Results 361 to 370 of about 574,104 (383)
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Trends in Biochemical Sciences, 2000
The ubiquitin-proteasome system fulfills an essential function in eukaryotes by controlling the levels of crucial intracellular regulatory proteins. In this system, a specific type of polyubiquitin chain acts as the proximal signal for targeting substrates to 26S proteasomes for degradation.
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The ubiquitin-proteasome system fulfills an essential function in eukaryotes by controlling the levels of crucial intracellular regulatory proteins. In this system, a specific type of polyubiquitin chain acts as the proximal signal for targeting substrates to 26S proteasomes for degradation.
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The Ubiquitin System, Autophagy, and Regulated Protein Degradation.
Annual Review of Biochemistry, 2017This brief disquisition about the early history of studies on regulated protein degradation introduces several detailed reviews about the ubiquitin system and autophagy.
A. Varshavsky
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Ubiquitin and ubiquitin-like proteins as multifunctional signals
Nature Reviews Molecular Cell Biology, 2005Protein ubiquitylation is a recognized signal for protein degradation. However, it is increasingly realized that ubiquitin conjugation to proteins can be used for many other purposes. Furthermore, there are many ubiquitin-like proteins that control the activities of proteins.
Colin Gordon+2 more
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Structure and Evolution of Ubiquitin and Ubiquitin-Related Domains
2012Since its discovery over three decades ago, it has become abundantly clear that the ubiquitin (Ub) system is a quintessential feature of all aspects of eukaryotic biology. At the heart of the system lies the conjugation and deconjugation of Ub and Ub-like (Ubls) proteins to proteins or lipids drastically altering the biochemistry of the targeted ...
A. Maxwell Burroughs+2 more
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RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
Nature, 2002C. Hoege+4 more
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Proteome-wide identification of ubiquitin interactions using UbIA-MS
Nature Protocols, 2018Xiaofei Zhang+5 more
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Building and decoding ubiquitin chains for mitophagy
Nature reviews. Molecular cell biology, 2018Wade Harper, A. Ordureau, Jin-Mi Heo
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TAK1 is a ubiquitin-dependent kinase of MKK and IKK
Nature, 2001chen wang+5 more
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Monitoring MHC Ubiquitination by MARCH Ubiquitin Ligases
2019Ubiquitination is a reversible process that controls the intracellular transport of many transmembrane molecules. Ubiquitination of MHC I, MHC II, and CD1a by different members of the MARCH family of E3 ubiquitin ligases is a key event in the regulation of the potent immunostimulatory properties of activated dendritic cells. We describe here methods to
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