Results 111 to 120 of about 327,531 (416)

UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins

Nature Communications, 2018
The U-box ubiquitin ligase UFD-2 is one of the most abundant components of the ubiquitin proteasome system in muscle cells. Here the authors perform in vitro and in vivo experiments and show that UFD-2 has E3 ligase activity and that it ubiquitinates ...
Doris Hellerschmied, Max Roessler, Anita Lehner, Linn Gazda, Karel Stejskal, Richard Imre, Karl Mechtler, Alexander Dammermann, Tim Clausen   +8 more
doaj   +1 more source

Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity

Cell Reports, 2016
Ubiquitin is post-translationally modified by phosphorylation at several sites, but the consequences of these modifications are largely unknown. Here, we synthesize multi-milligram quantities of ubiquitin phosphorylated at serine 20, serine 57, and ...
Nicolas Huguenin-Dezot, Virginia De Cesare, Julien Peltier, Axel Knebel, Yosua Adi Kristaryianto, Daniel T. Rogerson, Yogesh Kulathu, Matthias Trost, Jason W. Chin   +8 more
doaj   +1 more source

Direct observation of silver nanoparticle-ubiquitin corona formation [PDF]

, 2012
Upon entering physiological environments, nanoparticles readily assume the form of a nanoparticle-protein corona that dictates their biological identity. Understanding the structure and dynamics of nanoparticle-protein corona is essential for predicting the fate, transport, and toxicity of nanomaterials in living systems and for enabling the vast ...
arxiv   +1 more source

RNF112 Facilitates Ubiquitin‐Mediated Degradation of c‐Myc, Suppressing Proliferation, Migration and Lipid Synthesis in Bladder Cancer

Advanced Science, EarlyView.
RNF112, an E3 ubiquitin ligase, is markedly reduced in bladder cancer (BLCA). It curbs BLCA cell proliferation, migration, and lipid production primarily by enhancing ubiquitin‐dependent degradation of c‐Myc. This degradation inhibits c‐Myc's role in upregulating ACLY, a crucial enzyme for lipid synthesis, highlighting RNF112's potential as a ...
Kangping Xiong, Siming Chen, Huimin Xu, Sheng Tu, Hong Weng, Yejinpeng Wang, Mingxing Li, Jingtian Yu, Kaiyu Qian, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Gang Wang   +13 more
wiley   +1 more source

Multiple regions of E6AP (UBE3A) contribute to interaction with papillomavirus E6 proteins and the activation of ubiquitin ligase activity.

PLoS Pathogens, 2020
The HECT domain E3 ubiquitin ligase E6AP (UBE3A) is critical for the development of human papillomavirus (HPV) associated cancers, the neurodevelopment disorder Angelman Syndrome, and some cases of autism spectrum disorders.
Camille M Drews, Nicole Brimer, Scott B Vande Pol   +2 more
doaj   +1 more source

Optimal experimental design in an EGFR signaling and down-regulation model [PDF]

arXiv, 2006
We apply the methods of optimal experimental design to a differential equation model for epidermal growth factor receptor (EGFR) signaling, trafficking, and down-regulation. The model incorporates the role of a recently discovered protein complex made up of the E3 ubiquitin ligase, Cbl, the guanine exchange factor (GEF), Cool-1 (Beta-Pix), and the Rho ...
arxiv  

The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex [PDF]

, 2015
The MAGE (Melanoma-associated antigen) protein family members are structurally related to each other by a MAGEhomology domain comprised of 2 winged helix motifs WH/A and WH/B. This family specifically evolved in placental mammals although single homologs
Alan R Lehmann, Chomez P, Christopher M Sanderson, Jan J Palecek, Karel Stejskal, Lucie Kozakova, Lucie Vondrova, Panagoula Charalabous, Peter Kolesar, Shantha Kumara HM, Stjepan Uldrijan, Zbynek Zdrahal   +11 more
core   +3 more sources

CircRNA‐mTOR Promotes Hepatocellular Carcinoma Progression and Lenvatinib Resistance Through the PSIP1/c‐Myc Axis

Advanced Science, EarlyView.
This study verifies that circRNA‐mTOR exhibits high expression levels in HCC and has a strong correlation with patient prognosis. Mechanistically, circRNA‐mTOR achieves this effect by facilitating the nuclear translocation of RNA‐binding protein (RBP) PSIP1 through specific binding.
Yongchang Tang, Feng Yuan, Mingbo Cao, Yupeng Ren, Yuxuan Li, Gaoyuan Yang, Zhaozhong Zhong, Hao Liang, Zhiyong Xiong, Zhiwei He, Nan Lin, Meihai Deng, Zhicheng Yao   +12 more
wiley   +1 more source

RNF122: A novel ubiquitin ligase associated with calcium-modulating cyclophilin ligand

BMC Cell Biology, 2010
Background RNF122 is a recently discovered RING finger protein that is associated with HEK293T cell viability and is overexpressed in anaplastic thyroid cancer cells.
Shi Taiping, Peng Zhi, Ma Dalong
doaj   +1 more source

New force replica exchange method and protein folding pathways probed by force-clamp technique [PDF]

, 2007
We have developed a new extended replica exchange method to study thermodynamics of a system in the presence of external force. Our idea is based on the exchange between different force replicas to accelerate the equilibrium process. We have shown that the refolding pathways of single ubiquitin depend on which terminus is fixed.
arxiv   +1 more source