Results 181 to 190 of about 254,188 (362)

The SCF Ubiquitin Ligase [PDF]

Molecular Cell, 2002
Jackson, Peter K, Eldridge, Adam G
openaire   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

The E3 ubiquitin ligase FBXL18 stabilizes BST2 to promote inflammation in RABV-infected astrocytes. [PDF]

Nat Commun
Wang J, Guo J, Li N, Tu Z, Liu S, Ma J, Zhang X, Cheng H, Hao Z, Feng Y, Lv S, Tai G, Zhou Y, Fu J, Tu C, Liu Y.   +15 more
europepmc   +1 more source

Ubiquitin Protein Ligase [PDF]

, 2020
openaire   +1 more source

Pan2‐Pan3 Complex‐Mediated Deadenylation Enforces mRNA Quality Control for Infection of the Rice Blast Fungus

Advanced Science, EarlyView.
Discovery that deadenylation, rather than transcription, acts as the rate‐limiting step for developmental timing in a plant pathogen. Evidence that P‐body integrity and mRNA decay are mechanistically coupled to rapid cellular differentiation under environmental stress. Identification of Pan2‐Pan3 as a pathogen‐specific “meta‐virulence factor” absent in
Ziwei Lv, Junting Feng, Shenxian Zhou, Zhiguang Qu, Jun Peng, Xiao‐Lin Chen, Deng Chen   +6 more
wiley   +1 more source

Drosophila Roc1a Encodes a RING-H2 Protein with a Unique Function in Processing the Hh Signal Transducer Ci by the SCF E3 Ubiquitin Ligase

, 2021
Maher Noureddine, Timothy Donaldson, Stephen B. Thacker, Robert J. Duronio   +3 more
openalex   +1 more source

Epidermal Cell Dynamics Regulates Rice Lamina Joint Morphogenesis and Leaf Angle Formation through OsZHD1 and OsZHD2 Regulation

Advanced Science, EarlyView.
The lamina joint determines leaf angle and plant architecture. Xu et al. establish a live‐imaging system for the rice lamina joint and reveal that asymmetric epidermal cell elongation and division between the lateral and medial edges drive leaf angle formation.
Yiru Xu, Heng Zhou, Xiaojiang Wu, Wuyu Cui, Shouling Xu, Xi He, Dan Xiang, Ming Zhou, Xiuqin Rao, Lilan Hong   +9 more
wiley   +1 more source

Proteomic Analysis of Ubiquitin Ligase KEAP1 Reveals Associated Proteins That Inhibit NRF2 Ubiquitination [PDF]

, 2013
Bridgid E. Hast, Dennis Goldfarb, Kathleen M. Mulvaney, Michael A. Hast, Priscila F. Siesser, Feng Yan, D. Neil Hayes, Michael B. Major   +7 more
openalex   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Regulation of PD-L1 Protein Expression by the E3 Ubiquitin Ligase GP78. [PDF]

Curr Issues Mol Biol
Chatterjee M, Pimentel JM, Zhou JY, Mugunamalwaththa T, Yang Z, Raz A, Wu GS.   +6 more
europepmc   +1 more source