Results 151 to 160 of about 117,989 (312)

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Emerging tools and methods to study cell signalling mediated by branched ubiquitin chains. [PDF]

Biochem Soc Trans
McFarland MR, Kulathu Y.
europepmc   +1 more source

Structural Dynamics of Lys11-Selective Deubiquitinylase Cezanne-1 during the Catalytic Cycle. [PDF]

J Chem Inf Model, 2023
Ilter M, Schulze-Niemand E, Naumann M, Stein M.   +3 more
europepmc   +1 more source

Ubiquitin Lys63 is involved in ubiquitination of a yeast plasma membrane protein

EMBO Journal, 1997
J. Galan, R. Haguenauer‐Tsapis
semanticscholar   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Exploring Protein Misfolding in Amyotrophic Lateral Sclerosis: Structural and Functional Insights. [PDF]

Biomedicines
Ivantsik O, Exarchos TP, Vrahatis AG, Vlamos P, Krokidis MG.   +4 more
europepmc   +1 more source

Lysine 63-linked polyubiquitination is required for EGF receptor degradation

Proceedings of the National Academy of Sciences of the United States of America, 2013
Fangtian Huang, Xuemei Zeng, Woong Kim, M. Balasubramani, Arola Fortian, S. Gygi, N. Yates, A. Sorkin   +7 more
semanticscholar   +1 more source

TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux

Advanced Science, EarlyView.
TRIM38, an E3 ubiquitin ligase, suppresses breast cancer progression by inhibiting proliferation, migration, and invasion. Downregulated in breast tumor, its loss correlates with poor prognosis. Mechanistically, TRIM38 mediates K63‐linked ubiquitination of SQSTM1/p62 at K420, disrupting SQSTM1‐LC3 interaction and blocking autophagic flux.
Shan Jiang, Lijuan Wang, Dianwen Han, Peng Su, Bing Chen, Wenjing Zhao, Tong Chen, Ning Zhang, Xiaolong Wang, Yiran Liang, Yaming Li, Chen Li, Xi Chen, Dan Luo, Qifeng Yang   +14 more
wiley   +1 more source

A cut above: Bacterial deubiquitinases with ubiquitin clippase activity. [PDF]

Mol Cell
Hochstrasser M.
europepmc   +1 more source

Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice.

Journal of Clinical Investigation, 1996
T. Tsujinaka, J. Fujita, C. Ebisui, Masahiko Yano, E. Kominami, Koichi Suzuki, Keiji Tanaka, A. Katsume, Y. Ohsugi, H. Shiozaki, M. Monden   +10 more
semanticscholar   +1 more source