Does inter-organellar proteostasis impact yeast quality and performance during beer fermentation? [PDF]
, 2019 During beer production, yeast generate ethanol that is exported to the extracellular environment where it accumulates. Depending on the initial carbohydrate concentration in the wort a high concentration of ethanol can be achieved in beer, often higher than 20% (v/v). It is noteworthy that the effects of elevated ethanol concentrations generated during
arxiv +1 more source
The rna-binding ubiquitin ligase mex3a affects glioblastoma tumorigenesis by inducing ubiquitylation and degradation of rig-i [PDF]
, 2020 Glioblastoma multiforme (GB) is the most malignant primary brain tumor in humans, with an overall survival of approximatively 15 months. The molecular heterogeneity of GB, as well as its rapid progression, invasiveness and the occurrence of drug ...
Basili, I. +12 more
core +1 more source
The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains
eLife, 2021 The linear ubiquitin chain assembly complex (LUBAC) is the only known ubiquitin ligase for linear/Met1-linked ubiquitin chain formation. One of the LUBAC components, heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1L), was recently shown to catalyse oxyester
Alan Rodriguez Carvajal +14 more
doaj +1 more source
TRIM32 is an E3 ubiquitin ligase for dysbindin [PDF]
Human Molecular Genetics, 2009 Mutations in the gene encoding tripartite motif protein 32 (TRIM32) cause two seemingly diverse diseases: limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11(BBS11). Although TRIM32 is involved in protein ubiquitination, its substrates and the molecular consequences of disease-causing ...
Matthew Locke +3 more
openaire +4 more sources
Phosphorylation of Arabidopsis SINA2 by CDKG1 affects its ubiquitin ligase activity
BMC Plant Biology, 2018 Background SEVEN IN ABSENTIA (SINA) is a RING domain-containing ubiquitin ligase involved in Drosophila eye formation. SINA-like proteins in plants are involved in several signaling pathways.
Yang Chen +5 more
doaj +1 more source
A ubiquitin-specific, proximity-based labeling approach for the identification of ubiquitin ligase substrates [PDF]
Over 600 E3 ligases in humans execute ubiquitination of specific target proteins in a spatiotemporal manner to elicit desired signaling effects. Here, we developed a ubiquitin-specific proximity-based labeling method to selectively biotinylate substrates
Behrends, Christian +6 more
core +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Trim25 restricts rabies virus replication by destabilizing phosphoprotein
Cell Insight, 2022 Tripartite motif-containing protein 25 (Trim25) is an E3 ubiquitin ligase that activates retinoid acid-inducible gene I (RIG-I) and promotes the antiviral interferon response.
Yueming Yuan +11 more
doaj
E3-ubiquitin ligases and recent progress in osteoimmunology
Frontiers in Immunology, 2023 Ubiquitin-mediated proteasomal degradation is a post-transcriptional protein modification that is comprised of various components including the 76-amino acid protein ubiquitin (Ub), Ub-activating enzyme (E1), Ub-conjugating enzyme (E2), ubiquitin ligase (
Yosuke Asano +8 more
doaj +1 more source
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
Journal of Cell Biology, 2014 PINK1 phosphorylates ubiquitin, which then binds to Parkin and activates its E3 ligase activity, leading to induction of selective autophagy of damaged mitochondria.
L. A. Kane +7 more
semanticscholar +1 more source