Inheritance of the Golgi Apparatus and Cytokinesis Are Controlled by Degradation of GBF1
Cell Reports, 2018 Summary: Although much is known about how chromosome segregation is coupled to cell division, how intracellular organelles partition during mitotic division is poorly understood. We report that the phosphorylation-dependent degradation of the ARFGEF GBF1
Roberto Magliozzi +9 more
doaj
PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27KIP1 through the ubiquitin E3 ligase SCFSKP2 [PDF]
, 2001 Ramanaiah Mamillapalli +6 more
openalex +1 more source
HN1 expression contributes to mitotic fidelity through Aurora A‐PLK1‐Eg5 axis
Cytoskeleton, EarlyView.Abstract Hematological and neurological expressed 1 (HN1) is homolog of Jupiter protein from Drosophila melanogaster where it functions as a microtubule‐associated protein. However, in mammalian cells, HN1 is associated partially with y‐tubulin in centrosomes, Stathmin for stabilizing microtubules, and Cdh1 for regulating Cyclin B1 for cell cycle ...
Gülseren Özduman +3 more
wiley +1 more source
Emerging roles of BET proteins in transcription and co‐transcriptional RNA processing
WIREs RNA, Volume 14, Issue 1, January/February 2023., 2023 Roles of BET proteins in RNA polymerase II transcription and co‐transcriptional RNA processing. Abstract Transcription by RNA polymerase II (Pol II) gives rise to all nuclear protein‐coding and a large set of non‐coding RNAs, and is strictly regulated and coordinated with RNA processing.
Nicole Eischer +2 more
wiley +1 more source
Proteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma virus and are required for gag budding from cells [PDF]
, 2001 Alexandra Kikonyogo +6 more
openalex +1 more source
PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential
Cytoskeleton, EarlyView.ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Muhammad Hamzah +2 more
wiley +1 more source
Reprograming of proteasomal degradation by branched chain amino acid metabolism
Aging Cell, Volume 21, Issue 12, December 2022., 2022 Using genetics and multi‐omics analyses in Caenorhabditis elegans, we identified adaptive regulation of the ubiquitin‐proteasome system (UPS) in response to defective branched chain amino acid (BCAA) metabolism. Worms with impaired BCAA metabolism show slower turnover of a GFP‐based proteasome substrate, which is suppressed by loss‐of‐function of the ...
Sonia Ravanelli +5 more
wiley +1 more source
Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.
Chemistry and Biology, 2015 Jing Lu +10 more
semanticscholar +1 more source
APC2 Cullin Protein and APC11 RING Protein Comprise the Minimal Ubiquitin Ligase Module of the Anaphase-promoting Complex [PDF]
, 2001 Zhanyun Tang +7 more
openalex +1 more source