Results 261 to 270 of about 230,401 (303)

Parkin: a multifaceted ubiquitin ligase

Biochemical Society Transactions, 2006
Mutations in the parkin gene are a common cause of autosomal recessive early-onset parkinsonism. Parkin functions as an E3 ubiquitin ligase where it can polyubiquitinate a number of its protein substrates, thus targeting them for degradation by the 26 S proteasomal complex.
openaire   +2 more sources

Monitoring MHC Ubiquitination by MARCH Ubiquitin Ligases

2019
Ubiquitination is a reversible process that controls the intracellular transport of many transmembrane molecules. Ubiquitination of MHC I, MHC II, and CD1a by different members of the MARCH family of E3 ubiquitin ligases is a key event in the regulation of the potent immunostimulatory properties of activated dendritic cells. We describe here methods to
openaire   +2 more sources

Vimentin is a ubiquitination and degradation substrate of the ubiquitin ligase KPC1

Biochemical and Biophysical Research Communications
The ubiquitin proteasome system (UPS), driven by ubiquitin as a degradation signal, eliminates, in a highly specific manner, 'abnormal' proteins and proteins that completed their function. This process involves a hierarchical cascade of E1, E2, and E3 enzymes. The E3 ubiquitin ligases, act as specific receptors that bind their cognate substrates.
Yossi Gottfried, Chen Lulu-Shimron, Gilad Goldhirsh, Yael Fisher, Tamar Ziv, Dave S.B. Hoon, Yelena Kravtsova-Ivantsiv, Aaron Ciechanover   +7 more
openaire   +2 more sources

Lipidating a ubiquitin ligase

Science Signaling, 2019
A previously undescribed enzyme promotes lipidation of a ubiquitin ligase that regulates PI3K and Ca 2+ signaling.
openaire   +1 more source

Systemwide disassembly and assembly of SCF ubiquitin ligase complexes

Cell, 2023
Brenda Schulman, Kheewoong Baek, Daniel Scott   +2 more
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Cullin-RING Ubiquitin Ligase Regulatory Circuits: A Quarter Century Beyond the F-Box Hypothesis

Annual Review of Biochemistry, 2021
Brenda Schulman
exaly  

Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection

Cell Host and Microbe, 2021
Vishva Dixit, Nobuhiko Kayagaki, Joshua Webster   +2 more
exaly  

Wheat RING E3 ubiquitin ligase TaDIS1 degrade TaSTP via the 26S proteasome pathway

Plant Science, 2020
Xuejun Li
exaly  

A Bunyavirus-Inducible Ubiquitin Ligase Targets RNA Polymerase IV for Degradation during Viral Pathogenesis in Rice

Molecular Plant, 2020
Le Xu, Sw Ding, Liang Yang
exaly  

A ubiquitin ligase complex assembles linear polyubiquitin chains

EMBO Journal, 2006
Kazuhiro Iwai, Shigeo Murata, Fuminori Tokunaga   +2 more
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