Results 241 to 250 of about 308,731 (375)

TOGR3, a Proteasome β4 Subunit, Orchestrates Sugar Homeostasis to Trade Off Growth and Thermotolerance in Rice

Advanced Science, EarlyView.
This study identifies a novel thermoregulatory mechanism in rice: TOGR3 partners with 26S proteasome subunits, including TT1, to drive thermoresponsive ubiquitin–proteasome activity, maintaining sugar homeostasis in stomatal regulation to balance growth and stress resistance.
Biyao Zhang, Xiaoyan Wu, Ting Xu, Feifei Guo, Xiaolu Shen, Cuiping Meng, Yanan Wang, Xue Han, Hong Zhao, Yongbiao Xue   +9 more
wiley   +1 more source

NEDD4 promotes reactive astrogliosis by enhancing K63-linked ubiquitination and inhibiting chaperone-mediated autophagy degradation of YAP1. [PDF]

Int J Biol Sci
Ye W, Li Y, Wang W, Pan D, Wang X, Gu Y, Zhu Y, Wang H, Lu X, Jiang D, Tang P, Shu H, Ma J, Cai W.   +13 more
europepmc   +1 more source

ATF7IP regulates SETDB1 nuclear localization and increases its ubiquitination [PDF]

, 2019
Takeshi Tsusaka, Chikako Shimura, Yoichi Shinkai   +2 more
openalex   +1 more source

Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

Advanced Science, EarlyView.
The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li, Chang Liu, Zhaoxue Ma, Dongyou Zheng, Renkai Wang, Yongjing Yu, Guangmin Chen, Chenglong Li, Yue Bu, Hang Cao, Bing Zhang   +10 more
wiley   +1 more source

Exploring the ubiquitination regulatory network: opening new perspectives for rheumatoid arthritis therapy. [PDF]

Ann Med
Wang F, Liu J, Wen J, Sun Y, He M.
europepmc   +1 more source

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, EarlyView.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

Novel ubiquitination-related biomarkers for Crohn's disease identified by multi-omics study and experimental validation. [PDF]

Front Immunol
Hu J, Nie K, Wang X.
europepmc   +1 more source

Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation

Proceedings of the National Academy of Sciences of the United States of America, 2001
K. Sakamoto, K. Kim, A. Kumagai, F. Mercurio, C. Crews, R. Deshaies   +5 more
semanticscholar   +1 more source

PUGNAc induces protein ubiquitination in C2C12 myotube cells [PDF]

, 2015
Ja-Hye Park, Jeong‐Eun Lee, Pyong‐Gon Moon, Moon‐Chang Baek   +3 more
openalex   +1 more source

Regulation of oxidative stress-induced autophagy by ATG9A ubiquitination

, 2022
Yi-Ting Wang, Guang‐Chao Chen
openalex   +2 more sources