Results 111 to 120 of about 117,949 (359)

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling [PDF]

, 2014
Dishevelled (Dvl) is a key regulator of Wnt signaling both in the canonical and non-canonical pathways. Here we report the identification of a regulatory domain of ubiquitination (RDU) in the C-terminus of Dvl.
Cho, J-Y, Finley, D, Han, J-K, Han, W H, Jho, E-h, Jung, H, Kim, B-G, Lee, J H, Lee, M J, Maurice, M M, Park, W S   +10 more
core   +1 more source

Bioinspired Design of a Wet‐Adhesive Cornea Glue Based on Recombinant Human Protein Networks

Advanced Functional Materials, EarlyView.
Natures protein‐based high performance materials e.g. elastin, silk and muscle proteins have been mimicked by a new protein‐hybrid material based on redesigned human partial sequences only, showing high wet‐adhesiveness and elasticity for biomedical applications.
Anna Resch, Matthias C. Huber, Alexander Resch, Andreas Schreiber, Thabo Lapp, Jan Dittrich, Frederic Eisen, Austin Julian Michalec, Viktoria Planz, Adrianna Kolberg, Mathaeus Tschaikowsky, Daniel Böhringer, Maike Windbergs, Thomas Reinhard, Bernd Rolauffs, Bizan N. Balzer, Günther Schlunck, Stefan M. Schiller   +17 more
wiley   +1 more source

Different mechanisms that promote protein monoubiquitination [PDF]

, 2015
Protein monoubiquitination is a post-translational modificationthat consists of the conjugation of a single ubiquitin molecule to a target protein residue.
Crosas, Bernat, Puig-Sàrries, Pilar
core  

Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function [PDF]

, 2015
BRCC36 is a Zn²⁺-dependent deubiquitinating enzyme (DUB) that hydrolyzes lysine-63-linked ubiquitin chains as part of distinct macromolecular complexes that participate in either interferon signaling or DNA-damage recognition.
Alba Guarné, Albert J.R. Heck, Alexander F.A. Keszei, Ambroggio, Christopher A. Piggott, Cooper, Cooper, Derek F. Ceccarelli, Deshaies, Dong, Eletr, Elton Zeqiraj, Feng, Feng, Fitzgerald, Frank Sicheri, Gerald D. Gish, Gnad, Husnjak, Igor Kurinov, Kim, Komander, Komander, Kristina Lorenzen, Lavoie, Lei Tian, Lingaraju, Maytal-Kivity, Monica C. Pillon, Nicole M. Duffy, Nijman, Pathare, Patterson-Fortin, Rambo, Roger A. Greenberg, Sato, Sato, Shao, Sims, Sobhian, Stephen Orlicky, Svergun, Tran, Wang, Wang, Worden, Zheng   +46 more
core   +1 more source

The Expanding Universe of Ubiquitin and Ubiquitin-Like Modifiers [PDF]

Plant Physiology, 2012
The post-translation addition of ubiquitin (Ub) and structurally related polypeptide modifiers to other intracellular constituents is now known to be an important intermediate driving a wide assortment of metabolic and regulatory processes in plants. Although the most common targets are other proteins, conjugation of specific modifiers to lipids and ...
openaire   +3 more sources

Silencing Myostatin Using In Vivo Self‐Assembled siRNA Protects Against Cancer‐ and Dexamethasone‐Induced Muscle Atrophy

Advanced Healthcare Materials, EarlyView.
This study reports an in vivo self‐assembled siRNA strategy that enables the liver to generate small extracellular vesicles (sEVs) tagged with a muscle‐targeting peptide (MSP) and naturally loaded with myostatin (MSTN)‐siRNA. These MSP‐tagged sEVs are systemically delivered to skeletal muscle, efficiently silence MSTN, promote muscle hypertrophy, and ...
Xin Yin, Azhar Anwar, Jiehao Chen, Qinghao Sun, Likun Zhou, Jie Tang, Jingwei Guo, Linbo Yan, Yongci Chen, Feng Yin, Chen‐Yu Zhang, Zigang Li, Jizheng Ma, Liyuan Sheng, Xi Chen   +14 more
wiley   +1 more source

Biological applications of the theory of birth-and-death processes [PDF]

, 2005
In this review, we discuss the applications of the theory of birth-and-death processes to problems in biology, primarily, those of evolutionary genomics. The mathematical principles of the theory of these processes are briefly described.
Karev, Georgy P., Koonin, Eugene V., Novozhilov, Artem S.   +2 more
core  

Inhibition of the 26 S Proteasome by Polyubiquitin Chains Synthesized to Have Defined Lengths*

Journal of Biological Chemistry, 1997
Ubiquitin is a covalent signal that targets cellular proteins to the 26 S proteasome. Multiple ubiquitins can be ligated together through the formation of isopeptide bonds between Lys48 and Gly76 of successive ubiquitins.
J. Piotrowski, R. Beal, L. Hoffman, K. Wilkinson, R. E. Cohen, C. Pickart   +5 more
semanticscholar   +1 more source

Recombinant Proteins: A Molecular Tool to Understand Marine Adhesion and to Advance Biomaterials

Advanced Healthcare Materials, EarlyView.
The production of recombinant proteins represents a fundamental step in the characterisation of marine invertebrate adhesives and in the development of bio‐inspired glues. The association of these proteins with other components such as ions, proteins, polysaccharides, or polymers enables the fabrication of biomaterials for various healthcare ...
Alessandra Whaite, Emilie Duthoo, Mathilde Lefevre, Elise Hennebert, Patrick Flammang   +4 more
wiley   +1 more source