Results 161 to 170 of about 248,165 (360)

Redox Cascade in Chicken Skeletal Muscle: SELENOT Suppression in Selenium Deficiency Triggers Disulfidptosis via mtROS‐NADPH Dysregulation

Advanced Science, EarlyView.
Se deficiency downregulates SELENOT, disrupting mitochondrial function and elevating mtROS to induce glucose metabolic reprogramming, NADPH depletion, cysteine accumulation, and disulfidptosis‐mediated actin cytoskeleton collapse in chicken skeletal muscle.
Huanyi Liu, Hao Wu, Ziyu Zhang, Shiwen Xu, Cong Zhou, Tong Xu   +5 more
wiley   +1 more source

The DSmurf Ubiquitin-Protein Ligase Restricts BMP Signaling Spatially and Temporally during Drosophila Embryogenesis [PDF]

, 2001
Steven D. Podos, Kirsten K. Hanson, Yu‐Chiun Wang, Edwin L. Ferguson   +3 more
openalex   +1 more source

Tumor Intrinsic METTL5 Modulates ATF4 Translation to Prevent T Cell‐Induced Ferroptosis in Ovarian Cancer

Advanced Science, EarlyView.
An integrative analysis combining in vitro genome‐wide immune screens, in vivo ICB screens, and clinical data mining identifies METTL5 as a key tumor‐intrinsic immune factor. Mechanistic studies further reveal the importance of the METTL5‐ATF4‐SLC7A11/SLC3A2‐ferroptosis axis in modulating antitumor immune responses. These findings highlight METTL5 as a
Jiakai Hou, Cheng‐Wei Ju, Nicholas A. Egan, Yanjun Wei, Yunfei Wang, Minghao Dang, Tianyi Zhou, Leilei Shi, Ningbo Zheng, Si Chen, Ashley M. Guerrero, Xiaofang Liang, Wanfu Wu, Areej Akhtar, Chitra Dhiman, Debanwita Roy Burman, Andro E. Gerges, Mason D. Flores, Han Li, Li‐Sheng Zhang, Marleen Kok, Xiaobo Mao, Linghua Wang, Qin Feng, Yiwen Chen, Sanghoon Lee, Daniel J. McGrail, Nidhi Sahni, Chuan He, Amir A. Jazaeri, Weiyi Peng   +30 more
wiley   +1 more source

Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast

, 2000
Fumio Osaka, Mihoro Saeki, Satoshi Katayama, Noriko Aida, Akio Toh‐e, Kin‐ichiro Kominami, Takashi Toda, Toshiaki Suzuki, Tomoki Chiba, Keiji Tanaka, Seishi Kato   +10 more
openalex   +1 more source

Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy [PDF]

, 2001
Sue C. Bodine, Esther Latres, Susanne Baumhueter, Venus Lai, Lorna Nuñez, Brian Clarke, William Poueymirou, Frank J. Panaro, Erqian Na, Kumar Dharmarajan, Zhen‐Qiang Pan, David M. Valenzuela, Thomas M. DeChiara, Trevor N. Stitt, George D. Yancopoulos, David J. Glass   +15 more
openalex   +1 more source

OsNRT1.1B‐OsCNGC14/16‐Ca2+‐OsNLP3 Pathway: Phosphorylation‐Mediated Maintenance of Nitrogen Homeostasis

Advanced Science, EarlyView.
OsNRT1.1B forms a membrane complex with OsCNGC14/16 that mediates nitrate‐triggered calcium influx. This calcium signal phosphorylates OsNLP3 at Ser193, accelerating its nuclear translocation and activating nitrogen‐responsive genes. The calcium‐dependent pathway complements the established ubiquitination‐mediated pathway, dynamically regulating ...
Xiaohan Wang, Yongqiang Liu, Weiwei Li, Xiaojun Ma, Wei Wang, Zhimin Jiang, Yiqin Wang, Legong Li, Bin Hu, Chengcai Chu   +9 more
wiley   +1 more source

Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity [PDF]

, 2001
Heinz Ruffner, Claudio A.P. Joazeiro, Dan Hemmati, Tony Hunter, Inder M. Verma   +4 more
openalex   +1 more source

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

Nature Structural &Molecular Biology, 2016
Ruth M. Densham, Alexander J. Garvin, Helen R. Stone, J. Strachan, R. Baldock, M. Daza-Martin, A. Fletcher, Sarah Blair-Reid, J. Beesley, Balraj Johal, L. Pearl, R. Neely, N. Keep, F. Z. Watts, Joanna R. Morris   +14 more
semanticscholar   +1 more source

Interpretable PROTAC Degradation Prediction With Structure‐Informed Deep Ternary Attention Framework

Advanced Science, EarlyView.
PROTAC‐STAN, a structure‐informed deep learning framework is presented for interpretable PROTAC degradation prediction. By modeling molecular hierarchies and protein structures, and simulating ternary interactions via a novel attention network, PROTAC‐STAN achieves significant performance gains over baselines.
Zhenglu Chen, Chunbin Gu, Shuoyan Tan, Xiaorui Wang, Yuquan Li, Mutian He, Ruiqiang Lu, Shijia Sun, Chang‐Yu Hsieh, Xiaojun Yao, Huanxiang Liu, Pheng‐Ann Heng   +11 more
wiley   +1 more source

Nonperiodic Activity of the Human Anaphase-Promoting Complex–Cdh1 Ubiquitin Ligase Results in Continuous DNA Synthesis Uncoupled from Mitosis

, 2000
Claus Storgaard Sørensen, Claudia Lukas, Edgar R. Kramer, Jan‐Michael Peters, Jiří Bártek, Jiří Lukáš   +5 more
openalex   +1 more source