Results 161 to 170 of about 274,920 (356)

Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex‐dependent regulation of glycolysis

, 2021
Matthew E. R. Maitland, Miljan Kuljanin, Xu Wang, Gilles Lajoie, Caroline Schild‐Poulter   +4 more
openalex   +2 more sources

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology
Transcription factors, pivotal in gene expression regulation, are essential in cancer progression. Their function is meticulously regulated by post‐translational modifications, including ubiquitination. This process, which marks proteins for degradation,
Dongha Kim, Hye Jin Nam, Sung Hee Baek
doaj   +1 more source

β2-Adrenergic Receptor Lysosomal Trafficking Is Regulated by Ubiquitination of Lysyl Residues in Two Distinct Receptor Domains

, 2011
Kunhong Xiao, Sudha K. Shenoy
openalex   +1 more source

Ubiquitin, ubiquitination and the ubiquitin-proteasome system in cancer [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
openaire   +1 more source

Promoter Hypermethylation‐Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5‐Mediated Wnt/β‐Catenin Pathway Activation

Advanced Science, EarlyView.
This study identifies FXYD1 as an epigenetically silenced tumor suppressor in breast cancer. DNA methylation turns off the gene FXYD1 in breast cancer, and low levels predict worse outcomes. Restoring FXYD1 limits breast cancer cells proliferation and metastasis. In the nucleus, FXYD1 recruits the E3 ligase MAEA to K63‐ubiquitinate DDX5 for proteasomal
Ping Wen, Fanli Qu, Long Wang, Qing Shao, Sisi Li, Yang Qin, Dongping Jiang, Senmiao Zhang, Jiangdong Sui, Guanwen Wang, Ningning Zhang, Xiaohua Zeng   +11 more
wiley   +1 more source

Identification and validation of USP15 and CUL2 as ubiquitination related biomarker in chronic obstructive pulmonary disease

Hereditas
Purpose Ubiquitination is one of the important epigenetic modifications, influencing the development of various diseases. The objective of this study is to investigate the ubiquitination related genes in chronic obstructive pulmonary disease (COPD ...
Shulei Sun, Zhaoxiong Zhang, Haiyan Zhao
doaj   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

Additional file 2 of Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG

, 2020
Sofía Espinoza, Sebastián B. Arredondo, Francisca Barake, Francisco J. Carvajal, Fernanda G. Guerrero, Fabián Segovia‐Miranda, David M. Valenzuela, Úrsula Wyneken, Alejandro Rojas‐Fernández, Waldo Cerpa, Loreto Massardo, Lorena Varela‐Nallar, Alfonso González   +12 more
openalex   +1 more source

m5C‐Modified tRF3b‐CysGCA‐23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4

Advanced Science, EarlyView.
In this study, we identified an NSUN6‐dependent m5C‐modified tsRNA, m5C‐tRF3b CysGCA‐23 (mtRC), that is downregulated in BC and inversely correlated with disease progression. Mechanistically, mtRC suppresses BC malignancy by stabilizing RBM4, attenuating glycolysis, and thereby limiting H3K18 lactylation–mediated activation of IL1RAP and VASH2 ...
Xiaoling Ying, Yapeng Huang, Jian Huang, Qinyu Cai, Danni Zhang, Cong Chen, Yuxi Nie, Baotong Yang, Chuan Li, Wenyu Hu, Chang Xiong, Chengcheng Zhang, Ding Ji, Yaomin Liang, Mei Yang, Wenqi Wu, Weidong Ji   +16 more
wiley   +1 more source

Ubiquitination and ALL: Identifying FBXO8 as a prognostic biomarker and therapeutic target [PDF]

Wei Xian, Yinting Chen, Shuiqing Yu, Zhitao Ye, Yu Zhang, Danlin Yao   +5 more
openalex   +1 more source