Results 241 to 250 of about 232,343 (304)

Structural basis for E3 ubiquitin ligase UHRF1 binding to nucleosome core particle and histone H3 ubiquitination. [PDF]

J Biol Chem
Shikimachi R, Matsuzawa S, Onoda H, Konuma T, Yamagata A, Shirouzu M, Yamaguchi K, Arita K.   +7 more
europepmc   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Sorafenib promotes the E3 ubiquitin ligase FBXW7 to increase tau degradation and ameliorate tauopathies. [PDF]

Acta Pharm Sin B
Zhou Y, Wang Y, Yang H, Zhang C, Meng J, Zhang L, Li K, Huang LL, Zhang X, Luo H, Zhang Y.   +10 more
europepmc   +1 more source

The tumor necrosis factor receptor superfamily in lung cancer immunotherapy: Therapeutic opportunities and challenges

Precision Medical Sciences, EarlyView.
TNFRSF members orchestrate a dynamic immunoregulatory network in lung cancer by coordinating co‐stimulatory and inhibitory signaling across immune cell populations, highlighting their potential as targets for precision immunotherapy. Abstract Immune checkpoint blockade has fundamentally reshaped the therapeutic landscape of lung cancer.
Bingjie Xue, Liling Dai, Li Dai, Xianglin Zuo   +3 more
wiley   +1 more source

E3 ubiquitin ligase TRIM47 promotes intrahepatic cholangiocarcinoma progression by ubiquitinating fumarate hydratase and modulating macrophage polarization. [PDF]

J Biol Chem
Fu Y, Wu J, Shi J, Jia C.
europepmc   +1 more source

Snapshots of Motion: A Novel Structural Intermediate Reveals Conserved Dynamics in Archaeal DNA Ligases

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We present the first x‐ray crystallographic structural evidence of an archaeal DNA ligase showing the AMP covalent adduct together with further cofactor hydrolysis, capturing a transient intermediary in the first step of the ligation reaction, triggered by the pyrophosphate hydrolysis.
A. X. Quintana‐Armas, E. Flores‐Hernández, C. Cardona‐Félix, E. Rudiño‐Piñera   +3 more
wiley   +1 more source

The E3 ubiquitin ligase STUB1 inhibits Senecavirus A replication by mediating VP1 ubiquitination and proteasomal degradation. [PDF]

J Virol
Zeng P, Mao J, Guo J, Yang X, Shi Y, Wang X, Song J, Zhou J, Hou L, Liu J.   +9 more
europepmc   +1 more source

AlphaFold2‐Guided Cyclic Peptide Stabilizer Design to Target Protein–Protein Interactions

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The control and modulation of protein–protein interactions (PPIs) is of central importance for the majority of biological processes and most biomedical applications. Stabilization of PPIs, besides inhibition, is of growing pharmaceutical interest.
Niklas Halbwedl, Martin Zacharias
wiley   +1 more source

Arylsulfatase B induces melanoma apoptosis by the ubiquitin ligase COP1. [PDF]

J Biol Chem
Bhattacharyya S, O-Sullivan I, Whiteley HE, Yang J, Zhang F, Tobacman JK.   +5 more
europepmc   +1 more source

Structural mechanism for the recognition of E2F1 by the ubiquitin ligase adaptor Cyclin F. [PDF]

Proc Natl Acad Sci U S A
Ngoi P, Wang X, Putta S, Da Luz RF, Serrão VHB, Emanuele MJ, Rubin SM.   +6 more
europepmc   +1 more source