Results 181 to 190 of about 117,989 (312)

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Author Correction: Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway. [PDF]

Nat Commun
Cooney I, Schubert HL, Cedeno K, Fisher ON, Carson R, Price JC, Hill CP, Shen PS.   +7 more
europepmc   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source

Age- and Sex-Dependent Variation in the Type I Interferon Signature of Healthy Individuals. [PDF]

Medicina (Kaunas)
Galliano I, Volpe M, Calvi C, Pavan M, Massobrio A, Gambarino S, Albiani R, Linari C, Clemente A, Pau A, Montanari P, Bergallo M.   +11 more
europepmc   +1 more source

Oxidative stress regulates the ubiquitin–proteasome system and immunoproteasome functioning in a mouse model of X-adrenoleukodystrophy [PDF]

, 2013
Nathalie Launay, Montserrat Ruíz, Stéphane Fourcade, Agatha Schlüter, Cristina Guilera, Isidró Ferrer, Erwin Knecht, Aurora Pujol   +7 more
openalex   +1 more source

The HECT ubiquitin-protein ligase (UPL) family in Arabidopsis: UPL3 has a specific role in trichome development.

The Plant Journal, 2003
B. Downes, R. Stupar, D. Gingerich, R. Vierstra   +3 more
semanticscholar   +1 more source

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

Advancing the Exploration of the Ubiquitin-like Protein FUBI with Synthetic Chemical Tools. [PDF]

Chembiochem
D'Amico F, Talavera Ormeño CMP, Poeran S, Akkermans J, Tjokrodirijo RTN, Sampadi B, van Veelen P, Sapmaz A, Mulder MPC.   +8 more
europepmc   +1 more source

Ubiquitin and Ubiquitin-Like Proteins in the Nucleolus: Multitasking Tools for a Ribosome Factory

, 2010
Natalia Shcherbik, Dimitri G. Pestov
openalex   +1 more source

A Rapid and Versatile Method for Generating Proteins with Defined Ubiquitin Chains.

Biochemistry, 2016
Kirby Martinez-Fonts, A. Matouschek
semanticscholar   +1 more source