Results 221 to 230 of about 596,162 (342)

OTUB1 stabilizes PRRSV matrix protein through a non-canonical deubiquitination mechanism to promote viral replication. [PDF]

J Virol
Liu B, Liang W, Li X, Jiang S, Shi Z, Liu N, Zhu R, Dong X, Zhou H, Zhou B, Cui J.   +10 more
europepmc   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Proteasomal control of transcription factors: mechanisms, regulation and dysregulation. [PDF]

Cell Mol Life Sci
Larsen FB, Kragelund BB, Lindorff-Larsen K, Heidarsson PO, Hartmann-Petersen R.   +4 more
europepmc   +1 more source

Insights into ubiquitin chain architecture using Ub-clipping

Nature, 2019
Kirby N. Swatek, Joanne L. Usher, Anja F. Kueck, C. Gladkova, T. Mevissen, J. Pruneda, T. Skern, D. Komander   +7 more
semanticscholar   +1 more source

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

SHPRH together with the Ube2D family of enzymes directly ubiquitinates PCNA at Lys164 in vitro. [PDF]

PLoS One
Wang X, Hu Y, Wen Y, Shen M, Chen P, Xiang S.   +5 more
europepmc   +1 more source

G4‐Ligand‐Directed PROTACs Unveil DR1 as a Novel Ligand‐Co‐Binding G4‐Protein and Reshape G4‐Dependent Transcription

Advanced Science, EarlyView.
G4‐binding proteins (G4BPs) that specifically co‐bind G4s in the presence of small‐molecule ligands represent a critical but unexplored class of proteins. We introduce G4‐Ligand‐Directed PROTACs (G4L‐TACs), a chemical platform that couples G4 ligands (PDS) to E3 recruiters to selectively degrade these ligand‐co‐binding G4BPs.
Mao‐Lin Li, Shu‐Min Xu, Xin‐Chen Jiang, Le‐Tian Dai, Yu‐Tao Hu, Kai‐Bo Wang, Jia‐Heng Tan, Zhi‐Shu Huang, Shuo‐Bin Chen   +8 more
wiley   +1 more source

Mechanisms and Design Principles of Proteolysis-Targeting Chimeras and Their Emerging Applications. [PDF]

ACS Pharmacol Transl Sci
Knoll N, Neamati N, Üren A.
europepmc   +1 more source

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

Advanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong, Jingyi Lu, Haopeng Li, Jun Zhong, Xiaobei Luo, Yiyi Hu, Xianfei Wang, Pengfei Wang, Yanning Zhang, Zhenjiang Wang, Qiuhua Lai, Zhenyu Chen, Wenting Mi, Wang Tin San‐to, Weize Li, Shuping Tan, Qihong Cheng, Ruijia Li, Yida Nie, Side Liu, Bing Huang, Zelong Han   +21 more
wiley   +1 more source

Amide ¹H and ¹⁵N NMR signal assignments of all naturally-occurring di-ubiquitins. [PDF]

Biomol NMR Assign
Kurbah I, Castañeda CA, Fushman D.
europepmc   +1 more source