Results 111 to 120 of about 29,730 (229)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, Volume 20, Issue 10, Page 2449-2465, October 2026.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, Volume 20, Issue 10, Page 2466-2489, October 2026.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Hpo stabilises Sav by inhibiting Sav ubiquitylation.

, 2015
(A) Sav is stabilised when co-expressed with Hpo. Baseline Sav expression is increased upon proteasome inhibitor treatment (M/L). (B) hpo depletion by RNAi destabilises Sav protein levels.
Ieva Gailite (763016), Birgit L. Aerne (313544), David Sims (13878), Nicolas Tapon (270959)   +3 more
core   +1 more source

Ubiquitylation in normal and malignant hematopoiesis: novel therapeutic targets. [PDF]

, 2006
Contains fulltext : 51123.pdf (Publisher’s version ) (Open Access)The modification of proteins with ubiquitin is involved in the regulation of various important biological pathways.
B A van der Reijden, Reijden, B.A. van der, J H Jansen, Marteijn, J.A.F., Jansen, J.H., J A F Marteijn   +5 more
core   +2 more sources

Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation.

PLoS Genetics, 2011
Ubiquitylation targets proteins for proteasome-mediated degradation and plays important roles in many biological processes including apoptosis. However, non-proteolytic functions of ubiquitylation are also known. In Drosophila, the inhibitor of apoptosis
Tom V Lee, Yun Fan, Shiuan Wang, Mayank Srivastava, Meike Broemer, Pascal Meier, Andreas Bergmann   +6 more
doaj   +1 more source

Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Mesothelin overexpression activate important pathways like nuclear factor k‐light‐chain‐enhancer of activated B cells (NF‐κB) and interleukin‐6 (IL‐6). This in turn causes numerous cancers, such as pancreatic and ovarian cancers. MSLN‐targeting immunotherapies, like monoclonal antibodies, have shown efficacy.
Manoj Kumar Gupta, Ramakrishna Vadde, Ganji Purnachandra Nagaraju   +2 more
wiley   +1 more source

H2B Ubiquitylation Controls the Formation of Export-Competent mRNP.

, 2012
International audienceHistone H2B ubiquitylation is a transcription-dependent modification that not only regulates nucleosome dynamics but also controls the trimethylation of histone H3 on lysine 4 by promoting ubiquitylation of Swd2, a component of both
Holstege, Frank C P, Hérissant, Lucas, Dargemont, Catherine, Babour, Anna, Vitaliano-Prunier, Adeline, Gwizdek, Carole, Apponi, Luciano, Margaritis, Thanasis, Corbett, Anita H   +8 more
core   +1 more source

Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis

Journal of Integrative Plant Biology, Volume 68, Issue 10, Page 3569-3592, October 2026.
Plant phosphate (Pi) homeostasis relies on coordinated activities of the inositol polyphosphate kinases IPK1 and ITPK1, which balance localized InsP7 biosynthesis to control COP9 signalosome (CSN)‐dependent deneddylation of cullin 1 (CUL1). Perturbation of this equilibrium affects the stability of SPX4, a key negative regulator of phosphate starvation ...
Yashika Walia, Medha Noopur, Ishana Bhattacharya, Bhaskar Chandra Sahoo, Mritunjay Kasera, Naga Jyothi Pullagurla, Smritikana Dutta, Guizhen Liu, Gabriel Schaaf, Henning Jessen, Debabrata Laha, Souvik Bhattacharjee, Saikat Bhattacharjee   +12 more
wiley   +1 more source

Proteomic analyses reveal divergent ubiquitylation site patterns in murinetissues

, 2012
Posttranslational modifications of proteins increase the complexity of the cellular proteome andenable rapid regulation of protein functions in response to environmental changes.
Olsen, Jesper V, Beli, Petra, Choudhary, Chuna Ram, Wagner, Sebastian A, Young, Clifford, Weinert, Brian T, Kelstrup, Christian D, Schölz, Christian Friedhold, Nielsen, Michael Lund, Brakebusch, Cord   +9 more
core   +1 more source

Ubiquitylation and SUMOylation of Cardiac Ion Channels

, 2010
Cardiac ion channels play an essential role in the generation of the action potential of cardiomyocytes. Over the past 15 years, a new field of research called channelopathies has emerged; it regroups all diseases caused by ion channel dysfunction ...
Albesa, Maxime, Rougier, Jean-Sébastien, Abriel, Hugues   +2 more
core   +1 more source