Results 61 to 70 of about 133,567 (215)
RNF122: A novel ubiquitin ligase associated with calcium-modulating cyclophilin ligand
BMC Cell Biology, 2010 Background RNF122 is a recently discovered RING finger protein that is associated with HEK293T cell viability and is overexpressed in anaplastic thyroid cancer cells.
Shi Taiping, Peng Zhi, Ma Dalong
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PLoS Pathogens, 2020 The HECT domain E3 ubiquitin ligase E6AP (UBE3A) is critical for the development of human papillomavirus (HPV) associated cancers, the neurodevelopment disorder Angelman Syndrome, and some cases of autism spectrum disorders.
Camille M Drews +2 more
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RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
Nature Communications, 2017 Ubiquitin ligases play critical roles in neuronal connectivity in the brain. Here, Valnegri and colleagues show that ubiquitin ligase RNF8 and ubiquitin-conjugating enzyme UBC13 regulate synapse number in cerebellar granule neurons and rodent cerebellar ...
Pamela Valnegri +7 more
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A Key Role for the Ubiquitin Ligase UBR4 in Myofiber Hypertrophy in Drosophila and Mice
Cell Reports, 2019 Summary: Skeletal muscle cell (myofiber) atrophy is a detrimental component of aging and cancer that primarily results from muscle protein degradation via the proteasome and ubiquitin ligases.
Liam C. Hunt +11 more
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Origin and Diversification of TRIM Ubiquitin Ligases
PLoS ONE, 2012 Most proteins of the TRIM family (also known as RBCC family) are ubiquitin ligases that share a peculiar protein structure, characterized by including an N-terminal RING finger domain closely followed by one or two B-boxes. Additional protein domains found at their C termini have been used to classify TRIM proteins into classes.
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The role of ubiquitin ligases in cardiac disease
Journal of Molecular and Cellular Cardiology, 2014 Rigorous surveillance of protein quality control is essential for the maintenance of normal cardiac function, while the dysregulation of protein turnover is present in a diverse array of common cardiac diseases. Central to the protein quality control found in all cells is the ubiquitin proteasome system (UPS).
Cam Patterson +5 more
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Cell Reports, 2018 Summary: X-linked intellectual disability (XLID) is a heterogeneous syndrome affecting mainly males. Human genetics has identified >100 XLID genes, although the molecular and developmental mechanisms underpinning this disorder remain unclear.
Francisco Bustos +10 more
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TRIM56 coiled-coil domain structure provides insights into its E3 ligase functions
Computational and Structural Biotechnology Journal, 2023 Protein ubiquitination is a post-translation modification mediated by E3 ubiquitin ligases. The RING domain E3 ligases are the largest family of E3 ubiquitin ligases, they act as a scaffold, bringing the E2-ubiquitin complex and its substrate together to
Xiaohua Lou +7 more
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Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle [PDF]
, 1999 Ellen Freed +6 more
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A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. [PDF]
, 1995 J M Huibregtse +3 more
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