu, Songying Ouyang, Zhao-Qing Luo   +5 more
doaj   +1 more source

The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice

BMC Biology, 2022
Background Ubiquitination is a post-translational modification required for a number of physiological functions regulating protein homeostasis, such as protein degradation.
Kaori Nozawa, Yoshitaka Fujihara, Darius J. Devlin, Ricardo E. Deras, Katarzyna Kent, Irina V. Larina, Kohei Umezu, Zhifeng Yu, Courtney M. Sutton, Qiuji Ye, Laura K. Dean, Chihiro Emori, Masahito Ikawa, Thomas X. Garcia, Martin M. Matzuk   +14 more
doaj   +1 more source

The San1 Ubiquitin Ligase Avidly Recognizes Misfolded Proteins through Multiple Substrate Binding Sites

Biomolecules, 2021
Cellular homeostasis depends on robust protein quality control (PQC) pathways that discern misfolded proteins from functional ones in the cell. One major branch of PQC involves the controlled degradation of misfolded proteins by the ubiquitin-proteasome ...
Rebeca Ibarra, Heather R. Borror, Bryce Hart, Richard G. Gardner, Gary Kleiger   +4 more
doaj   +1 more source