Results 251 to 260 of about 349,913 (393)

HUWE1 in Skeletal Muscle Prevents Muscle Fatigue via Maintaining Iron and Calcium Homeostasis

open access: yesAdvanced Science, EarlyView.
This study investigates the impact of iron homeostasis on exercise. Loss of the HECT domain‐containing ubiquitin ligase E3 (HUWE1) in skeletal muscle restrains the exercise performance in mice with downregulated ferroportin expression leading to iron overload, which is ameliorated by dietary iron restriction.
Huike Jiao   +10 more
wiley   +1 more source

Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion

open access: yesAdvanced Science, EarlyView.
FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao   +8 more
wiley   +1 more source

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity. [PDF]

open access: yesFEBS Open Bio
Soeda S   +9 more
europepmc   +1 more source

How many E3 ubiquitin ligase are involved in the regulation of nodulation? [PDF]

open access: bronze, 2011
Christine Hervé   +2 more
openalex   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

open access: yesAdvanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li   +14 more
wiley   +1 more source

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