Results 131 to 140 of about 29,730 (229)

Improving bioorthogonal protein ubiquitylation by click reaction

, 2013
Posttranslational modification of proteins with ubiquitin (ubiquitylation) regulates numerous cellular processes. Besides functioning as a signal for proteasomal degradation, ubiquitylation has also non-proteolytic functions by altering the biochemical ...
Schneider, Tatjana, Schneider, Daniel, Rösner, Daniel, Marx, Andreas, Scheffner, Martin   +4 more
core   +1 more source

Identification of E3 Ubiquitin Ligase Substrates Using Biotin Ligase-Based Proximity Labeling Approaches

Biomedicines
Ubiquitylation is a post-translational modification originally identified as the first step in protein degradation by the ubiquitin–proteasome system. Ubiquitylation is also known to regulate many cellular processes without degrading the ubiquitylated ...
Koji Matsuhisa, Shinya Sato, Masayuki Kaneko   +2 more
doaj   +1 more source

Ubiquitylomics:An Emerging Approach for Profiling Protein Ubiquitylation in Skeletal Muscle [PDF]

Skeletal muscle is a highly adaptable tissue, finely tuned by various physiological and pathological factors. Whilst the pivotal role of skeletal muscle in overall health is widely acknowledged, unravelling the underlying molecular mechanisms poses ...
Lord, Samuel O., Yu‐Chiang Lai, Johnston, Harvey E., Lai, Yu-Chiang; id_orcid, Rahul S. Samant, Samant, Rahul S., Samuel O. Lord, Harvey E. Johnston   +7 more
core   +1 more source

Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes [PDF]

, 2019
Ubiquitylation of outer mitochondrial membrane (OMM) proteins is closely related to the onset of familial Parkinson's disease. Typically, a reduction in the mitochondrial membrane potential results in Parkin‐mediated ubiquitylation of OMM proteins, which
コサコ, ヒデタカ, Fujiki, Yukio, フジキ, ユキオ, タナカ, ケイジ, Kosako, Hidetaka, Kimura, Mayumi, ヤマノ, コウジ, Kimura, Yoko, 小迫, 英尊, コヤノ, フミカ, 10291171, 301, Tanaka, Keiji, Koyano, Fumika, マツダ, ノリユキ, キムラ, マユミ, Yamano, Koji, Matsuda, Noriyuki, 172252/profile-ja.html, キムラ, ヨウコ   +19 more
core  

Decoding Chromatin Ubiquitylation: A Chemical Biology Perspective

Since Strahl and Allis proposed the "language of covalent histone modifications", a host of experimental studies have shed light on the different facets of chromatin regulation by epigenetic mechanisms.
Franz, Pauline, Fierz, Beat
core   +1 more source

Biotinylation Interferes with Protein Ubiquitylation and Turnover in Arabidopsis—A Cautionary Insight for Proximity Labeling in Ubiquitylation Proteome Studies

Nearly all eukaryotic proteins are turned over by the ubiquitin (Ub)-26S proteasome system (UPS). Despite its broad cellular roles, only a handful of UPS members, particularly the Ub E3 ligases that specifically recognize a protein for ubiquitylation ...
Peifeng Yu, Yang Li, Zhihua Hua
core   +1 more source

Ubiquitylation by the GID/CTLH complex regulates the metabolic and innate immune response of macrophages to infection by Mycobacterium tuberculosis. [PDF]

PLoS Pathog
Simwela NV, Johnston L, Sassetti CM, Russell DG.   +3 more
europepmc   +1 more source

A peroxiredoxin 1-reactive oxygen species feedback loop modulates nuclear factor kappa B activity in osteoclastogenesis. [PDF]

Mol Biomed
Lee H, Lee S, Jang YJ, Lee K, Hwang SY, Oh GT, Park JI, Yi SJ, Kim K.   +8 more
europepmc   +1 more source

The degrader gets degraded as cysteine fluctuates. [PDF]

Cell Chem Biol
Chen J, Xiao H.
europepmc   +1 more source

Proteome-wide Ubiquitinome Profiling Reveals Substrate-specific Dynamics Within the USP7 Network. [PDF]

Mol Cell Proteomics
Wolf van der Meer J, van der Knaap JA, Sijm A, Bezstarosti K, Dekkers DHW, Doff WAS, Demmers JAA, Verrijzer CP.   +7 more
europepmc   +1 more source