Results 201 to 210 of about 248,165 (360)

The E3 ubiquitin ligase MARCH9 alleviates pyroptosis by regulating NLPR3 ubiquitination following myocardial ischemia reperfusion. [PDF]

Cell Mol Life Sci
Lu H, Ma G, Ding C, Wang P, Ruan Q, Zeng Y, Ma L, Lu M, Li Y, Sun W.   +9 more
europepmc   +1 more source

Membrane Topology and Function of Der3/Hrd1p as a Ubiquitin-Protein Ligase (E3) Involved in Endoplasmic Reticulum Degradation [PDF]

, 2001
Péter Deák, Dieter H. Wolf
openalex   +1 more source

ACE‐mediated Glycosylation Stabilizes PSAP To Promote GPR37‐dependent Macrophage‐Nucleus Pulposus Cells Crosstalk and TGFβ Signaling in Alleviating Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ACE can modulate the CBL‐mediated K48 ubiquitination degradation of PSAP by altering its glycosylation levels in NP cells. As a result, NP cells secrete PSAP, which interacts with GPR37 on macrophage surfaces, facilitating their polarization toward the M2 phenotype. These M2 macrophages subsequently secrete TGFβ, which exerts feedback effects on the NP
Youfeng Guo, Feng Wang, Bijun Wang, Yu Zhou, Chao Wang, Tao Hu, Desheng Wu   +6 more
wiley   +1 more source

Arylsulfatase B induces melanoma apoptosis by the ubiquitin ligase COP1. [PDF]

J Biol Chem
Bhattacharyya S, O-Sullivan I, Whiteley HE, Yang J, Zhang F, Tobacman JK.   +5 more
europepmc   +1 more source

Kinetic Analysis of the Conjugation of Ubiquitin to Picornavirus 3C Proteases Catalyzed by the Mammalian Ubiquitin-protein Ligase E3α [PDF]

, 2001
T. Glen Lawson, Molly E. Sweep, Peter E. Schlax, Richard N. Bohnsack, Arthur L. Haas   +4 more
openalex   +1 more source

Enhanced Selenium Supplement Extends Lifespan and Delays Multi‐Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis

Advanced Science, EarlyView.
Aging involves physiological decline and heightened disease susceptibility, necessitating effective interventions. Redox‐responsive selenium‐loaded nanoparticles (SeMSNs) are developed, which delay cellular senescence by reducing oxidative stress and senescence markers (p16/p21). In aged mice, SeMSNs extend lifespan, improve organ function, and restore
Yang Yu, Jintao Song, Mengjiao Guo, RuZe Ma, Mingyang Du, Zhe Xun, Xu Liu, RongXia Xu, Xiaochun Xie, Peilin Qi, Yujie Chen, Dan Shao, Chao Yang, Liang Wang, Xiaoyu Song, Difei Wang   +15 more
wiley   +1 more source

Reduced Pressure Ionization Enhances Native Mass Spectrometry of Proteins and Protein Complexes

Angewandte Chemie, EarlyView.
Reduced pressure for electrospray ionization of native proteins narrows peak widths and increases signal. This straightforward add‐on to existing native MS platforms improves performance in challenging buffers and enables detection of protein interactions at concentrations as low as 50 nM, without significantly disrupting structure as confirmed by ...
Jake P. Violi, Chong Zhang, William A. Donald   +2 more
wiley   +2 more sources

Deletion of the E3 ubiquitin ligase LRSAM1 fosters intracellular <i>Staphylococcus aureus</i> survival. [PDF]

Front Cell Infect Microbiol
Plöhn O, Singh AK, Greger C, Wolfgramm H, Baglanova M, Surmann K, Völker U, Bröker BM, Becker K, Seifert U, Cammann C.   +10 more
europepmc   +1 more source

Combinatorial diversity of fission yeast SCF ubiquitin ligases by homo- and heterooligomeric assemblies of the F-box proteins Pop1p and Pop2p. [PDF]

, 2002
Volker Seibert, Corinna Prohl, Ida Schoultz, Edward K. Rhee, Rebecca Lopez, Kareem Abderazzaq, Chunshui Zhou, Dieter A Wolf   +7 more
openalex   +1 more source

Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase

Cell, 2015
Carlos T Pineda, Saumya Ramanathan, K. F. Tacer, J. Weon, Malia B. Potts, Yi-Hung Ou, M. White, P. R. Potts   +7 more
semanticscholar   +1 more source