Advanced Science, EarlyView.Marker metabolite‐based multi‐omics (genome, transcriptome, and metabolome) analysis is conducted firstly to unravel the genetic basis of thousand seed weight (TSW) in Brassica napus. The released metabolite‐QTL‐gene network represents a valuable genetic resource, and the newly validated BnaTGA6 is a promising target for the improvement of TSW in ...
Long Li +10 more
wiley +1 more source
Genome-wide analysis of the RING-H2 E3 ubiquitin ligase SlATL family in tomato. [PDF]
Sci RepKong X +7 more
europepmc +1 more source
The SCFCOI1 Ubiquitin-Ligase Complexes Are Required for Jasmonate Response in Arabidopsis [PDF]
, 2002 Linghui Xu +8 more
openalex +1 more source
Mechanism of Lenvatinib Resistance via Exosomal miRNA‐132/Nrf2 Axis in Hepatocellular Carcinoma
Annals of Gastroenterological Surgery, EarlyView.Exosomal miRNA‐132 from LVT‐res HCC cells activated Nrf2 expression through the PTEN/GSK3β pathway in recipient cells. This cascade could induce drug resistance in non‐resistant HCC cells in the TME. ABSTRACT Introduction Lenvatinib is a multiple receptor tyrosine kinase inhibitor and a first‐line targeted therapy for hepatocellular carcinoma (HCC ...
Chie Takasu +7 more
wiley +1 more source
E3 ubiquitin ligases ubiquitinate target proteins
Reactome - a curated knowledgebase of biological pathways, 2016 B May, JE Azevedo
openaire +2 more sources
The ubiquitin ligase Triad1 influences myeloid leukemogenesis by regulating the integrated stress response. [PDF]
J Biol ChemWang H +10 more
europepmc +1 more source
Development of an efficient mice model of cancer‐associated cardiac cachexia
Animal Models and Experimental Medicine, EarlyView.This work establishes a preclinical framework for targeting ubiquitin pathways to mitigate the morbidity of cancer‐related cardiopathy. Our integrated approach delineates a hierarchical progression from subcellular dysfunction to macroscopic cardiac deterioration. These findings mechanistically link tumor‐induced cachexia to cardiac dysfunction through
Shijie Xiong +9 more
wiley +1 more source
The ubiquitin ligase NKLAM promotes apoptosis and suppression of cell growth. [PDF]
J Biol ChemWillard PA, Kornbluth J.
europepmc +1 more source
PJA1, Encoding a RING-H2 Finger Ubiquitin Ligase, Is a Novel Human X Chromosome Gene Abundantly Expressed in Brain [PDF]
, 2002 Ping Yu +3 more
openalex +1 more source
Advances in miRNA research: Unraveling the complexities of gene regulation
Animal Models and Experimental Medicine, EarlyView.Overview of miRNA‐mediated regulation in key biological processes. This illustration offers a comprehensive view of the diverse functions that microRNAs perform in governing various biological processes, highlighting their profound significance within the complex web of gene expression and cellular function.
Jiawei Zheng, Guoqing Zhang, Linzhu Ren
wiley +1 more source