Medicinal Research Reviews, Volume 43, Issue 1, Page 237-287, January 2023., 2023 Abstract The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein homeostasis, among other processes.
Enrique Crisman +6 more
wiley +1 more source
A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling
Cell Reports, 2018 Summary: Ubiquitination is essential for protein degradation and signaling and pivotal to many physiological processes. Ubiquitination of a subset of G-protein-coupled receptors (GPCRs) by the E3 ligase NEDD4-2 is required for p38 activation, but how ...
Neil J. Grimsey +10 more
doaj
Regulation of the cardiac voltage‐gated Na+ channel (H1) by the ubiquitin‐protein ligase Nedd4 [PDF]
, 2000 Hugues Abriel +3 more
openalex +1 more source
Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology
Angewandte Chemie International Edition, Accepted Article.Targeted protein degradation (TPD) has emerged as a transformative therapeutic strategy for eliminating disease‐associated proteins, with relevance across disorders ranging from cancer to neurodegeneration. Since its inception nearly two decades ago, TPD has attracted strong academic and commercial interest, with multiple candidates advancing into ...
Andrew G. Baker +3 more
wiley +1 more source
A putative ubiquitin ligase required for efficient mRNA export differentially affects hnRNP transport [PDF]
, 2000 Kent E. Duncan +2 more
openalex +1 more source
Development of an Organoautocatalyzed Double σ‐Bond C(sp2)‐N Transamination Metathesis Reaction
Angewandte Chemie International Edition, Accepted Article.The transamination reaction, which involves the conversion of one amine to another, traditionally relies on biological enzyme catalysts. Although chemists have recently developed a few transition metal‐catalyzed methods, mimicking these enzymes to interconvert amine groups in acyclic substrates via transamination metathesis of a single C(sp2)–N bond ...
Volker Klein +7 more
wiley +1 more source
NEDD4 family E3 ligases in osteoporosis: mechanisms and emerging potential therapeutic targets
Journal of Orthopaedic Surgery and ResearchOsteoporosis is a systemic skeletal disorder characterized by reduced bone density and an increased risk of fractures, particularly prevalent in the aging population.
Heng Wu +4 more
doaj +1 more source
Role of the ubiquitin-selective CDC-48/UFD-1/NPL-4 chaperone in DNA replication [PDF]
, 2012 Faithful transmission of genomic information requires tight spatiotemporal regulation of DNA replication factors. Posttranslational modifications, such as ubiquitylation, constitute a fast and effective mechanism to control such complex protein function.
Franz, André
core
Rsp5, a Ubiquitin-Protein Ligase, Is Involved in Degradation of the Single-Stranded-DNA Binding Protein Rfa1 in Saccharomyces cerevisiae [PDF]
, 2000 Naz Erdeniz, Rodney Rothstein
openalex +1 more source