Results 101 to 110 of about 29,730 (229)
The Journal of Physiology, EarlyView.Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney +4 more
wiley +1 more source
Assessing Ubiquitylation of Individual Proteins Using Xenopus Extract Systems.
, 2018 Xenopus extract systems have been used to study ubiquitylation of proteins, and to uncover some of the fundamental processes of the ubiquitylation pathway itself. They provide a simple, quick, and robust method for studying ubiquitylation.
core +2 more sources
Localization-Dependent and -Independent Roles of SLX4 in Regulating Telomeres
Cell Reports, 2013 SLX4, a scaffold for structure-specific DNA repair nucleases, is important for several types of DNA repair. Many repair proteins bind to sites of DNA damage, resulting in subnuclear “foci,” but SLX4 forms foci in human cells even without DNA damage ...
Jamie S.J. Wilson +5 more
doaj +1 more source
Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms
Medicinal Research Reviews, Volume 46, Issue 6, Page 1735-1752, November 2026.ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino +3 more
wiley +1 more source
Auto-ubiquitylation of LsRING.
E3 ubiquitin ligase activity of purified recombinant LsRING by auto-ubiquitylation. (TIF)
Yao Li (154923) +5 more
core +1 more source
CENP-A Ubiquitylation Is Inherited through Dimerization between Cell Divisions [PDF]
, 2016 SummaryThe presence of chromatin containing the histone H3 variant CENP-A dictates the location of the centromere in a DNA sequence-independent manner. But the mechanism by which centromere inheritance occurs is largely unknown.
Niikura, Yohei +5 more
core +1 more source
CMG helicase disassembly is essential and driven by two pathways in budding yeast
The EMBO JournalThe CMG helicase is the stable core of the eukaryotic replisome and is ubiquitylated and disassembled during DNA replication termination. Fungi and animals use different enzymes to ubiquitylate the Mcm7 subunit of CMG, suggesting that CMG ubiquitylation ...
Cristian Polo Rivera +2 more
doaj +1 more source
PINK1 regulated mitophagy is evident in skeletal muscles
Autophagy ReportsPINK1, mutated in familial forms of Parkinson’s disease, initiates mitophagy following mitochondrial depolarization. However, it is difficult to monitor this pathway physiologically in mice as loss of PINK1 does not alter basal mitophagy levels in most ...
Francois Singh +6 more
doaj +1 more source
UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis
Cell Reports, 2018 Summary: Genomic damage can feature DNA-protein crosslinks whereby their acute accumulation is utilized to treat cancer and progressive accumulation causes neurodegeneration.
Chunyan Liao +9 more
doaj +1 more source