Results 251 to 260 of about 232,343 (304)

DCAF12 Ubiquitin Ligase Promotes Lung Cancer Metastasis by Modulating the TRiC/CCT Chaperonin Complex. [PDF]

Adv Sci (Weinh)
Wang Z, Huang H, Huang K, Cui X, Wu L, Lin R, Zhao Z, Chen H, Zheng C, Jin W, Chen S, Chen J, Xu Y, Wei D.   +13 more
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Ubiquitin E3 ligase MARCH10 targets influenza hemagglutinin for ubiquitination

Cellular Signalling
Tsai, MuChun, Koch, Dan, Forchione, Anna, Farkas, Laszlo, El-Mergawy, Rabab, Londino, James D., Mallampalli, Rama K.   +6 more
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The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity. [PDF]

FEBS Open Bio
Soeda S, Montrose M, Takahashi A, Ishida R, Burriel S, Ohmine N, Natsume T, Adachi S, Kim M, Yamamoto T.   +9 more
europepmc   +1 more source

The ubiquitin ligase NKLAM promotes apoptosis and suppression of cell growth. [PDF]

J Biol Chem
Willard PA, Kornbluth J.
europepmc   +1 more source

The E3 ubiquitin ligase MARCH9 alleviates pyroptosis by regulating NLPR3 ubiquitination following myocardial ischemia reperfusion. [PDF]

Cell Mol Life Sci
Lu H, Ma G, Ding C, Wang P, Ruan Q, Zeng Y, Ma L, Lu M, Li Y, Sun W.   +9 more
europepmc   +1 more source

Expression of Concern: Rad18 E3 ubiquitin ligase activity mediates Fanconi anemia pathway activation and cell survival following DNA Topoisomerase 1 inhibition. [PDF]

Cell Cycle
europepmc   +1 more source

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E3 ubiquitin ligases

Essays in Biochemistry, 2005
The selectivity of the ubiquitin–26 S proteasome system (UPS) for a particular substrate protein relies on the interaction between a ubiquitin-conjugating enzyme (E2, of which a cell contains relatively few) and a ubiquitin–protein ligase (E3, of which there are possibly hundreds).
Helen C, Ardley, Philip A, Robinson
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A giant ubiquitin ligase

Nature Chemical Biology, 2021
The structure of a giant ubiquitin E3 ligase sheds light on its activation in a substrate-dependent manner and shows how a single E3 enzyme uses distinct recognition modules to confer substrate specificity.
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On ubiquitin ligases and cancer

Human Mutation, 2005
Protein kinase genes account for almost 10% of all currently known cancer genes, highlighting the role of signal transduction in oncogenesis. A reexamination of the literature and available databases shows that E3 ubiquitin ligases are also key mediators of tumorigenesis. Altogether kinase and E3 genes represent more than 15% of the known cancer genes,
Jacques S, Beckmann, Fabienne, Maurer, Mauro, Delorenzi, Laurent, Falquet   +3 more
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E3 ubiquitin ligase Siah1 aggravates NAFLD through Scp2 ubiquitination

International Immunopharmacology, 2023
Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver disorders and accompanied by multiple metabolic dysfunctions. Although excessive lipid accumulation in hepatocytes has been identified as a crucial mediator of NAFLD development, the underlying mechanisms are very complicated and remain largely unknown.
Zhu, Zhu, Xiao, Hu, Kehan, Liu, Jingpei, Li, Kun, Fan, Huafei, Wang, Li, Wang, Lulu, He, Yihui, Ma, Ruijuan, Guan, Zhengyang, Wang   +10 more
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