Results 181 to 190 of about 33,989 (317)

The E3 ligase HOIL-1 catalyses ester bond formation between ubiquitin and components of the Myddosome in mammalian cells [PDF]

, 2019
Axel Knebel, Cohen, Ian R. Kelsall, J. Simon C. Arthur, Jiazhen Zhang, Philip Cohen, Thorne, Wang   +7 more
core   +2 more sources

Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8‐AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
PAX8‐AS1 drives chemoresistance in intrahepatic cholangiocarcinoma by activating NRF2‐mediated GPX4 transcription and stabilizing GPX4 mRNA via IGF2BP3. Targeting the PAX8‐AS1/GPX4 axis with a GPX4 inhibitor enhances the efficacy of gemcitabine and cisplatin in preclinical models, offering a promising strategy to overcome chemotherapy resistance in ...
Zhi‐Wen Chen, Ji‐Jun Shan, Mo Chen, Zong Wu, Yi‐Ming Zhao, Hong‐Xu Zhu, Xin Jin, Yi‐Xiu Wang, Yi‐Bin Wu, Zhen Xiang, Zhi‐Wen Ding, Zhen‐Hai Lin, Long‐Rong Wang, Lu Wang   +13 more
wiley   +1 more source

Cloning, bioinformatics analysis, and expression of the ubiquitin 2 (ubq-2) gene from the dog roundworm <i>Toxocara canis</i>. [PDF]

Front Vet Sci
Zhu P, Hu X, Huang J, Wang L, Wang Z, Wang R, Fan X, Wei G, He Q, Li Z, Zhou X, Wang H, Xie Y.   +12 more
europepmc   +1 more source

A Determination of p97/VCP (Valosin Containing Protein) and SVIP (Small VCP Interacting Protein) Expression Patterns in Human Testis. [PDF]

Medicina (Kaunas), 2023
Arıcı A, Erdemir F.
europepmc   +1 more source

The ubc-2 gene of Caenorhabditis elegans encodes a ubiquitin-conjugating enzyme involved in selective protein degradation.

, 1993
Mei Zhen, Ruth Heinlein, D. Stephen Charnock‐Jones, Stefan Jentsch, E. Peter M. Candido   +4 more
openalex   +1 more source

In vitro reconstitution defines the minimal requirements for Cdc48-dependent disassembly of the CMG helicase in budding yeast [PDF]

, 2019
Bell, Bodnar, Bodnar, Bodnar, Boh, Burgers, Costa, Davey, Deegan, Deng, Dewar, Dewar, Dewar, Dove, Duda, Ekkebus, Franz, Franz, Gambus, Harreman, Kelsall, Lammer, Liakopoulos, Maculins, Maric, Maric, Moreno, Morohashi, Saha, Schuberth, Scott, Sonneville, Stein, van den Boom, Vaz, Wu, Yuan   +36 more
core   +1 more source

Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis

Advanced Science, EarlyView.
Facet joint osteoarthritis (FJOA), prevalent in the elderly, involves Talin2 upregulation promoting ECM degradation while suppressing synthesis. Mechanical load stabilizes Talin2 via OTUB1‐mediated non‐canonical deubiquitination, driving CCL2 expression that recruits immune cells, exacerbating inflammatory joint degeneration.
Yizhen Huang, Heng Sun, Haojie Chen, Xiangpeng Wang, Junduo Zhao, Yang Jiao, Hongyi Zhou, Haoyu Cai, Jiafeng Dai, Xuan Huang, Weiyun Chen, Jianxiong Shen   +11 more
wiley   +1 more source

CUL1-neddylation contributes to K29-linked ubiquitination on p27 for autophagic degradation in sorafenib-resistant liver cancer. [PDF]

Cell Biol Toxicol
Xu H, Zheng S, Zhang Q, Xu Y, Zhang H, Hu T, Zhang X, E J, Li X, Wang R, Liu H, Xie R.   +11 more
europepmc   +1 more source

A human ubiquitin carboxyl extension protein functions in yeast.

, 1990
Brett P. Monia, David J. Ecker, Daniel Finley, Stanley T. Crooke   +3 more
openalex   +1 more source

The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase [PDF]

, 1990
Ian N.M. Day, L J Hinks, Richard J. Thompson   +2 more
openalex   +1 more source