Results 181 to 190 of about 596,162 (342)
Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity
Advanced Science, EarlyView.Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu +8 more
wiley +1 more source
β‐catenin is a target for the ubiquitin–proteasome pathway
, 1997 H. Aberle +4 more
semanticscholar +1 more source
Advanced Science, EarlyView.Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo +7 more
wiley +1 more source
Ubiquitin E3 ligase KLHL6 brings exhausted T-cells back into action. [PDF]
Immun InflammChen Z, Bullock AN, Kessler BM.
europepmc +1 more source
Recognition and processing of ubiquitin-protein conjugates by the proteasome.
Annual Review of Biochemistry, 2009 D. Finley
semanticscholar +1 more source
Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions
Advanced Science, EarlyView.This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang +4 more
wiley +1 more source
Identification of Ubiquitin Genes and Their Expression Patterns in <i>Pinus massoniana</i> Under Infection Stress from the Pinewood Nematode. [PDF]
Plants (Basel)Chen Q +7 more
europepmc +1 more source
Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids
Advanced Science, EarlyView.Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan +19 more
wiley +1 more source
Advances in protein ubiquitination modification and immune evasion of breast cancer. [PDF]
Front Cell Dev BiolWu Y, Jin J, Cheng X, Fu Z, Xie H.
europepmc +1 more source