Results 141 to 150 of about 349,913 (393)

E3 ubiquitin ligases and plant innate immunity [PDF]

, 2009
Andrew W. Craig, Richard Ewan, Joelle Mesmar, Venugopal Gudipati, Ari Sadanandom   +4 more
openalex   +1 more source

Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities

Journal of Medicinal Chemistry, 2014
E3 ubiquitin ligases are attractive targets in the ubiquitin–proteasome system, however, the development of small-molecule ligands has been rewarded with limited success.
C. Galdeano, M. Gadd, P. Soares, S. Scaffidi, I. Van Molle, Ipek Birced, S. Hewitt, David M. Dias, A. Ciulli   +8 more
semanticscholar   +1 more source

Hepatocyte‐Derived Extracellular Vesicles Deliver miR‐328‐3p to Trigger PP2A‐B56δ–Mediated p‐NLRP3S295‐Dependent Metaflammation in Macrophages upon Microcystin‐LR Exposure

Advanced Science, EarlyView.
Hepatocyte‐derived extracellular vesicles deliver miR‐328‐3p to trigger PP2A‐B56δ–mediated p‐NLRP3S295‐dependent metaflammation in macrophages upon microcystin‐LR exposure. 2‐DG, 2‐deoxy‐D‐glucose. B56δ, protein phosphatase 2A‐B56δ. ER, endoplasmic reticulum. iHD‐EV, inducible hepatocyte‐derived extracellular vesicles. IP3R, inositol 1,4,5‐triphosphate
Jia‐Shen Wu, Xin‐Yu Zhang, Xin‐Yu Ma, Yue‐Yue Wei, Lei‐Lei Wang, Ze‐Bang Du, Xiao‐Gang Xia, Lin Che, Dong‐Bei Guo, Han‐Ying Zheng, You‐Liang Yao, Wen‐Gang Li, Yu‐Chun Lin, Zhong‐Ning Lin   +13 more
wiley   +1 more source

HSV-1 ICP0: An E3 Ubiquitin Ligase That Counteracts Host Intrinsic and Innate Immunity

Cells, 2014
The herpes simplex virus type 1 (HSV-1) encoded E3 ubiquitin ligase, infected cell protein 0 (ICP0), is required for efficient lytic viral replication and regulates the switch between the lytic and latent states of HSV-1.
M. P. Lanfranca, H. Mostafa, D. Davido
semanticscholar   +1 more source

METTL10‐Mediated PIAS3 Methylation Links Purine Metabolism to Gastric Cancer Progression

Advanced Science, EarlyView.
METTL10‐mediated methylation of PIAS3 at K442 inhibits its SUMO E3 ligase activity toward MITF. This reduces MITF SUMOylation and subsequent RNF4‐mediated ubiquitination, leading to MITF protein accumulation and gastric cancer progression. Abstract Metabolic dysregulation plays a significant role in the development of gastric cancer (GC).
Jinshui Tan, Huiwen Zhou, Jingsong Ma, Chensong Zhang, Yuhua Tan, Baoding Zhang, Jiabao Zhao, Ao Cheng, Chengyu Yang, Meijuan Xu, Shengyi Zhou, Yubo Xiong, Zeyang Lin, Guangchao Pan, Wenjie Ye, Mengya Zhong, Yang Yang, Yifan Zhuang, Shao‐Wei Li, Xianming Deng, Xuehui Hong   +20 more
wiley   +1 more source

Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection [PDF]

, 2016
Haiyin Liu, Reema Jain, Jing Guan, Vivian Vuong, Satoshi Ishido, Nicole L. La Gruta, Daniel H.D. Gray, Jóse A. Villadangos, Justine D. Mintern   +8 more
openalex   +1 more source

YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination

Advanced Science, EarlyView.
The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu, Wenzhi Du, Yongwen Luo, Jiageng Shi, Tianyun Liu, Meng Ji, Kangping Xiong, Siming Chen, Fenfang Zhou, Mingxing Li, Jingtian Yu, Gang Wang, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Kaiyu Qian   +16 more
wiley   +1 more source

The E3 Ubiquitin Ligase Mind Bomb 1 Controls Adenovirus Genome Release at the Nuclear Pore Complex

Cell Reports, 2019
Summary: Adenoviruses (AdVs) cause respiratory, ocular, and gastrointestinal tract infection and inflammation in immunocompetent people and life-threatening disease upon immunosuppression.
Michael Bauer, Justin W. Flatt, Daria Seiler, Bettina Cardel, Mario Emmenlauer, Karin Boucke, Maarit Suomalainen, Silvio Hemmi, Urs F. Greber   +8 more
doaj   +1 more source

Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection [PDF]

, 2016
Lorenza P. Ferretti, Sarah-Felicitas Himmels, Anika Trenner, Christina Walker, Christine von Aesch, Aline Eggenschwiler, Olga Murina, Radoslav I. Enchev, Matthias Peter, Raimundo Freire, Antônio Porro, Alessandro A. Sartori   +11 more
openalex   +1 more source

Direct observation of autoubiquitination for an integral membrane ubiquitin ligase in ERAD [PDF]

, 2023
Basila Moochickal Assainar, Kaushik Ragunathan, Ryan D. Baldridge   +2 more
openalex   +1 more source