Results 241 to 250 of about 254,188 (362)

E3 ubiquitin ligases ubiquitinate target proteins

Reactome - a curated knowledgebase of biological pathways, 2016
openaire   +1 more source

Nuclear Entanglement: New Insights Into the Role of Cytoskeleton and Nucleoskeleton in Plant Nuclear Function

Cytoskeleton, EarlyView.
ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves, Katelyn Amstutz, Lily A. Schumacher, Iris Meier   +3 more
wiley   +1 more source

Correction to "Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability". [PDF]

Nucleic Acids Res
europepmc   +1 more source

The ubiquitin ligase RCBTB2 regulates aggrephagy and inhibits prostate cancer progression by targeting GPAA1 for degradation. [PDF]

Am J Cancer Res
Mo R, Chi N, Du J, Li X, Guo W, Li H, Wang J, Cai C, Li S, Liu C.   +9 more
europepmc   +1 more source

A role for the C2 domain of the ubiquitin-protein ligase Nedd4 [PDF]

, 2000
Pamela Plant
openalex  

A Facile Protocol for C(sp2)–C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands

ChemMedChem, EarlyView.
A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Anita Maksutova, Thomas M. Geiger, Lorenzo Cianni, Dominika E. Pieńkowska, Jan Gerhartz, Lina Read, Aleša Bricelj, Alexander Herrmann, Maurice Leon Nelles, Yuen Lam Dora Ng, Marcus D. Hartmann, Jan Krönke, Izidor Sosič, Radosław P. Nowak, Michael Gütschow, Christian Steinebach   +15 more
wiley   +1 more source

Structural basis for E3 ubiquitin ligase UHRF1 binding to nucleosome core particle and histone H3 ubiquitination. [PDF]

J Biol Chem
Shikimachi R, Matsuzawa S, Onoda H, Konuma T, Yamagata A, Shirouzu M, Yamaguchi K, Arita K.   +7 more
europepmc   +1 more source

The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis

Nature Communications, 2014
P. Xie, Minghua Zhang, Shan He, Kefeng Lu, Yuhan Chen, G. Xing, Yiming Lu, Ping Liu, Yang Li, Shaoxia Wang, N. Chai, Jiawei Wu, Haiteng Deng, Hong-Rui Wang, Yu Cao, Fei Zhao, Yu Cui, Jian Wang, F. He, Lingqiang Zhang   +19 more
semanticscholar   +1 more source

Protein turnover downstream of the Nipbl/CRL4 axis contributes to abnormal development in zebrafish embryos

Developmental Dynamics, EarlyView.
Abstract Background Mutations in cohesins cause cohesinopathies such as Cornelia de Lange Syndrome (CdLS) and Roberts Syndrome (RBS). Prior findings demonstrate that Esco2 (a cohesin activator) and Smc3 (a core cohesin subunit) regulate the CRL4 E3 ubiquitin ligase. SMC3 mutations, however, account for a small percentage of CdLS.
Annie C. Sanchez, Niusha Banoukh, Fiona Mensching, Robert V. Skibbens, M. Kathryn Iovine   +4 more
wiley   +1 more source

E3 ubiquitin ligase TRIM47 promotes intrahepatic cholangiocarcinoma progression by ubiquitinating fumarate hydratase and modulating macrophage polarization. [PDF]

J Biol Chem
Fu Y, Wu J, Shi J, Jia C.
europepmc   +1 more source