Results 291 to 300 of about 308,731 (375)

Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response. [PDF]

Elife
Lu LF, Zhang C, Li ZC, Cui BJ, Wang YY, Han KJ, Xu X, Zhou CJ, Zhou XY, Wu Y, Xu N, Yang XL, Chen DD, Li X, Zhou L, Li S.   +15 more
europepmc   +1 more source

Proteome solubility is differentially reshaped by thermal stress and regulators of ubiquitination [PDF]

Liam C. Hunt, Anna Stephan, Suresh Poudel, Kaiwen Yu, Kanisha Kavdia, Vishwajeeth Pagala, Wei Wang, Yingxue Fu, Yong‐Dong Wang, Xusheng Wang, Flávia A. Graça, Deborah Alford, John M. A. Grime, Anthony A. High, Junmin Peng, Fabio Demontis   +15 more
openalex   +1 more source

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

Advanced Science, EarlyView.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang, Shipeng Dai, Yuchen Xie, Pengyu Chen, Yue Chai, Chongyu Wang, Xueying Huang, Xiao Dong, Junfeng Shi, Yongxiang Xia, Xiaofeng Qian, Weiwei Tang, Yichan Zhou   +12 more
wiley   +1 more source

The deubiquitinating enzyme Cezanne stabilizes BRCA1 by counteracting APC/C and Ube2S-dependent Lys11-linked ubiquitination. [PDF]

PLoS Biol
Wang L, Wu X, Paul A, Yao J, Wang B.
europepmc   +1 more source

Traceless Regulation of Genetic Circuitry

Advanced Science, EarlyView.
Energy‐based, as opposed to molecular, control offers unprecedented improvements in key circuit parameters. This review summarizes the fundamentals of such traceless switches, categorizes them by trigger modalities, and compares and contrasts distinct advantages as well as shortcomings of each kind.
Gokberk Unal, Martin Fussenegger
wiley   +1 more source

UBE2V1 Promotes Hepatocellular Carcinoma Progression by Forming a Positive Feedback Loop with HIF-1α. [PDF]

Research (Wash D C)
Yuan Z, Hu S, Zhu Q, Fang Y, Liu X, Li S, Hu X, Tu K, Xu Q, Huang D, Cui D.   +10 more
europepmc   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

The G9a-TRIM21 axis exacerbates diabetic renal ischemia-reperfusion injury by inducing methylation-dependent ubiquitination and degradation of FoxO3a to promote oxidative stress and pyroptosis. [PDF]

Redox Biol
Zheng Q, Qin X, Huang S, Yan Z, Liu J, Xiong Y, Zhao X, Ni X, Mei H, Jian J, Wang J, Lu Q, Chen Z, Liu X, Wan S, Liu H, Wang L.   +16 more
europepmc   +1 more source

Bioorthogonal Sonodynamic Plug‐and‐Play Targeting Chimeras (SDPTAC) for Precise Targeted Protein Degradation

Advanced Science, EarlyView.
Bioorthogonal SDPTAC harnesses US‐responsive Ce6‐TCO and Tz ligands via IEDDA click chemistry to assemble degraders in situ, generating ROS that selectively eliminate nuclear, cytosolic, and membrane proteins, thereby suppressing deep‐seated tumors in vivo.
Yuhan Bao, Yaojin Zhu, Xinhao Wei, Yuxin Fang, Jiayi Zhu, Fei Gao, Guoqiang Dong, Shipeng He, Chunquan Sheng   +8 more
wiley   +1 more source

Protein Post-Translational Modifications in Plant Abiotic Stress Responses. [PDF]

Plants (Basel)
Li G, Feng B, Zhu QH, Jiang K, Zhang T.
europepmc   +1 more source