Results 151 to 160 of about 23,719 (175)
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Ubiquitylation and Cancer Development
Current Cancer Drug Targets, 2008Ubiquitylation is an essential cellular process, and yet many cancer cells appear to be more reliant upon it than normal cells as they are surprisingly sensitive to proteasome inhibitors (PI) and proteasome inhibitor drugs are well tolerated in vivo.
Miasari, Maria. +2 more
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Ubiquitylation of Ion Channels
Physiology, 2005Ubiquitylation (i.e., covalent attachment of ubiquitin moieties to proteins) of ion channels allows regulation of their activity and fate. Nedd4/Nedd4-like ubiquitin-protein ligases bind to, ubiquitylate, and modulate the internalization of several channels bearing PY motifs, whereas endoplasmic reticulum-associated degradation (involving ...
Hugues, Abriel, Olivier, Staub
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Structural basis of ubiquitylation
Current Opinion in Structural Biology, 2002The attachment of the small protein ubiquitin to other proteins, a process known as ubiquitylation, is a widespread form of post-translational modification that regulates numerous cellular functions in eukaryotes. Ubiquitylation is performed by complexes of E2 and E3 enzymes that are assembled and select substrates via a series of protein-protein ...
Andrew P, VanDemark, Christopher P, Hill
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Protein Ubiquitylation and Synaptic Function
Annals of the New York Academy of Sciences, 2003Abstract: Conjugation of ubiquitin to proteins is a well‐established signal to regulate an ever expanding range of cellular processes. Here, we discuss recent findings that deeply link ubiquitin signaling to synaptic activity.
O. Cremona, COLLESI, CHIARA, E. Raiteri
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Science Signaling, 2016
A bacterial effector protein ubiquitylates host proteins through a mechanism that is independent of and blocks the host ubiquitylation machinery.
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A bacterial effector protein ubiquitylates host proteins through a mechanism that is independent of and blocks the host ubiquitylation machinery.
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Dimerization quality control via ubiquitylation
Science, 2018A specialized ubiquitin ligase enzyme approves only functional ...
Herhaus, Lina, Dikic, Ivan
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Ubiquitylation of the COMPASS component Swd2 links H2B ubiquitylation to H3K4 trimethylation
Nature Cell Biology, 2008Mono-ubiquitylation of histone H2B correlates with transcriptional activation and is required for di- and trimethylation at Lys 4 on the histone H3 tail (H3K4) by the SET1/COMPASS methyltransferase complex through a poorly characterized trans-tail pathway. Here we show that mono-ubiquitylation of histone H2B promotes ubiquitylation at Lys 68 and Lys 69
Vitaliano-Prunier, Adeline +5 more
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HACE1 Ubiquitylates Optineurin
Science Signaling, 2014The ubiquitylation of optineurin promotes autophagy and may contribute to the tumor suppressor function of the E3 ligase HACE1.
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Proteasomal recognition of ubiquitylated substrates
Trends in Plant Science, 2010Ubiquitin/26S proteasome-mediated proteolysis controls the half-life of numerous critical regulatory proteins and is an intimate regulatory component for nearly all aspects of cellular processes. In addition to ubiquitin conjugation, an additional level of substrate specificity is regulated at the step of proteasomal recognition of ubiquitylated ...
Hongyong, Fu +2 more
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H2B ubiquitylation and de-ubiquitylation in gene activation.
Novartis Foundation symposium, 2004Previous models for the role of histone modifications suggest that adding and removing modifications, such as acetylation/deacetylation in gene regulation, are functionally antagonistic. We have investigated a transcriptional role of H2B C-terminal ubiquitylation and de-ubiquitylation in Saccharomyces cerevisiae.
Anastasia, Wyce +2 more
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