Results 201 to 210 of about 254,188 (362)

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

The E3 ubiquitin ligase Trip12 semi-selectively attenuates Wnt signaling. [PDF]

iScience
Ensing J, Ide AD, Gilliland C, Tsurho V, Rudisel E, Caza I, Stratman AN, Lanning NJ, Grainger S.   +8 more
europepmc   +1 more source

Repression of Transcriptional Activity of Estrogen Receptor a by α Cullin3/SPOP Ubiquitin E3 Ligase Complex

, 2008
Boohyeong Byun, Yunhwa Jung
openalex   +1 more source

The promotional effect of microRNA-103a-3p in cervical cancer cells by regulating the ubiquitin ligase FBXW7 function

, 2022
Li Ren, Jinjin Yang, Xiyan Meng, Junjun Zhang, Yiran Zhang   +4 more
openalex   +1 more source

Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase

Cell, 2015
Carlos T Pineda, Saumya Ramanathan, K. F. Tacer, J. Weon, Malia B. Potts, Yi-Hung Ou, M. White, P. R. Potts   +7 more
semanticscholar   +1 more source

Bioorthogonal Sonodynamic Plug‐and‐Play Targeting Chimeras (SDPTAC) for Precise Targeted Protein Degradation

Advanced Science, EarlyView.
Bioorthogonal SDPTAC harnesses US‐responsive Ce6‐TCO and Tz ligands via IEDDA click chemistry to assemble degraders in situ, generating ROS that selectively eliminate nuclear, cytosolic, and membrane proteins, thereby suppressing deep‐seated tumors in vivo.
Yuhan Bao, Yaojin Zhu, Xinhao Wei, Yuxin Fang, Jiayi Zhu, Fei Gao, Guoqiang Dong, Shipeng He, Chunquan Sheng   +8 more
wiley   +1 more source

Exploring the Mechanisms, Biomarkers, and Therapeutic Targets of TRIM Family in Gastrointestinal Cancer

Drug Design, Development and Therapy
Chunyan Weng,1,* Rijuan Jin,1,* Xiaoliang Jin,1,* Zimei Yang,1,* Chenghai He,1,2 Qiuhua Zhang,1 Jingli Xu,1,3 Bin Lv1 1Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang ...
Weng C, Jin R, Jin X, Yang Z, He C, Zhang Q, Xu J, Lv B   +7 more
doaj  

The CTLH ubiquitin ligase substrates ZMYND19 and MKLN1 negatively regulate mTORC1 at the lysosomal membrane. [PDF]

Nat Commun
Wang Y, Liao Y, Sun Y, Mitra B, Guo R, Piedras BI, White S, Tang HY, Asara JM, Tempera I, Lieberman PM, Gewurz BE.   +11 more
europepmc   +1 more source

Molecular insights into degron recognition by CRL5ASB7 ubiquitin ligase [PDF]

Mengyu Zhou, Xiaolu Wang, Jiangtao Li, Jinfeng Ma, Ziyu Bao, Xiaojie Yan, Bing Zhang, Tong Liu, Ying Yu, Wenyi Mi, Dong Cheng   +10 more
openalex   +1 more source

The RNA Surveillance Factor UPF1 Represses Myogenesis via Its E3 Ubiquitin Ligase Activity [PDF]

, 2017
Qing Feng, Sujatha Jagannathan, Robert K. Bradley   +2 more
openalex   +1 more source