Results 281 to 290 of about 349,913 (393)

The E3 ubiquitin ligase TRIM56 promotes aggregation and activation of Src protein through Lys63-linked polyubiquitination in hepatocellular carcinoma. [PDF]

Cell Death Dis
Zhu L, Cui X, Xu H, Yang M, Han L.
europepmc   +1 more source

Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu, Zhiyang Zeng, Xinyu Ming, Shuming Yin, Yuting Guan, Liangcai Gao, Dali Li   +6 more
wiley   +1 more source

Design, Synthesis, and Structural Evolution of Pseudo‐Natural Product IDO1 Inhibitors and Degraders

Angewandte Chemie, EarlyView.
The combination of bicyclic monoterpene‐ and pyrrolidine‐alkaloid fragments yields novel pseudo‐natural products. Biological characterization revealed that these iDegs are inhibitors and degraders of indoleamine‐2,3‐dioxygenase. Abstract Terpenoid alkaloids are derived from the fusion of structurally diverse terpenoid‐ and alkaloid moieties.
Xiu‐Fen Cheng, Belén Lucas, Philipp Lampe, Stefano Ugel, Suyuan Chen, Anke Unger, Matthias Bischoff, Soheila Rezaei Adariani, Kesava Reddy Naredla, Kamal Kumar, Annika Schmidt, Carsten Strohmann, Petra Janning, Raphael Gasper, María Lucas, Malte Gersch, Sonja Sievers, Vincenzo Bronte, Slava Ziegler, Herbert Waldmann   +19 more
wiley   +2 more sources

“Design principles of a membrane-spanning ubiquitin ligase”

Williams C, Nocka LM, Hedger G, Parashara P, Pardon E, Latorraca NR, Pusapati GV, Lartey D, Gao L, Milenkovic L, Chalk R, Steyaert J, Marqusee S, Carrique L, Bazan JF, Rouse SL, Kong JH, Siebold C, Rohatgi R.   +18 more
europepmc   +1 more source

A genetic screen identifies the E3 ubiquitin ligase MPSR1 as a suppressor of early flowering of the sensitivity to red light reduced 1 mutant. [PDF]

Sci Rep
Johansson M, Liu W, Steffen A, Vanderwall M, Gendron JM, Staiger D.   +5 more
europepmc   +1 more source

The ubiquitin ligase Nedd4-2 promotes localization of DNMBP/Tuba to P-bodies under hyperosmotic stress. [PDF]

J Biol Chem
Liu Z, Jiang C, Yeung F, Raught B, Rotin D.   +4 more
europepmc   +1 more source

LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundance

Ramage DE, Wieske LH, Crowe C, Christensen JB, von Wilmowski TA, Grant DW, Bannister Z, Nakasone MA, Haubrich K, Dorward M, Tchasovnikarova IA, Weekes MP, Bayin NS, Ciulli A, Timms RT.   +14 more
europepmc   +1 more source

Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.

Cancer Cell, 2014
Ryan J. Davis, M. Welcker, B. Clurman
semanticscholar   +1 more source

ETV4 promotes ovarian cancer growth by regulating mitochondrial function through Mfn2 ubiquitination mediated by the E3 ubiquitin ligase MARCH9. [PDF]

Cell Biol Toxicol
Wang Y, Wang Z, Chen J, Cai L, Luo X, Wu N.   +5 more
europepmc   +1 more source

The Brain Proteome of the Ubiquitin Ligase Peli1 Knock-Out Mouse during Experimental Autoimmune Encephalomyelitis

, 2016
Ragnhild Reehorst Lereim, Eystein Oveland, Yichuan Xiao, Øivind Torkildsen, Stig Wergeland, Kjell-Morten Myhr, Shao‐Cong Sun, Frode S. Berven   +7 more
openalex   +1 more source