Results 41 to 50 of about 254,188 (362)

The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response

PLoS Pathogens, 2017
The cyclic GMP-AMP synthase (cGAS), upon cytosolic DNA stimulation, catalyzes the formation of the second messenger 2′3′-cGAMP, which then binds to stimulator of interferon genes (STING) and activates downstream signaling. It remains to be elucidated how
Qiang Wang, Liyuan Huang, Ze Hong, Zhongshi Lv, Zhaomin Mao, Yijun Tang, X. Kong, Senlin Li, Ye Cui, Heng Liu, Lele Zhang, Xiaojie Zhang, Lindi Jiang, Chen Wang, Qin Zhou   +14 more
semanticscholar   +1 more source

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Nature Communications, 2017
E3 ubiquitin ligases are key enzymes within the ubiquitin proteasome system which catalyze the ubiquitination of proteins, targeting them for proteasomal degradation.
Chiara Maniaci, S. Hughes, Andrea Testa, Wenzhang Chen, D. Lamont, S. Rocha, D. Alessi, R. Romeo, A. Ciulli   +8 more
semanticscholar   +1 more source

Identification of a MicroRNA‐E3 Ubiquitin Ligase Regulatory Network for Hepatocyte Death in Alcohol‐Associated Hepatitis

Hepatology Communications, 2021
We aimed to identify a microRNA (miRNA)‐E3 ubiquitin ligase regulatory network for protein substrates enriched in cell death pathways and investigate the underlying molecular mechanisms in alcohol‐associated hepatitis (AH).
Xiude Fan, Jianguo Wu, Kyle L. Poulsen, Adam Kim, Xiaoqin Wu, Emily Huang, Tatsunori Miyata, Carlos Sanz‐Garcia, Laura E. Nagy   +8 more
doaj   +1 more source

RMND5 from Xenopus laevis is an E3 ubiquitin-ligase and functions in early embryonic forebrain development. [PDF]

PLoS ONE, 2015
In Saccharomyces cerevisiae the Gid-complex functions as an ubiquitin-ligase complex that regulates the metabolic switch between glycolysis and gluconeogenesis.
Thorsten Pfirrmann, Pablo Villavicencio-Lorini, Abinash K Subudhi, Ruth Menssen, Dieter H Wolf, Thomas Hollemann   +5 more
doaj   +1 more source

The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3

Nature Communications, 2016
The NLRP3 inflammasome has a fundamental role in host defence against microbial pathogens and its deregulation may cause diverse inflammatory diseases. NLRP3 protein expression is a rate-limiting step for inflammasome activation, thus its expression must
Hui Song, Bingyu Liu, Wanwan Huai, Zhongxia Yu, Wenwen Wang, Jing Zhao, Lihui Han, G. Jiang, Lining Zhang, Chengjiang Gao, Wei Zhao   +10 more
semanticscholar   +1 more source

Identification of E3 Ubiquitin Ligase Substrates Using Biotin Ligase-Based Proximity Labeling Approaches

Biomedicines
Ubiquitylation is a post-translational modification originally identified as the first step in protein degradation by the ubiquitin–proteasome system. Ubiquitylation is also known to regulate many cellular processes without degrading the ubiquitylated ...
Koji Matsuhisa, Shinya Sato, Masayuki Kaneko   +2 more
doaj   +1 more source

TRIM56 coiled-coil domain structure provides insights into its E3 ligase functions

Computational and Structural Biotechnology Journal, 2023
Protein ubiquitination is a post-translation modification mediated by E3 ubiquitin ligases. The RING domain E3 ligases are the largest family of E3 ubiquitin ligases, they act as a scaffold, bringing the E2-ubiquitin complex and its substrate together to
Xiaohua Lou, Binbin Ma, Yuan Zhuang, Xiang Xiao, Laurie J. Minze, Junji Xing, Zhiqiang Zhang, Xian C. Li   +7 more
doaj   +1 more source

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

Journal of Cell Biology, 2014
PINK1 phosphorylates ubiquitin, which then binds to Parkin and activates its E3 ligase activity, leading to induction of selective autophagy of damaged mitochondria.
L. A. Kane, M. Lazarou, A. I. Fogel, Yan Li, Koji Yamano, Shireen A. Sarraf, Soojay Banerjee, R. Youle   +7 more
semanticscholar   +1 more source

A Key Role for the Ubiquitin Ligase UBR4 in Myofiber Hypertrophy in Drosophila and Mice

Cell Reports, 2019
Summary: Skeletal muscle cell (myofiber) atrophy is a detrimental component of aging and cancer that primarily results from muscle protein degradation via the proteasome and ubiquitin ligases.
Liam C. Hunt, Jared Stover, Benard Haugen, Timothy I. Shaw, Yuxin Li, Vishwajeeth R. Pagala, David Finkelstein, Elisabeth R. Barton, Yiping Fan, Myriam Labelle, Junmin Peng, Fabio Demontis   +11 more
doaj   +1 more source

RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation

Cell Reports, 2018
Summary: X-linked intellectual disability (XLID) is a heterogeneous syndrome affecting mainly males. Human genetics has identified >100 XLID genes, although the molecular and developmental mechanisms underpinning this disorder remain unclear.
Francisco Bustos, Anna Segarra-Fas, Viduth K. Chaugule, Lennart Brandenburg, Emma Branigan, Rachel Toth, Thomas Macartney, Axel Knebel, Ronald T. Hay, Helen Walden, Greg M. Findlay   +10 more
doaj   +1 more source