Results 271 to 280 of about 254,188 (362)

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

The ubiquitin ligase NKLAM promotes apoptosis and suppression of cell growth. [PDF]

J Biol Chem
Willard PA, Kornbluth J.
europepmc   +1 more source

E3 ubiquitin ligase BTRC inhibits the proliferation and tumor growth of glioma cells through the NFAT5/AQP4 axis. [PDF]

J Cancer Res Clin Oncol
Li Y, Tang S, Jiang K, Deng P, Hu X.
europepmc   +1 more source

LRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease

Movement Disorders, EarlyView.
Abstract A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...
Anthony E. Lang, Robert A. Hauser, Lorraine V. Kalia, Bonnie Hersh, Zdenek Berger, Roy Llorens Arenas, Coro Paisan‐Ruiz, Kyle Fraser, Danna Jennings, Jillian H. Kluss, Sarah Huntwork‐Rodriguez, Anastasia G. Henry, J. Timothy Greenamyre   +12 more
wiley   +1 more source

Deletion of the E3 ubiquitin ligase LRSAM1 fosters intracellular <i>Staphylococcus aureus</i> survival. [PDF]

Front Cell Infect Microbiol
Plöhn O, Singh AK, Greger C, Wolfgramm H, Baglanova M, Surmann K, Völker U, Bröker BM, Becker K, Seifert U, Cammann C.   +10 more
europepmc   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

The ubiquitin ligase Triad1 influences myeloid leukemogenesis by regulating the integrated stress response. [PDF]

J Biol Chem
Wang H, Suh F, Fischietti M, Wray B, Filip SK, Faull PA, Hu L, Huang W, Liu B, Platanias LC, Eklund EA.   +10 more
europepmc   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Genome-wide analysis of the RING-H2 E3 ubiquitin ligase SlATL family in tomato. [PDF]

Sci Rep
Kong X, Li F, Shang J, Ji Y, Li Y, Hussain S, Zhang X, Ahmed ZFR.   +7 more
europepmc   +1 more source

Role of Zinc in Parkin RING2 E3 Ubiquitin Ligase Ubiquitination

, 2016
KyeongMin Bae
openalex   +1 more source