Results 321 to 330 of about 33,702 (335)
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Ubiquitin and Ubiquitin-like Modifiers in Plants
Journal of Plant Biology, 2011Posttranslational modifications of proteins by small polypeptides including ubiquitination, neddylation (related to ubiquitin (RUB) conjugation), and sumoylation are implicated in plant growth and development, and they regulate protein degradation, location, and interaction with other proteins.
Hans J. Bohnert +5 more
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The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy
Trends in Biochemical Sciences, 2017The conjugation of the 76 amino acid protein ubiquitin to other proteins can alter the metabolic stability or non-proteolytic functions of the substrate. Once attached to a substrate (monoubiquitination), ubiquitin can itself be ubiquitinated on any of its seven lysine (Lys) residues or its N-terminal methionine (Met1).
Aaron Ciechanover +2 more
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Is This Protein Ubiquitinated?
2005Covalent modification of proteins with ubiquitin plays an important role in a wide array of cellular processes (Hershko and Ciechanover, 1998; Pickart, 2004). For this reason an increasing number of investigators in diverse research fields are confronted with the question whether their favorite proteins are ubiquitinated.
Christian Tagwerker, Peter K. Kaiser
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Targeting the monocytic ubiquitin system with extracellular ubiquitin
Immunology & Cell Biology, 2006Recent findings suggest that extracellular ubiquitin has pleiotropic effects on host defence mechanisms, but its cellular mechanism of action is not yet understood. Using fluorescence and in vivo confocal microscopy, we observed uptake of Nâterminal fluoresceinâlabelled ubiquitin into human PBMC and MonoMac 6 cells. Immunoblotting experiments indicated
Thomas Hirsch +2 more
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Trends in Biochemical Sciences, 2000
The ubiquitin-proteasome system fulfills an essential function in eukaryotes by controlling the levels of crucial intracellular regulatory proteins. In this system, a specific type of polyubiquitin chain acts as the proximal signal for targeting substrates to 26S proteasomes for degradation.
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The ubiquitin-proteasome system fulfills an essential function in eukaryotes by controlling the levels of crucial intracellular regulatory proteins. In this system, a specific type of polyubiquitin chain acts as the proximal signal for targeting substrates to 26S proteasomes for degradation.
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Ubiquitin adenylate: structure and role in ubiquitin activation
Biochemistry, 1983The acid precipitate of the ubiquitin activating enzyme after reaction with ATP and ubiquitin contains one enzyme equivalent of ubiquitin adenylate in which the carboxyl-terminal glycine of ubiquitin and AMP are in an acyl-phosphate linkage. The recovered ubiquitin adenylate has the catalytic properties proposed for it as a reaction intermediate. Thus,
Irwin A. Rose +2 more
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A ubiquitin and ubiquitin-like protein spectral library
PROTEOMICS, 2010We have developed and validated a ubiquitin (Ub) and ubiquitin-like protein (Ubl) spectral library, consisting of 467 consensus spectra (320 unique peptides derived from autophagy-related protein 8, F-adjacent transcript 10, interferon-stimulated gene 15 kDa protein, neural precursor cell expressed developmentally down-regulated protein 8, small ...
Srikumar, Tharan +3 more
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Structure and Evolution of Ubiquitin and Ubiquitin-Related Domains
2012Since its discovery over three decades ago, it has become abundantly clear that the ubiquitin (Ub) system is a quintessential feature of all aspects of eukaryotic biology. At the heart of the system lies the conjugation and deconjugation of Ub and Ub-like (Ubls) proteins to proteins or lipids drastically altering the biochemistry of the targeted ...
A. Maxwell Burroughs +2 more
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Monitoring MHC Ubiquitination by MARCH Ubiquitin Ligases
2019Ubiquitination is a reversible process that controls the intracellular transport of many transmembrane molecules. Ubiquitination of MHC I, MHC II, and CD1a by different members of the MARCH family of E3 ubiquitin ligases is a key event in the regulation of the potent immunostimulatory properties of activated dendritic cells. We describe here methods to
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