Results 201 to 210 of about 232,343 (304)

E3 ubiquitin ligase; SMAD specific E3 ubiquitin protein ligase 2 (SMURF2); NEDD4 family E3 ubiquitin-protein ligase (RSP5) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

Nuclear Entanglement: New Insights Into the Role of Cytoskeleton and Nucleoskeleton in Plant Nuclear Function

Cytoskeleton, EarlyView.
ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves, Katelyn Amstutz, Lily A. Schumacher, Iris Meier   +3 more
wiley   +1 more source

E3 ubiquitin ligases ubiquitinate target proteins

Reactome - a curated knowledgebase of biological pathways, 2016
openaire   +1 more source

Evaluating Transcriptomic Biomarkers for rHuEPO Detection: Assessing the Impact of Exercise and Altitude Exposure

Drug Testing and Analysis, EarlyView.
A two‐stage transcriptomic filter comparing rHuEPO, exercise and altitude responses reduced 153 candidate genes to 50 that were unaffected by physiological stimuli. These retained transcripts offer focused biomarker leads to strengthen antidoping detection of rHuEPO.
Daria Obratov, Shaun Sutehall, Longhua Liu, Zhao Zhongying, Yannis Pitsiladis   +4 more
wiley   +1 more source

Balancing rice blast resistance and growth through suppression of the E3 ubiquitin ligase OsRING80. [PDF]

Plant Physiol
Hou X, You X, Mi X, Huang X, Hu H, Wang J, He F, Wang R, Wang S, Ning Y.   +9 more
europepmc   +1 more source

Protein turnover downstream of the Nipbl/CRL4 axis contributes to abnormal development in zebrafish embryos

Developmental Dynamics, EarlyView.
Abstract Background Mutations in cohesins cause cohesinopathies such as Cornelia de Lange Syndrome (CdLS) and Roberts Syndrome (RBS). Prior findings demonstrate that Esco2 (a cohesin activator) and Smc3 (a core cohesin subunit) regulate the CRL4 E3 ubiquitin ligase. SMC3 mutations, however, account for a small percentage of CdLS.
Annie C. Sanchez, Niusha Banoukh, Fiona Mensching, Robert V. Skibbens, M. Kathryn Iovine   +4 more
wiley   +1 more source

The E3 ubiquitin ligase Trip12 semi-selectively attenuates Wnt signaling. [PDF]

iScience
Ensing J, Ide AD, Gilliland C, Tsurho V, Rudisel E, Caza I, Stratman AN, Lanning NJ, Grainger S.   +8 more
europepmc   +1 more source

Isolated absence epilepsy associated with a de novo FBXW7 missense variant in the F‐box domain

Epilepsia Open, EarlyView.
Abstract The FBXW7 gene encodes a substrate‐recognition component of the Skp1‐Cul1‐F‐box (SCF) E3 ubiquitin ligase complex, which targets key regulatory proteins for proteasomal degradation. Recently, loss‐of‐function FBXW7 variants have been associated with a novel neurodevelopmental disorder characterized by heterogeneous clinical features.
Anees Muhammad, Mohammad Sadegh Shams Nosrati, Alireza Dostmohammadi, Francesca Madia, Maria Margherita Mancardi, Stefania Fornarino, Luca Bosisio, Zahra Hoseini Tavassol, Mir Davood Omrani, Federico Zara, Marcello Scala   +10 more
wiley   +1 more source

Structural basis for fork reversal and RAD51 regulation by the SCF ubiquitin ligase complex of F-box helicase 1. [PDF]

Nat Commun
Greer BH, Mendia-Garcia J, Mullins EA, Peacock EM, Haigh SK, Schiltz CJ, Aicart-Ramos C, Tsai MS, Cortez D, Moreno-Herrero F, Eichman BF.   +10 more
europepmc   +1 more source

The CTLH ubiquitin ligase substrates ZMYND19 and MKLN1 negatively regulate mTORC1 at the lysosomal membrane. [PDF]

Nat Commun
Wang Y, Liao Y, Sun Y, Mitra B, Guo R, Piedras BI, White S, Tang HY, Asara JM, Tempera I, Lieberman PM, Gewurz BE.   +11 more
europepmc   +1 more source