Results 171 to 180 of about 33,989 (317)

Immunogold localisation of ubiquitin‐protein conjugates in Sf9 insect cells [PDF]

, 1993
Péter Lőw, F J Doherty, Miklós Sass, János Kovács, R. John Mayer, Lajos László   +5 more
openalex   +1 more source

NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis

Advanced Science, EarlyView.
Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong, Travis B. Lear, Ferhan Tuncer, John J. Villandre, Áine N. Boudreau, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Mads B. Larsen, Yun Hua, Yanwen Chen, Meigin E. Chandler, Ricardo Pineda, Simon M. Barratt‐Boyes, John W. Evankovich, Toren Finkel, Yuan Liu, Bill B. Chen   +18 more
wiley   +1 more source

Exploring Protein Misfolding in Amyotrophic Lateral Sclerosis: Structural and Functional Insights. [PDF]

Biomedicines
Ivantsik O, Exarchos TP, Vrahatis AG, Vlamos P, Krokidis MG.   +4 more
europepmc   +1 more source

Catalysis of non-canonical protein ubiquitylation by the ARIH1 ubiquitin ligase. [PDF]

Biochem J, 2023
Purser N, Tripathi-Giesgen I, Li J, Scott DC, Horn-Ghetko D, Baek K, Schulman BA, Alpi AF, Kleiger G.   +8 more
europepmc   +1 more source

Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins. [PDF]

, 1990
Wolfgang Seufert, Stefan Jentsch
openalex   +1 more source

The INAVA mRNA in Extracellular Vesicles Activates Normal Ovarian Fibroblasts by Phosphorylation–Ubiquitylation Crosstalk of HMGA2

Advanced Science, EarlyView.
Ovarian cancer‐derived extracellular vesicles (EVs) transfer INAVA mRNA to normal ovarian fibroblasts (NOFs). Translated INAVA protein inhibits HMGA2 phosphorylation‐dependent ubiquitylation and proteasomal degradation, promoting NOF activation.
Lingkai Gu, Zhangjin Shen, Shizhen Shen, Conghui Wang, Yuwan Liu, Xinyi Wei, Mengxia Zheng, Jiaxin Gu, Xiaojing Chen, Yi Sun, Junfen Xu, Yan Lu, Weiguo Lu   +12 more
wiley   +1 more source

Assembly of the 26 S complex that degrades proteins ligated to ubiquitin is accompanied by the formation of ATPase activity.

, 1990
T Armon, D Ganoth, Avram Hershko
openalex   +1 more source

The E3 Ubiquitin Ligase ARIH1 Facilitates Colorectal Cancer Progression by Promoting Oxidative Phosphorylation via the Mitochondrial Translocation of K63‐Linked Ubiquitinated PHB1

Advanced Science, EarlyView.
The RBR E3 ubiquitin ligase ARIH1, which is upregulated in colorectal cancer cells, promotes cell growth and metastasis and correlates with an unfavorable CRC prognosis. Mechanistically, ARIH1 catalyzes K63‐linked ubiquitination of PHB1, enhancing the interaction between PHB1 and Akt.
Ying Tong, Zhenling Wang, Yong Wang, Yang Chen, Hongqiang Zhang, Yunfei Lu, Lei Xu, Hengyang Shen, Changzhi Huang, Min Zhao, Wenjie Li, Shuai Wang, Yu Shao, Zan Fu   +13 more
wiley   +1 more source

Ubiquitin recruiting chimera: more than just a PROTAC. [PDF]

Biol Direct
Grigoreva TA, Novikova DS, Melino G, Barlev NA, Tribulovich VG.   +4 more
europepmc   +1 more source

Changes in ubiquitin and ubiquitin-protein conjugates in the CA1 neurons after transient sublethal ischemia

, 1991
Takashi Hayashi, Koji Takada, Makoto Matsuda   +2 more
openalex   +1 more source