Results 271 to 280 of about 327,531 (416)

CRISPR/Cas9‐mediated genome editing reveals seven testis‐enriched transmembrane glycoproteins dispensable for male fertility in mice

Andrology, EarlyView., 2023
Abstract Background Mammalian fertilization is mediated by multiple sperm acrosomal proteins, many of which are testis‐enriched transmembrane glycoproteins expressed during spermiogenesis (e.g., Izumo sperm‐egg fusion 1, Sperm acrosome associated 6, and Transmembrane protein 95).
Yo Ogawa, Yonggang Lu, Daiji Kiyozumi, Hsin‐Yi Chang, Masahito Ikawa   +4 more
wiley   +1 more source

The Cul3 Ubiquitin Ligase: An Essential Regulator of Diverse Cellular Processes

, 2000
Brittney Davidge
openalex   +2 more sources

Ubiquitin and the SCF^Grr1 ubiquitin ligase complex are involved in the signalling pathway activated by external amino acids in Saccharomyces cerevisiae [PDF]

, 2001
Florent Bernard, Bruno André
openalex   +1 more source

The RNA Binding Protein Bcas2 is Required for Antibody Class Switch in Activated‐B Cells

Exploration, EarlyView.
Bcas2 recruits DHX15 and SRSF7 to form a protein complex for the splicing of CSR‐related mRNA at the 5' ss and 3' ss, generating two mature mRNA isoforms, which are ultimately translated into CSR‐related proteins. These CSR‐related proteins bind to DNA associated with antibodies, affecting the DSB repair of the relevant DNA after AID induction, thereby
Yu Chen, Siyuan Sun, Chenxu Lu, Yixuan Li, Bing Fang, Xiangfeng Tang, Xuepeng Li, Weiru Yu, Yumei Lei, Longjie Sun, Ming Zhang, Jiazeng Sun, Ping Liu, Yongting Luo, Xingwang Zhao, Jing Zhan, Libing Liu, Rong Liu, Jiaqiang Huang, Ziwei Yi, Yifei Yu, Weihan Xiao, Zheng Ding, Lei Li, Dan Su, Fazheng Ren, Changchang Cao, Ran Wang, Wenbiao Shi, Juan Chen   +29 more
wiley   +1 more source

E3 Siah ubiquitin ligase regulates dichotomous spermatogenesis in Sitotroga cerealella. [PDF]

Front Cell Dev Biol
Shah S, Shi CM, Elgizawy KK, Yan WH, Wu G, Wang XP, Yang FL.   +6 more
europepmc   +1 more source

FYVE Domain Targets Pib1p Ubiquitin Ligase to Endosome and Vacuolar Membranes [PDF]

, 2001
Marcus E. Shin, Kenyon D. Ogburn, Oliver A. Varban, Penney M. Gilbert, Christopher G. Burd   +4 more
openalex   +1 more source

The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro. [PDF]

Life Sci Alliance
Wang XS, Jiou J, Cerra A, Cobbold SA, Jochem M, Mak KHT, Corcilius L, Silke J, Payne RJ, Goddard-Borger ED, Komander D, Lechtenberg BC.   +11 more
europepmc   +1 more source

Kinetic Analysis of the Conjugation of Ubiquitin to Picornavirus 3C Proteases Catalyzed by the Mammalian Ubiquitin-protein Ligase E3α [PDF]

, 2001
T. Glen Lawson, Molly E. Sweep, Peter E. Schlax, Richard N. Bohnsack, Arthur L. Haas   +4 more
openalex   +1 more source

The inhibition of MDM2 slows cell proliferation and activates apoptosis in ADPKD cell lines

Biology of the Cell, Volume 115, Issue 1, January 2023., 2023
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a pathology characterised by the formation of kidney cists that impair renal function. The wall of renal cysts is covered with cystic cells that show increased activation of mTOR. Abnormal mTOR activation inhibits autophagy, promotes the degradation of TP53 by the proteasome in a mechanism ...
Simone Patergnani, Antonino Giattino, Nicoletta Bianchi, Carlotta Giorgi, Paolo Pinton, Gianluca Aguiari   +5 more
wiley   +1 more source

E3 ubiquitin ligase HECW2: a promising target for tumour therapy. [PDF]

Cancer Cell Int
Shen H, Kou Q, Shao L, Zhang J, Li F.
europepmc   +1 more source