Rsp5 Ubiquitin Ligase Is Required for Protein Trafficking in Saccharomyces cerevisiae COPI Mutants [PDF]
, 2012 Retrograde trafficking from the Golgi to the endoplasmic reticulum (ER) depends on the formation of vesicles coated with the multiprotein complex COPI.
Jarmoszewicz, Katarzyna +3 more
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Frontiers in Plant Science, 2017 Drought stress from soil or air limits plant growth and development, leading to a reduction in crop productivity. Several E3 ligases positively or negatively regulate the drought stress response.
Sang-Wook Han +3 more
doaj +1 more source
Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy [PDF]
, 2017 p97 is a “segregase” that plays a key role in numerous ubiquitin (Ub)-dependent pathways such as ER-associated degradation. It has been hypothesized that p97 extracts proteins from membranes or macromolecular complexes to enable their proteasomal ...
Blythe, Emily E. +3 more
core +2 more sources
Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler
Nature Chemical Biology, 2020 Virtually all aspects of cell biology are regulated by a ubiquitin code where distinct ubiquitin chain architectures guide the binding events and itineraries of modified substrates.
Joanna Liwocha +15 more
semanticscholar +1 more source
A Ubiquitin-like Protein Unleashes Ubiquitin Ligases [PDF]
Cell, 2008 Modification of cullin-RING ubiquitin ligases by the ubiquitin-like molecule Nedd8 promotes substrate ubiquitination. A crystal structure of a cullin modified by Nedd8 recently reported in Cell (Duda et al., 2008) and a biochemical study in Molecular Cell (Saha and Deshaies, 2008) reveal the dramatic impact on the ligase machinery by conjugation of ...
Ning Zheng +2 more
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The laforin/malin E3-ubiquitin ligase complex ubiquitinates pyruvate kinase M1/M2 [PDF]
, 2015 [Background] Lafora disease (LD, OMIM 254780) is a fatal neurodegenerative disorder produced mainly by mutations in two genes: EPM2A, encoding the dual specificity phosphatase laforin, and EPM2B, encoding the E3-ubiquitin ligase malin.
Pablo Lujan, Pascual Sanz, Rosa Viana
core +1 more source
Notch signalling in cancer stem cells [PDF]
, 2009 [Abstract] A new theory about the development of solid tumours is emerging from the idea that solid tumours, like normal adult tissues, contain stem cells (called cancer stem cells) and arise from them. Genetic mutations encoding for proteins involved in
Aparicio Gallego, Guadalupe +4 more
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Molecular Genetics & Genomic Medicine, 2019 Background The observed mutations in cancer are the result of ~30 mutational processes, which stamp particular mutational signatures (MS). Nevertheless, it is still not clear which genomic alterations correlate to several MS.
Victor Trevino
doaj +1 more source
Molecular characterization and analysis of the acrB gene of Aspergillus nidulans: A gene identified by genetic interaction as a component of the regulatory network that includes the CreB deubiquitination enzyme [PDF]
, 2003 Copyright © 2003 by the Genetics Society of AmericaMutations in the acrB gene, which were originally selected through their resistance to acriflavine, also result in reduced growth on a range of sole carbon sources, including fructose, cellobiose ...
Adams, J. +4 more
core +1 more source
Using Ubiquitin Binders to Decipher the Ubiquitin Code [PDF]
Trends in Biochemical Sciences, 2019 Post-translational modifications (PTMs) by ubiquitin (Ub) are versatile, highly dynamic, and involved in nearly all aspects of eukaryote biological function. The reversibility and heterogeneity of Ub chains attached to protein substrates have complicated their isolation, quantification, and characterization.
Mattern M +4 more
openaire +3 more sources