Results 21 to 30 of about 248,165 (360)
The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation
Science, 2020 Turning the tables on microRNA decay MicroRNAs help to regulate many genes in animal cells. Each microRNA associates with an Argonaute (AGO) protein, forming a complex in which the microRNA pairs with a messenger RNA (mRNA) target and AGO recruits ...
Charlie Y. Shi +5 more
semanticscholar +1 more source
The EHEC type III effector NleL is an E3 ubiquitin ligase that modulates pedestal formation. [PDF]
PLoS ONE, 2011 Enterohemorrhagic Escherichia coli (EHEC) O157:H7 causes hemorrhagic colitis and may result in potentially fatal hemolytic uremia syndrome in humans. EHEC colonize the intestinal mucosa and promote the formation of actin-rich pedestals via translocated ...
Heather Piscatelli +7 more
doaj +1 more source
A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming
Science, 2020 Turning the tables on microRNA decay MicroRNAs help to regulate many genes in animal cells. Each microRNA associates with an Argonaute (AGO) protein, forming a complex in which the microRNA pairs with a messenger RNA (mRNA) target and AGO recruits ...
Jaeil Han +5 more
semanticscholar +1 more source
Ubiquitin ligase activity inhibits Cdk5 to control axon termination.
PLoS Genetics, 2022 The Cdk5 kinase plays prominent roles in nervous system development, plasticity, behavior and disease. It also has important, non-neuronal functions in cancer, the immune system and insulin secretion.
Muriel Desbois +5 more
doaj +1 more source
Plants, 2023 Plant U-box E3 ubiquitin ligases (PUBs) play an important role in growth, development, and stress responses in many species. However, the characteristics of U-box E3 ubiquitin ligase genes in cabbage (Brassica oleracea var.
Peiwen Wang +7 more
doaj +1 more source
A Ubiquitin-like Protein Unleashes Ubiquitin Ligases [PDF]
Cell, 2008 Modification of cullin-RING ubiquitin ligases by the ubiquitin-like molecule Nedd8 promotes substrate ubiquitination. A crystal structure of a cullin modified by Nedd8 recently reported in Cell (Duda et al., 2008) and a biochemical study in Molecular Cell (Saha and Deshaies, 2008) reveal the dramatic impact on the ligase machinery by conjugation of ...
Ning Zheng +2 more
openaire +3 more sources
Role of Nse1 Subunit of SMC5/6 Complex as a Ubiquitin Ligase
Cells, 2022 Structural Maintenance of Chromosomes (SMC) complexes are important for many aspects of the chromosomal organization. Unlike cohesin and condensin, the SMC5/6 complex contains a variant RING domain carried by its Nse1 subunit.
Peter Kolesar +4 more
doaj +1 more source
G3BP1 modulates SPOP to promote prostate tumorigenesis
Molecular & Cellular Oncology, 2022 Speckle-type POZ protein (SPOP), a Cullin 3-based ubiquitin ligase (CUL3SPOP), acts as a prostate-specific tumor suppressor. Loss-of-function mutations in SPOP occur in 10% of primary prostate cancer with a high Gleason grade and poor prognosis. However,
Chandrani Mukhopadhyay, Pengbo Zhou
doaj +1 more source
The SCF Ubiquitin Ligase [PDF]
Molecular Cell, 2002 The SCF E3 ubiquitin ligases select specific proteins for ubiquitination (and typically destruction) by coupling variable adaptor (F box) proteins that bind protein substrates to a conserved catalytic engine containing a cullin, Cul1, and the Rbx1/Roc1 RING finger protein.
Adam G. Eldridge, Peter K. Jackson
openaire +3 more sources
Trim25 restricts rabies virus replication by destabilizing phosphoprotein
Cell Insight, 2022 Tripartite motif-containing protein 25 (Trim25) is an E3 ubiquitin ligase that activates retinoid acid-inducible gene I (RIG-I) and promotes the antiviral interferon response.
Yueming Yuan +11 more
doaj +1 more source