Results 111 to 120 of about 28,143 (190)

Neuroendocrine tumours through an epigenetic lens: Emerging insights for diagnosis and treatment

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Neuroendocrine tumours (NETs) are well‐differentiated epithelial neuroendocrine neoplasms that frequently develop in the small intestine, pancreas, and lungs. NETs originate from neuroendocrine cells specialized in hormone secretion implicated in a number of physiological processes.
Victoria Jacquot, Benjamin Chevalier, Thomas Walter, Benjamin Gibert, Maria Ouzounova   +4 more
wiley   +1 more source

Ubiquitylation as a rheostat for TCR signaling: from targeted approaches towards global profiling.

Frontiers in Immunology, 2015
T cell receptor (TCR) signaling must be precisely tuned to limit collateral damage and prevent reactivity to self, while still allowing robust protective immune responses that control pathogen invasion.
Paula M Oliver, Claire eOleary, Emma eLewis   +2 more
doaj   +1 more source

Ligand‐induced ubiquitination regulates endocytosis and homeostasis of the ERECTA receptor kinase for stomatal development

New Phytologist, Volume 250, Issue 5, Page 3167-3181, June 2026.
Summary Stomatal patterning on the plant epidermis is regulated by the ERECTA family of leucine‐rich repeat receptor kinases (LRR‐RKs). While ubiquitination has emerged as a key regulatory mechanism for the endocytosis of receptor kinases, the precise molecular connections among ERECTA ubiquitination, endocytosis, and its biological functions remain ...
Liangliang Chen, Minh Huy Vu, Pengfei Bai, Alicia M. Cochran, Crystal F. Ying, Keiko U. Torii   +5 more
wiley   +1 more source

Targeted dephosphorylation of TFEB promotes its nuclear translocation

iScience
Summary: Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular responses to metabolic and other stresses. During nutrient replete and stressor-free conditions, phosphorylated TFEB is primarily localized to the cytoplasm ...
Jin-Feng Zhao, Natalia Shpiro, Gajanan Sathe, Abigail Brewer, Thomas J. Macartney, Nicola T. Wood, Florentina Negoita, Kei Sakamoto, Gopal P. Sapkota   +8 more
doaj   +1 more source

Reversible ubiquitylation in plant biology

, 2014
Reversible ubiquitylation plays an important regulatory role in almost all aspects of cellular and organismal processes in plants. Its pervasive regulatory role in plant biology is primarily due to the involvement of a large set of ubiquitin system ...
Pascal eGENSCHIK, Hongyong Fu, Pascal Genschik, Hongyong eFu, Daphne eGoring, Daphne R. Goring, Daphne Goring   +6 more
core   +1 more source

MAVS Ubiquitylation: Function, Mechanism, and Beyond

The mitochondrial antiviral-signaling protein (MAVS), a core adaptor protein in the retinoic-acid-inducible gene-I-like receptors (RLRs)-MAVS pathway, has been demonstrated to play an important role in antiviral immune response and tumor immunology ...
Jie Shen, Hongliang Dong
core   +1 more source

Multiple Mechanisms Confining RNA Polymerase II Ubiquitylation to Polymerases Undergoing Transcriptional Arrest

, 2005
SummaryIn order to study mechanisms and regulation of RNA polymerase II (RNAPII) ubiquitylation and degradation, highly purified factors were used to reconstitute RNAPII ubiquitylation in vitro.
Jesper Q. Svejstrup, Svejstrup, Jesper Q., Tempst, Paul, Søgaard, T. Max M., Somesh, Baggavalli P., Reid, James, Baggavalli P. Somesh, Liu, Wei-Feng, James Reid, T. Max M. Søgaard, Wei-Feng Liu, Erdjument-Bromage, Hediye, Hediye Erdjument-Bromage, Paul Tempst   +13 more
core   +1 more source

CENP-A Ubiquitylation Is Inherited through Dimerization between Cell Divisions

, 2016
SummaryThe presence of chromatin containing the histone H3 variant CENP-A dictates the location of the centromere in a DNA sequence-independent manner. But the mechanism by which centromere inheritance occurs is largely unknown.
Niikura, Yohei, Yohei Niikura, Kitagawa, Risa, Risa Kitagawa, Kitagawa, Katsumi, Katsumi Kitagawa   +5 more
core   +1 more source

Ubiquitylation in normal and malignant hematopoiesis: novel therapeutic targets.

, 2006
Contains fulltext : 51123.pdf (Publisher’s version ) (Open Access)The modification of proteins with ubiquitin is involved in the regulation of various important biological pathways.
B A van der Reijden, Reijden, B.A. van der, J H Jansen, Marteijn, J.A.F., Jansen, J.H., J A F Marteijn   +5 more
core   +1 more source

Ubiquitylation: its role and medical significance [PDF]

, 2015
Ubiquitylation is an intracellular chemical reaction in which the small polypeptide, ubiquitin, is covalently attached to proteins to serve as a versatile signal with proteolytic and non-proteolytic functions.
Boros, Imre Miklós, Deák Péter, Deák, Péter, Boros Imre M.   +3 more
core