Results 81 to 90 of about 327,531 (416)
Molecular Oncology, EarlyView.The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh +6 more
wiley +1 more source
CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory. [PDF]
PLoS Genetics, 2018 Intellectual disability (ID), one of the most common human developmental disorders, can be caused by genetic mutations in Cullin 4B (Cul4B) and cereblon (CRBN).
Tianyu Song +12 more
doaj +1 more source
A Generic Platform for Cellular Screening Against Ubiquitin Ligases [PDF]
, 2016 Ubiquitin signalling regulates most aspects of cellular life, thus deregulation of ubiquitylation has been linked with a number of diseases. E3 ubiquitin ligases provide substrate selectivity in ubiquitylation cascades and are therefore considered to be ...
AD Capili +31 more
core +2 more sources
Molecular Biology of the Cell, 2016 A new posttranslational modification is found of centromeric histone H3 variant Cse4. Cse4 is sumoylated by E3 ligases Siz1 and Siz2 and ubiquitinated by Slx5, a Sumo-targeted ubiquitin ligase.
Kentaro Ohkuni +12 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
MG53/TRIM72: multi-organ repair protein and beyond
Frontiers in PhysiologyMG53, a member of the tripartite motif protein family, possesses multiple functionalities due to its classic membrane repair function, anti-inflammatory ability, and E3 ubiquitin ligase properties.
Yong-Fei Wang +9 more
doaj +1 more source
Nature Communications, 2023 Pathogen-associated molecular patterns (PAMPs) trigger plant innate immunity that acts as the first line of inducible defense against pathogen infection.
Jiaojiao Bai +8 more
doaj +1 more source
Nature Structural &Molecular Biology, 2017 RING-between-RING (RBR) E3 ligases are a class of ubiquitin ligases distinct from RING or HECT E3 ligases. An important RBR ligase is Parkin, mutations in which lead to early-onset hereditary Parkinsonism.
Atul Kumar +9 more
semanticscholar +1 more source
Control of the SCFSkp2–Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase
Nature, 2004 Skp2 and its cofactor Cks1 are the substrate-targeting subunits of the SCF(Skp2-Cks1) (Skp1/Cul1/F-box protein) ubiquitin ligase complex that regulates entry into S phase by inducing the degradation of the cyclin-dependent kinase inhibitors p21 and p27 (ref. 1). Skp2 is an oncoprotein that often shows increased expression in human cancers; however, the
Bashir, Tarig +4 more
openaire +3 more sources
AIRE Functions As an E3 Ubiquitin Ligase [PDF]
The Journal of Experimental Medicine, 2004 Autoimmune regulator (AIRE) gene mutation is responsible for the development of autoimmune-polyendocrinopathy-candidiasis ectodermal dystrophy, an organ-specific autoimmune disease with monogenic autosomal recessive inheritance. AIRE is predominantly expressed in medullary epithelial cells of the thymus and is considered to play important roles in the ...
Nobuyoshi Shimizu +11 more
openaire +3 more sources