Results 41 to 50 of about 117,949 (359)
Ubiquitin carboxyl-terminal hydrolases are required for period maintenance of the circadian clock at high temperature in Arabidopsis [PDF]
, 2019 Protein ubiquitylation participates in a number of essential cellular processes including signal transduction and transcription, often by initiating the degradation of specific substrates through the 26S proteasome. Within the ubiquitin-proteasome system,
Coupland, George +6 more
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, 2019 Mutations in genes encoding PINK1 (PTEN-induced kinase 1) and Parkin (E3 ubiquitin ligase) are identified in familial Parkinson’s disease.
M. Pan +18 more
semanticscholar +1 more source
Regulation of endoplasmic reticulum-associated protein degradation (ERAD) by ubiquitin [PDF]
, 2014 Quality control of protein folding inside the endoplasmic reticulum (ER) includes chaperone-mediated assistance in folding and the selective targeting of terminally misfolded species to a pathway called ER-associated protein degradation, or simply ERAD.
Goder, Veit, Lemus Rodríguez,Leticia
core +2 more sources
Frontiers in Physiology, 2018 Structural and functional alterations of mitochondria are intimately linked to a wide array of medical conditions. Many factors are involved in the regulation of mitochondrial function, including cytokines, chaperones, chemokines, neurosteroids, and ...
Victoria O. Polyakova +10 more
doaj +1 more source
, 2011 In this chapter, we describe a method for detecting the ubiquitination status of G protein-coupled receptors (GPCRs). This involves co-expression of a GPCR with an epitope-tagged ubiquitin construct in a -heterologous mammalian expression system. Stimulus-dependent modification of the GPCR by -ubiquitin is detected by immunoprecipitation and subsequent
Adriano Marchese, Adriana Caballero
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Ubiquitin in Motion: Structural Studies of the Ubiquitin-Conjugating Enzyme∼Ubiquitin Conjugate [PDF]
Biochemistry, 2011 Ubiquitination of proteins provides a powerful and versatile post-translational signal in the eukaryotic cell. The formation of a thioester bond between ubiquitin (Ub) and the active site of a ubiquitin-conjugating enzyme (E2) is critical for the transfer of Ub to substrates. Assembly of a functional ubiquitin ligase (E3) complex poised for Ub transfer
Rachel E. Klevit +4 more
openaire +3 more sources
Frontiers in Microbiology, 2018 Ubiquitination is an essential protein modification in eukaryotic cells, which is reversible. Deubiquitinating enzymes (DUBs) catalyze deubiquitination process to reverse ubiquitination, maintain ubiquitin homeostasis or promote protein degradation by ...
Zhao Wang +5 more
doaj +1 more source
K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair
Science Signaling, 2018 Mutations in the DNA-interacting patch of ubiquitin sensitize cells to DNA-damaging agents. DNA-bound ubiquitin coordinates DNA repair Ubiquitylation is a posttranslational modification that reversibly alters protein stability, activity, interactions, or
Pengda Liu +9 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2018 Ever since the discovery of ubiquitin in 1975[...]
openaire +2 more sources
Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation [PDF]
, 2008 Conjugation of ubiquitin-like protein Nedd8 to cullins (neddylation) is essential for the function of cullin-RING ubiquitin ligases (CRLs). Here, we show that neddylation stimulates CRL activity by multiple mechanisms.
Deshaies, Raymond J., Saha, Anjanabha
core +1 more source