Results 361 to 370 of about 574,104 (383)

Ubiquitin in chains

Trends in Biochemical Sciences, 2000
The ubiquitin-proteasome system fulfills an essential function in eukaryotes by controlling the levels of crucial intracellular regulatory proteins. In this system, a specific type of polyubiquitin chain acts as the proximal signal for targeting substrates to 26S proteasomes for degradation.
openaire   +3 more sources

The Ubiquitin System, Autophagy, and Regulated Protein Degradation.

Annual Review of Biochemistry, 2017
This brief disquisition about the early history of studies on regulated protein degradation introduces several detailed reviews about the ubiquitin system and autophagy.
A. Varshavsky
semanticscholar   +1 more source

Ubiquitin and ubiquitin-like proteins as multifunctional signals

Nature Reviews Molecular Cell Biology, 2005
Protein ubiquitylation is a recognized signal for protein degradation. However, it is increasingly realized that ubiquitin conjugation to proteins can be used for many other purposes. Furthermore, there are many ubiquitin-like proteins that control the activities of proteins.
Colin Gordon, R. John Mayer, Rebecca Welchman   +2 more
openaire   +3 more sources

Structure and Evolution of Ubiquitin and Ubiquitin-Related Domains

2012
Since its discovery over three decades ago, it has become abundantly clear that the ubiquitin (Ub) system is a quintessential feature of all aspects of eukaryotic biology. At the heart of the system lies the conjugation and deconjugation of Ub and Ub-like (Ubls) proteins to proteins or lipids drastically altering the biochemistry of the targeted ...
A. Maxwell Burroughs, L. Aravind, Lakshminarayan M. Iyer   +2 more
openaire   +2 more sources

The ubiquitin system

Nature Network Boston, 2000
A. Hershko, A. Ciechanover, A. Varshavsky   +2 more
semanticscholar   +1 more source

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

Nature, 2002
C. Hoege, B. Pfander, George-Lucian Moldovan, George Pyrowolakis, S. Jentsch   +4 more
semanticscholar   +1 more source

Proteome-wide identification of ubiquitin interactions using UbIA-MS

Nature Protocols, 2018
Xiaofei Zhang, A. H. Smits, G. B. van Tilburg, H. Ovaa, W. Huber, M. Vermeulen   +5 more
semanticscholar   +1 more source

Building and decoding ubiquitin chains for mitophagy

Nature reviews. Molecular cell biology, 2018
Wade Harper, A. Ordureau, Jin-Mi Heo
semanticscholar   +1 more source

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

Nature, 2001
chen wang, L. Deng, Mei Hong, G. Akkaraju, J. Inoue, Zhijian J. Chen   +5 more
semanticscholar   +1 more source

Monitoring MHC Ubiquitination by MARCH Ubiquitin Ligases

2019
Ubiquitination is a reversible process that controls the intracellular transport of many transmembrane molecules. Ubiquitination of MHC I, MHC II, and CD1a by different members of the MARCH family of E3 ubiquitin ligases is a key event in the regulation of the potent immunostimulatory properties of activated dendritic cells. We describe here methods to
openaire   +3 more sources