Results 241 to 250 of about 349,913 (393)

Sorafenib promotes the E3 ubiquitin ligase FBXW7 to increase tau degradation and ameliorate tauopathies. [PDF]

Acta Pharm Sin B
Zhou Y, Wang Y, Yang H, Zhang C, Meng J, Zhang L, Li K, Huang LL, Zhang X, Luo H, Zhang Y.   +10 more
europepmc   +1 more source

Deletion of the E3 ubiquitin ligase MARCH1 promotes white adipose tissue beiging and attenuates diastolic dysfunction in a multi-hit mouse model of heart failure with preserved ejection fraction [PDF]

Y.L. Zhu, H. Yang, J. Fan, S.H. Zhou, JP(曾寄萍) Zeng, H. B. Huang, Wu Mx   +6 more
openalex   +1 more source

The RING Finger Ubiquitin E3 Ligase OsHTAS Enhances Heat Tolerance by Promoting H2O2-Induced Stomatal Closure in Rice1

Plant Physiology, 2015
Jianping Liu, Cuicui Zhang, Chuchu Wei, Xin Liu, Mugui Wang, Feifei Yu, Q. Xie, J. Tu   +7 more
semanticscholar   +1 more source

Targeting the Dynamics Between TAMs and CAR‐T Cells in Solid Tumor Therapies

Advanced Science, EarlyView.
This review highlights the critical role of tumor‐associated macrophages (TAMs) in affecting CAR‐T cell therapy effectiveness in solid tumors. TAMs contribute to immune suppression through cytokine secretion, immune checkpoint activation, and metabolic reprogramming, leading to CAR‐T cell exhaustion and reduced efficacy. The article explores strategies
Xiang Zhang, Hao Zheng, Zi‐Chang Liu, Ling‐Jie Luo, Xiao Dong, Xin‐Gang Cui, Yan‐Wei Wu, Liang Chen   +7 more
wiley   +1 more source

The E3 ubiquitin ligase STUB1 inhibits Senecavirus A replication by mediating VP1 ubiquitination and proteasomal degradation. [PDF]

J Virol
Zeng P, Mao J, Guo J, Yang X, Shi Y, Wang X, Song J, Zhou J, Hou L, Liu J.   +9 more
europepmc   +1 more source

The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A

Juan Andres Kochen Rossi, Cristina Nuevo‐Tapioles, Rachel A. O’Keefe, Moritz Hunkeler, Anna M. Schmoker, Mercedes Fissore-O'Leary, Wenjuan Su, Ian M. Ahearn, Cristina Branco, Hakyung Cheong, Dominic Esposito, Ioana Clotea, Beatrix Ueberheide, Eric S. Fischer, Mark R. Philips   +14 more
openalex   +1 more source

Supplementary Fig 7 from Ubiquitin Ligases Siah1a/2 Control Alveolar Macrophage Functions to Limit Carcinogen-Induced Lung Adenocarcinoma [PDF]

Marzia Scortegagna, Yuanning Du, Linda M. Bradley, Kun Wang, Alfredo Molinolo, Eytan Ruppin, Rabi Murad, Ze'ev A. Ronai   +7 more
openalex   +1 more source

Publisher's Note: Cilia-localized GID/CTLH ubiquitin ligase complex regulates protein homeostasis of sonic hedgehog signaling components

, 2022
Friederike Hantel, Huaize Liu, Lisa Fechtner, Herbert Neuhaus, Jie Ding, Danilo Arlt, Peter Walentek, Pablo Villavicencio‐Lorini, Christoph Gerhardt, Thomas Hollemann, Thorsten Pfirrmann   +10 more
openalex   +2 more sources

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Arylsulfatase B induces melanoma apoptosis by the ubiquitin ligase COP1. [PDF]

J Biol Chem
Bhattacharyya S, O-Sullivan I, Whiteley HE, Yang J, Zhang F, Tobacman JK.   +5 more
europepmc   +1 more source