Results 161 to 170 of about 327,531 (416)
70 MW-level picosecond mid-infrared radiation generation by difference frequency generation in AgGaS2, BaGa4Se7, LiGaSe2, and LiGaS2 [PDF]
IEEE Photonics Journal ( Volume: 17, Issue: 2, April 2025)Comparative study of nonlinear crystals for picosecond difference frequency generation in mid-IR is presented. Nonlinear crystals of AgGaS$_2$, BaGa$_4$Se$_7$, LiGaSe$_2$, and LiGaS$_2$ were studied. Samples of AgGaS$_2$, BaGa$_4$Se$_7$, LiGaSe$_2$, and LiGaS$_2$ were tested in thee sets having lengths of 2, 4, or 8 mm.
arxiv +1 more source
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
Nature, 2015 Protein aggregates and damaged organelles are tagged with ubiquitin chains to trigger selective autophagy. To initiate mitophagy, the ubiquitin kinase PINK1 phosphorylates ubiquitin to activate the ubiquitin ligase parkin, which builds ubiquitin chains ...
M. Lazarou +8 more
semanticscholar +1 more source
Advanced Science, EarlyView.Under DNA damage, tumor cells rely on efficient DNA repair for survival and therapy resistance. This study has demonstrated that BCKDK localizes to breast cancer cell nuclei, where it binds to and phosphorylates RNF8, thereby blocking ubiquitin‐mediated degradation of RAD51 and enhancing HRR. A selective BCKDK inhibitor synergizes with clinical agents,
Haiying Liu +12 more
wiley +1 more source
Energy landscape of ubiquitin modulated by periodic forces: Asymmetric protein stability and shifts in unfolding pathways [PDF]
arXiv, 2008 Biological forces govern essential cellular and molecular processes in all living organisms. Many cellular forces, e.g. those generated in cyclic conformational changes of biological machines, have repetitive components. However, little is known about how proteins process repetitive mechanical stresses.
arxiv
Journal of Medicinal Chemistry, 2014 E3 ubiquitin ligases are attractive targets in the ubiquitin–proteasome system, however, the development of small-molecule ligands has been rewarded with limited success.
C. Galdeano +8 more
semanticscholar +1 more source
Advanced Science, EarlyView.It is shown that obesity is associated with increases in hepatic METTL14 and m6A methylation of G6pc transcript. YTHDF1 and YTHDF3 bind to m6A‐marked G6pc mRNA to increase its synthesis. Hepatocyte‐specific deletion of Mettl14 decreases G6pc m6A methylation, G6pc biosynthesis, and G6pc‐mediated gluconeogenesis, alleviating glucose metabolic defects in ...
Qiantao Zheng +6 more
wiley +1 more source
A mathematical model of p62-ubiquitin aggregates in autophagy [PDF]
arXiv, 2020 Aggregation of ubiquitinated cargo by oligomers of the protein p62 is an important preparatory step in cellular autophagy. In this work a mathematical model for the dynamics of these heterogeneous aggregates in the form of a system of ordinary differential equations is derived and analyzed. Three different parameter regimes are identified, where either
arxiv
MNF, an ankyrin repeat protein of myxoma virus, is part of a native cellular SCF complex during viral infection [PDF]
, 2010 Myxoma virus (MYXV), a member of the Poxviridae family, is the agent responsible for myxomatosis, a fatal disease in the European rabbit (Oryctolagus cuniculus).
Bertagnoli, Stéphane +3 more
core +3 more sources
HSV-1 ICP0: An E3 Ubiquitin Ligase That Counteracts Host Intrinsic and Innate Immunity
Cells, 2014 The herpes simplex virus type 1 (HSV-1) encoded E3 ubiquitin ligase, infected cell protein 0 (ICP0), is required for efficient lytic viral replication and regulates the switch between the lytic and latent states of HSV-1.
M. P. Lanfranca, H. Mostafa, D. Davido
semanticscholar +1 more source
Advanced Science, EarlyView.Ethylene‐activated MdEAEL1 mediates the disassembly of the MdZFP3‐MdTPL4‐MdHDA19 transcriptional repression complex, upregulating the histone acetylation levels in the promoter regions of cell wall degradation‐related genes, consequently promoting softening during storage.
Tong Li +8 more
wiley +1 more source