Results 51 to 60 of about 33,989 (317)

Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling. [PDF]

, 2016
We have reported previously that activation of the MyD88-signaling network rapidly induces the formation of hybrid ubiquitin chains containing both Lys63-linked and Met1-linked ubiquitin (Ub) oligomers, some of which are attached covalently to ...
Boisson, Bosanac, Cheung, Christoph H. Emmerich, Clark, Draber, Dynek, Ea, Emmerich, Emmerich, Fiil, Gerlach, Gyrd-Hansen, Haas, Han, Hasegawa, Ian R. Kelsall, Juanma Ortiz-Guerrero, Kanayama, Keusekotten, Kirisako, Krieg, Kulathu, Lin, Lo, Lu, Masumoto, Matsumoto, Mevissen, Motshwene, Nanda, Natalia Shpiro, Pauls, Philip Cohen, Picard, Rahighi, Ritorto, Shim, Siddharth Bakshi, Skaug, Tokunaga, Tokunaga, Verhelst, Wang, Wertz, Wu, Xia, Ye, Zhang   +48 more
core   +2 more sources

Ubiquitin and Ubiquitin-Like Modifications of the p53 Family

Neoplasia, 2006
Regulation of p53 by the ubiquitin-proteasomal pathway has been studied considerably. Studies have also demonstrated that the ubiquitin-like proteins SUMO-1 and NEDD8 modify p53. Similarly, p63 and p73 are subject to regulation by ubiquitin and ubiquitin-like modifications, and perturbations of these pathways in the regulation of the p53 family have ...
Meredith S. Irwin, Ian R. Watson
openaire   +4 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Anthrax Toxin-Mediated Delivery of the Pseudomonas Exotoxin A Enzymatic Domain to the Cytosol of Tumor Cells via Cleavable Ubiquitin Fusions

mBio, 2013
Anthrax toxin proteins from Bacillus anthracis constitute a highly efficient system for delivering cytotoxic enzymes to the cytosol of tumor cells. However, exogenous proteins delivered to the cytosol of cells are subject to ubiquitination on lysines and
Christopher Bachran, Thomas Morley, Suzanne Abdelazim, Rasem J. Fattah, Shihui Liu, Stephen H. Leppla   +5 more
doaj   +1 more source

The Ubiquitin Binding Domain ZnF UBP Recognizes the C-Terminal Diglycine Motif of Unanchored Ubiquitin [PDF]

, 2006
SummaryUbiquitin binding proteins regulate the stability, function, and/or localization of ubiquitinated proteins. Here we report the crystal structures of the zinc-finger ubiquitin binding domain (ZnF UBP) from the deubiquitinating enzyme isopeptidase T
Cheng, Xiaodong, Heroux, Annie, Horton, John R., Mullally, James E., Reyes-Turcu, Francisca E., Wilkinson, Keith D.   +5 more
core   +1 more source

Ubiquitin ligases and beyond [PDF]

BMC Biology, 2012
In a review published in 2004 [1] and that still repays reading today, Cecile Pickart traced the evolution of research on ubiquitination from its origins in the proteasomal degradation of proteins through the revelation that it has a central role in cell cycle regulation and the recognition of regulatory roles for ubiquitin in intracellular membrane ...
Đikić, Ivan, Robertson, Miranda
openaire   +6 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Feces derived allergens of Tyrophagus putrescentiae reared on dried dog food and evidence of the strong nutritional interaction between the mite and Bacillus cereus producing protease bacillolysins and exo-chitinases

Frontiers in Physiology, 2016
Tyrophagus putrescentiae (Schrank, 1781) is an emerging source of allergens in stored products and homes. Feces proteases are the major allergens of astigmatid mites (Acari: Acaridida).
Tomas eErban, Dagmar eRybanska, Karel eHarant, Bronislava eHortova, Jan eHubert   +4 more
doaj   +1 more source

Ubiquitin and Ubiquitin-Like Proteins in Protein Regulation [PDF]

Circulation Research, 2007
The discovery of the ubiquitin system was awarded with the Nobel Prize in Chemistry in 2004. Labeling of intracellular proteins for degradation by a multienzymatic complex, called the proteasome, was identified as the main function of this system. Subsequently, it was discovered that the attachment of ubiquitin to proteins can modify their function ...
Joerg Herrmann, Amir Lerman, Lilach O. Lerman   +2 more
openaire   +2 more sources