Results 271 to 280 of about 349,913 (393)
Mechanism of Lenvatinib Resistance via Exosomal miRNA‐132/Nrf2 Axis in Hepatocellular Carcinoma
Annals of Gastroenterological Surgery, EarlyView.Exosomal miRNA‐132 from LVT‐res HCC cells activated Nrf2 expression through the PTEN/GSK3β pathway in recipient cells. This cascade could induce drug resistance in non‐resistant HCC cells in the TME. ABSTRACT Introduction Lenvatinib is a multiple receptor tyrosine kinase inhibitor and a first‐line targeted therapy for hepatocellular carcinoma (HCC ...
Chie Takasu +7 more
wiley +1 more source
Emergent Chemical Reactivity and Complexity of RNA Condensates
Angewandte Chemie, EarlyView.RNA condensates capable of substrate enrichment and catalysis modulate their environment. Could this start a catalytic selection loop or evolution? Abstract The RNA world hypothesis posits the existence of life‐like assemblies that consisted mostly of RNA.
Samuel Hauf +4 more
wiley +2 more sources
Genome-wide analysis of the RING-H2 E3 ubiquitin ligase SlATL family in tomato. [PDF]
Sci RepKong X +7 more
europepmc +1 more source
Development of an efficient mice model of cancer‐associated cardiac cachexia
Animal Models and Experimental Medicine, EarlyView.This work establishes a preclinical framework for targeting ubiquitin pathways to mitigate the morbidity of cancer‐related cardiopathy. Our integrated approach delineates a hierarchical progression from subcellular dysfunction to macroscopic cardiac deterioration. These findings mechanistically link tumor‐induced cachexia to cardiac dysfunction through
Shijie Xiong +9 more
wiley +1 more source
Ruthenium Complexes in Protein Science: Heading a New Generation of Therapeutic and Analytical Tools
Angewandte Chemie, EarlyView.This review presents the latest advances in the development of ruthenium complexes within the field of protein science, highlighting their potential applications in biomedical and bioanalytical fields. Abstract Ruthenium complexes are distinguished by their versatile coordination chemistry, redox behaviors and photochemical properties. In recent years,
Liyan Zhang, Yun Chen, Sylvestre Bonnet
wiley +2 more sources
The E3 ubiquitin ligase SPRYD3-MYCBP2(PAM) regulates mitotic cell fate and ubiquitination of USP11 to control spindle assembly. [PDF]
J Biol ChemTuri da Fonte Dias AR, Hoffmann I.
europepmc +1 more source
New approaches to treating chronic obstructive pulmonary disease with Colla corii asini
Animal Models and Experimental Medicine, EarlyView.Colla corii asini improves chronic obstructive pulmonary disease (COPD) treatment through anti‐inflammatory, antioxidant, immune‐modulatory, and lung‐nourishing effects, addressing current therapeutic challenges via multitarget mechanisms. Abstract Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death and disability ...
Wenchao Zhang +5 more
wiley +1 more source
Angewandte Chemie, EarlyView.Tandem protein trans‐splicing (PTS) assembles a protein from three segments. Expanding this technology to individually treat cysteines in each segment, for example, for chemical labeling using thiol bioconjugation, the authors identify a second, highly efficient cysteine‐less split intein.
Christoph Humberg +3 more
wiley +2 more sources