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Structure and Evolution of Ubiquitin and Ubiquitin-Related Domains
2012Since its discovery over three decades ago, it has become abundantly clear that the ubiquitin (Ub) system is a quintessential feature of all aspects of eukaryotic biology. At the heart of the system lies the conjugation and deconjugation of Ub and Ub-like (Ubls) proteins to proteins or lipids drastically altering the biochemistry of the targeted ...
A. Maxwell Burroughs +2 more
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Monitoring MHC Ubiquitination by MARCH Ubiquitin Ligases
2019Ubiquitination is a reversible process that controls the intracellular transport of many transmembrane molecules. Ubiquitination of MHC I, MHC II, and CD1a by different members of the MARCH family of E3 ubiquitin ligases is a key event in the regulation of the potent immunostimulatory properties of activated dendritic cells. We describe here methods to
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Ubiquitin in autophagy and non-protein ubiquitination
Nature Structural & Molecular Biologyopenaire +2 more sources