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Identification of E3 Ubiquitin Ligase Substrates Using Biotin Ligase-Based Proximity Labeling Approaches [PDF]

Biomedicines
Ubiquitylation is a post-translational modification originally identified as the first step in protein degradation by the ubiquitin–proteasome system. Ubiquitylation is also known to regulate many cellular processes without degrading the ubiquitylated ...
Koji Matsuhisa, Shinya Sato, Masayuki Kaneko   +2 more
doaj   +2 more sources

Emerging roles of the HECT E3 ubiquitin ligases in gastric cancer

Pathology and Oncology Research, 2023
Gastric cancer (GC) is one of the most pernicious gastrointestinal tumors with extraordinarily high incidence and mortality. Ubiquitination modification of cellular signaling proteins has been shown to play important roles in GC tumorigenesis ...
Aiqin Sun, Aiqin Sun, Xianyan Tian, Yifei Chen, Wannian Yang, Qiong Lin   +5 more
doaj   +1 more source

The San1 Ubiquitin Ligase Avidly Recognizes Misfolded Proteins through Multiple Substrate Binding Sites

Biomolecules, 2021
Cellular homeostasis depends on robust protein quality control (PQC) pathways that discern misfolded proteins from functional ones in the cell. One major branch of PQC involves the controlled degradation of misfolded proteins by the ubiquitin-proteasome ...
Rebeca Ibarra, Heather R. Borror, Bryce Hart, Richard G. Gardner, Gary Kleiger   +4 more
doaj   +1 more source

The EHEC type III effector NleL is an E3 ubiquitin ligase that modulates pedestal formation. [PDF]

PLoS ONE, 2011
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 causes hemorrhagic colitis and may result in potentially fatal hemolytic uremia syndrome in humans. EHEC colonize the intestinal mucosa and promote the formation of actin-rich pedestals via translocated ...
Heather Piscatelli, Shalaka A Kotkar, Megan E McBee, Sureshkumar Muthupalani, David B Schauer, Robert E Mandrell, John M Leong, Daoguo Zhou   +7 more
doaj   +1 more source

Ubiquitin ligase activity inhibits Cdk5 to control axon termination.

PLoS Genetics, 2022
The Cdk5 kinase plays prominent roles in nervous system development, plasticity, behavior and disease. It also has important, non-neuronal functions in cancer, the immune system and insulin secretion.
Muriel Desbois, Karla J Opperman, Jonathan Amezquita, Gabriel Gaglio, Oliver Crawley, Brock Grill   +5 more
doaj   +1 more source

Genome-Wide Identification of the U-Box E3 Ubiquitin Ligase Gene Family in Cabbage (Brassica oleracea var. capitata) and Its Expression Analysis in Response to Cold Stress and Pathogen Infection

Plants, 2023
Plant U-box E3 ubiquitin ligases (PUBs) play an important role in growth, development, and stress responses in many species. However, the characteristics of U-box E3 ubiquitin ligase genes in cabbage (Brassica oleracea var.
Peiwen Wang, Lin Zhu, Ziheng Li, Mozhen Cheng, Xiuling Chen, Aoxue Wang, Chao Wang, Xiaoxuan Zhang   +7 more
doaj   +1 more source

Role of Nse1 Subunit of SMC5/6 Complex as a Ubiquitin Ligase

Cells, 2022
Structural Maintenance of Chromosomes (SMC) complexes are important for many aspects of the chromosomal organization. Unlike cohesin and condensin, the SMC5/6 complex contains a variant RING domain carried by its Nse1 subunit.
Peter Kolesar, Karel Stejskal, David Potesil, Johanne M. Murray, Jan J. Palecek   +4 more
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G3BP1 modulates SPOP to promote prostate tumorigenesis

Molecular & Cellular Oncology, 2022
Speckle-type POZ protein (SPOP), a Cullin 3-based ubiquitin ligase (CUL3SPOP), acts as a prostate-specific tumor suppressor. Loss-of-function mutations in SPOP occur in 10% of primary prostate cancer with a high Gleason grade and poor prognosis. However,
Chandrani Mukhopadhyay, Pengbo Zhou
doaj   +1 more source

Cbl-c ubiquitin ligase activity is increased via the interaction of its RING finger domain with a LIM domain of the paxillin homolog, Hic 5. [PDF]

PLoS ONE, 2012
Cbl proteins (Cbl, Cbl-b and Cbl-c) are ubiquitin ligases that are critical regulators of tyrosine kinase signaling. In this study we identify a new Cbl-c interacting protein, Hydrogen peroxide Induced Construct 5 (Hic-5).
Philip E Ryan, Stephen C Kales, Rajgopal Yadavalli, Marion M Nau, Han Zhang, Stanley Lipkowitz   +5 more
doaj   +1 more source

Stealing the spotlight: CUL4-DDB1 ubiquitin ligase docks WD40-repeat proteins to destroy

Cell Division, 2007
Recent investigation of Cullin 4 (CUL4) has ushered this class of multiprotein ubiquitin E3 ligases to center stage as critical regulators of diverse processes including cell cycle regulation, developmental patterning, DNA replication, DNA damage and ...
Zhang Hui, Higa Leigh
doaj   +1 more source