Results 171 to 180 of about 117,949 (359)

Red blood cells contain a pathway for the degradation of oxidant-damaged hemoglobin that does not require ATP or ubiquitin.

, 1986
Julie M. Fagan, Lloyd Waxman, Alfred L. Goldberg   +2 more
openalex   +1 more source

Novel diubiquitin probes expand the chemical toolkit to study DUBs [PDF]

, 2016
Borodovsky, Békés, Eletr, Flierman, McGouran, Mevissen, Mulder   +6 more
core   +2 more sources

Anticodon Engineered Transfer RNA (tRNASUAG) Inhibits Hepatitis B Virus Replication by Promoting the Degradation of Core Protein

Advanced Science, EarlyView.
This study employed tRNASUAG, an anticodon‐engineered tRNA (ACE‐tRNA), to introduce a phosphorylatable serine into the C‐terminal domain of HBc by reading through its stop codon, thereby potentially promoting the ubiquitin‐proteasome degradation of HBc, and subsequently inhibiting HBV replication. Through a tRNASUAG‐gHBV1‐tRNASUAG‐gHBV2‐tRNASUAG tandem
Xingwen Yang, Huiying Sun, Ziheng Luo, Qinxin Zhang, Yarong Song, Jie Li, Xiaoyun Liu, Jie Wang   +7 more
wiley   +1 more source

Complete reconstitution of conjugation and subsequent degradation of the tumor suppressor protein p53 by purified components of the ubiquitin proteolytic system [PDF]

, 1994
Dganit Shkedy, Hedva Gonen, Beatrice Bercovich, Aaron Ciechanover   +3 more
openalex   +1 more source

In vitro reconstitution defines the minimal requirements for Cdc48-dependent disassembly of the CMG helicase in budding yeast [PDF]

, 2019
Bell, Bodnar, Bodnar, Bodnar, Boh, Burgers, Costa, Davey, Deegan, Deng, Dewar, Dewar, Dewar, Dove, Duda, Ekkebus, Franz, Franz, Gambus, Harreman, Kelsall, Lammer, Liakopoulos, Maculins, Maric, Maric, Moreno, Morohashi, Saha, Schuberth, Scott, Sonneville, Stein, van den Boom, Vaz, Wu, Yuan   +36 more
core   +1 more source

STK25 Loss Augments Anti‐PD‐1 Therapy Efficacy by Regulating PD‐L1 Stability in Colorectal Cancer

Advanced Science, EarlyView.
This study demonstrates that STK25 depletion facilitates CRC immune escape through the inhibition of PD‐L1 Ser283 phosphorylation‐mediated ubiquitination, and promotes tumor growth. Furthermore, these findings identify STK25 as a potential therapeutic target to trigger antitumor immunity and promote immunotherapy efficacy. Abstract Tumor immune evasion
Xiaowen Qiao, Pu Xing, Hao Hao, Jiangbo Chen, Lin Song, Yifan Hou, Xinying Yang, Kai Weng, Jie Chen, Pin Gao, Tongkun Song, Hong Yang, Tianqi Liu, Yumeng Ran, Bo Chen, Wei Zhao, Jiabo Di, Zaozao Wang, Jun Zhang, Xiangqian Su, Beihai Jiang   +20 more
wiley   +1 more source

Conjugation of Ubiquitin to Proteins from Green Plant Tissues [PDF]

, 1991
Bjarke Veierskov, Ian B. Ferguson
openalex   +1 more source

The E3 ligase HOIL-1 catalyses ester bond formation between ubiquitin and components of the Myddosome in mammalian cells [PDF]

, 2019
Axel Knebel, Cohen, Ian R. Kelsall, J. Simon C. Arthur, Jiazhen Zhang, Philip Cohen, Thorne, Wang   +7 more
core   +2 more sources

Structural Dynamics of Lys11-Selective Deubiquitinylase Cezanne-1 during the Catalytic Cycle. [PDF]

J Chem Inf Model, 2023
Ilter M, Schulze-Niemand E, Naumann M, Stein M.   +3 more
europepmc   +1 more source

Histone Lactylation‐Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells

Advanced Science, EarlyView.
Glioblastoma (GBM) is the most aggressive primary brain tumor, with glioma stem cells (GSCs) driving treatment resistance. This study reveals that lactate promotes histone lactylation (H3K18la) at the VRK1 promoter, regulating GSC stemness and proliferation via the H3K18la/VRK1/YBX1/SOX2 pathway. The VRK1‐targeted nanoliposome A/TMZ‐siVRK1 demonstrates
Jinna Li, Chenyue Tang, Xuefeng Zhang, Rui Xing, Qing Guo   +4 more
wiley   +1 more source