Results 181 to 190 of about 133,567 (215)

Lipidating a ubiquitin ligase

Science Signaling, 2019
A previously undescribed enzyme promotes lipidation of a ubiquitin ligase that regulates PI3K and Ca 2+ signaling.
openaire   +2 more sources

Ubiquitin Ligases and the Immune Response

Annual Review of Immunology, 2004
Ubiquitin (Ub)-protein conjugation represents a novel means of posttranscriptional modification in a proteolysis-dependent or -independent manner. E3 Ub ligases play a key role in governing the cascade of Ub transfer reactions by recognizing and catalyzing Ub conjugation to specific protein substrates.
openaire   +2 more sources

Ubiquitin Ligases and Cancer

2009
Ubiquitin E3 ligases are the most prevalent cancer genes besides protein kinases, suggesting a critical role in cancer development and progression. Two major classes of E3 ligases can be distinguished: the HECT-type and the adaptor-type E3s. The latter include RING-finger, PHD, and U-box domain ligases.
Angelika M. Burger, Arun K. Seth
openaire   +2 more sources

Ubiquitination on Nonlysine Residues by a Viral E3 Ubiquitin Ligase

Science, 2005
Ubiquitination controls a broad range of cellular functions. The last step of the ubiquitination pathway is regulated by enzyme type 3 (E3) ubiquitin ligases. E3 enzymes are responsible for substrate specificity and catalyze the formation of an isopeptide bond between a lysine residue of the substrate (or the N terminus of the substrate ...
Ken Cadwell, Laurent Coscoy
openaire   +3 more sources

Parkin: a multifaceted ubiquitin ligase

Biochemical Society Transactions, 2006
Mutations in the parkin gene are a common cause of autosomal recessive early-onset parkinsonism. Parkin functions as an E3 ubiquitin ligase where it can polyubiquitinate a number of its protein substrates, thus targeting them for degradation by the 26 S proteasomal complex.
openaire   +3 more sources

RNF220, an E3 ubiquitin ligase that targets Sin3B for ubiquitination

Biochemical and Biophysical Research Communications, 2010
Modification of proteins by ubiquitination plays important roles in various cellular processes. During this process, the target specificity is determined by ubiquitin ligases. Here we identify RNF220 (RING finger protein 220) as a novel ubiquitin ligase for Sin3B. As a conserved RING protein, RNF220 can bind E2 and mediate auto-ubiquitination of itself.
Qinghua Kong, Wanli Zeng, Wanli Zeng, Chaocui Li, Bingyu Mao, Wanling Hu, Wanling Hu, Jingyang Wu, Jingyang Wu   +8 more
openaire   +3 more sources

Monitoring MHC Ubiquitination by MARCH Ubiquitin Ligases

2019
Ubiquitination is a reversible process that controls the intracellular transport of many transmembrane molecules. Ubiquitination of MHC I, MHC II, and CD1a by different members of the MARCH family of E3 ubiquitin ligases is a key event in the regulation of the potent immunostimulatory properties of activated dendritic cells. We describe here methods to
openaire   +3 more sources

E3 ubiquitin ligases for MHC molecules

Current Opinion in Immunology, 2009
Recently, novel E3 ubiquitin ligases that target MHC molecules for lysosomal degradation have been discovered by several groups. All these E3s are membrane-bound and possess a variant type RING domain, termed the RING-CH or RING variant (RINGv) domain. They belong to a new E3 family designated Modulator of Immune Recognition (MIR), based on the name of
Satoshi Ishido, Eiji Goto, Yohei Matsuki, Mari Ohmura-Hoshino   +3 more
openaire   +3 more sources

Vimentin is a ubiquitination and degradation substrate of the ubiquitin ligase KPC1

Biochemical and Biophysical Research Communications
The ubiquitin proteasome system (UPS), driven by ubiquitin as a degradation signal, eliminates, in a highly specific manner, 'abnormal' proteins and proteins that completed their function. This process involves a hierarchical cascade of E1, E2, and E3 enzymes. The E3 ubiquitin ligases, act as specific receptors that bind their cognate substrates.
Yossi Gottfried, Chen Lulu-Shimron, Gilad Goldhirsh, Yael Fisher, Tamar Ziv, Dave S.B. Hoon, Yelena Kravtsova-Ivantsiv, Aaron Ciechanover   +7 more
openaire   +2 more sources

Ubiquitin Ligase RBX2/SAG Regulates Mitochondrial Ubiquitination and Mitophagy

Circulation Research
BACKGROUND: Clearance of damaged mitochondria via mitophagy is crucial for cellular homeostasis. Apart from Parkin, little is known about additional Ub (ubiquitin) ligases that mediate mitochondrial ubiquitination and turnover, particularly in highly metabolically active organs such as the heart.
Wenjuan Wang, Ermin Li, Jianqiu Zou, Chen Qu, Juan Ayala, Yuan Wen, Md Sadikul Islam, Neal L. Weintraub, David J.R. Fulton, Qiangrong Liang, Jiliang Zhou, Jinbao Liu, Jie Li, Yi Sun, Huabo Su   +14 more
openaire   +3 more sources