SCFbeta-TrCP ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase [PDF]
, 2000 Amir Orian +9 more
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Regulation of the cardiac voltage‐gated Na+ channel (H1) by the ubiquitin‐protein ligase Nedd4 [PDF]
, 2000 Hugues Abriel +3 more
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NEDD4 family E3 ligases in osteoporosis: mechanisms and emerging potential therapeutic targets
Journal of Orthopaedic Surgery and ResearchOsteoporosis is a systemic skeletal disorder characterized by reduced bone density and an increased risk of fractures, particularly prevalent in the aging population.
Heng Wu +4 more
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A putative ubiquitin ligase required for efficient mRNA export differentially affects hnRNP transport [PDF]
, 2000 Kent E. Duncan +2 more
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Cullin-RING Ubiquitin Ligases in Neurodevelopment and Neurodevelopmental Disorders
BiomedicinesUbiquitination is a dynamic and tightly regulated post-translational modification essential for modulating protein stability, trafficking, and function to preserve cellular homeostasis.
Honoka Ashitomi +3 more
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Quantitative expression analysis of the cellular specificity of HECT-domain ubiquitin E3 ligases [PDF]
, 2000 Liliana E. Scarafia +2 more
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A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling
Cell Reports, 2018 Summary: Ubiquitination is essential for protein degradation and signaling and pivotal to many physiological processes. Ubiquitination of a subset of G-protein-coupled receptors (GPCRs) by the E3 ligase NEDD4-2 is required for p38 activation, but how ...
Neil J. Grimsey +10 more
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The DSmurf Ubiquitin-Protein Ligase Restricts BMP Signaling Spatially and Temporally during Drosophila Embryogenesis [PDF]
, 2001 Steven D. Podos +3 more
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