Results 101 to 110 of about 28,143 (190)

Characteristics and Outcomes of Patients With Dedifferentiated Liposarcoma in a US Community Setting

Cancer Medicine, Volume 15, Issue 6, June 2026.
US community oncology patients with dedifferentiated liposarcoma have heterogeneous profiles, treatments, and outcomes. The poor survival rates in this population suggest an unmet need for better therapeutics. ABSTRACT Introduction Clinical characteristics and outcomes of patients treated for dedifferentiated liposarcoma (DDLPS) at community oncology ...
James E. Butrynski, Bal Nepal, Chenxiao Hu, Jinhong Guo, Jennifer Han, Lisa Herms, Alyssa B. Klein, Stephen Stanhope, Elizabeth L. Stanley, Karen Todoroff, Paul Conkling   +10 more
wiley   +1 more source

Investigation of MLKL ubiquitylation during necroptosis

, 2019
© 2019 Zikou LiuNecroptosis is one type of caspase 8-independent programmed cell death. Mixed lineage kinase domain-like (MLKL) is the essential terminal effector in the necroptosis signalling pathway.
Liu, Zikou
core  

H2B Ubiquitylation Controls the Formation of Export-Competent mRNP.

, 2012
International audienceHistone H2B ubiquitylation is a transcription-dependent modification that not only regulates nucleosome dynamics but also controls the trimethylation of histone H3 on lysine 4 by promoting ubiquitylation of Swd2, a component of both
Holstege, Frank C P, Hérissant, Lucas, Dargemont, Catherine, Babour, Anna, Vitaliano-Prunier, Adeline, Gwizdek, Carole, Apponi, Luciano, Margaritis, Thanasis, Corbett, Anita H   +8 more
core   +1 more source

TdT ubiquitylation inhibits its nucleotidyltransferase activity.

, 2012
(A) Ubiquitylation of TdT does not effect its DNA-binding property. His-TdT (180 ng) was incubated in the reaction in vitro ubiquitylation mixture with (lane 3) or without (lane 2) biotinylated ssDNA coupled to streptavidin–agarose.
Takuro Matsumoto (152830), Tomoyoshi Kato (152813), Sachiko Ando (152827), So Maezawa (152806), Kotaro Koiwai (152844), Osamu Koiwai (152848), Takahide Hayano (152836), Masahiro Suzuki (152839), Yoshihiro Nishiyama (152821), Rie Fukushima (152809), Toyofumi Matsushita (152811), Yoshiki Takagaki (152817), Kousuke Kouda (152833)   +12 more
core   +1 more source

GGAs: Regulation of Multiple Sorting Pathways and Potential Association With Human Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Golgi‐localized gamma‐ear‐containing Arf‐binding proteins (GGAs) are a family of monomeric clathrin adaptors that function in intracellular vesicle trafficking. The three GGA family members—GGA1, GGA2 and GGA3—were first identified as sorting adaptors almost simultaneously by independent research groups in 2000. It is now well established that
Qinqin Wang, Juan Mei, Shuyue Li, Guoan Zhang, Jian Qiu, Xuezhi Li   +5 more
wiley   +1 more source

BLAP-tags, TUBEs and DUB-Chips: Combined novel technologies will advance molecular epithelial physiology

Frontiers in Physiology, 2012
The field of ubiquitylation and dubiquitylation of proteins in molecular physiology is growing at a rapid rate. Our understanding of molecular physiology of these processes may become limited by the advancement of technologies that scientists can employ.
Kirk L Hamilton
doaj   +1 more source

Hpo stabilises Sav by inhibiting Sav ubiquitylation.

, 2015
(A) Sav is stabilised when co-expressed with Hpo. Baseline Sav expression is increased upon proteasome inhibitor treatment (M/L). (B) hpo depletion by RNAi destabilises Sav protein levels.
Ieva Gailite (763016), Birgit L. Aerne (313544), David Sims (13878), Nicolas Tapon (270959)   +3 more
core   +1 more source

Septins in the Middle—Makers and Breakers of Membrane Contact Sites

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Septins are a family of GTP‐binding proteins that assemble into heteromeric oligomers and polymers, associating with specific membrane domains and organelles according to their subunit composition. Growing evidence places septins at membrane contact sites (MCS) — key hubs for intracellular communication that mediate exchange of ions, lipids, and ...
TrishaJean J. Holt, Elias T. Spiliotis
wiley   +1 more source

Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses

Life Science Alliance
The E3 ubiquitin ligase RNF12/RLIM is mutated in intellectual disability and controls developmental gene expression. We show that chromatin targeting of RNF12 is required for substrate ubiquitylation and transcriptional responses, providing insight into ...
Carmen Espejo-Serrano, Catriona Aitken, Beatrice F Tan, Danielle G May, Rachel J Chrisopulos, Kyle J Roux, Jeroen AA Demmers, Samuel G Mackintosh, Joost Gribnau, Francisco Bustos, Cristina Gontan, Greg M Findlay   +11 more
doaj   +1 more source

Targeted disruption of linkage-specific ubiquitylation reveals a key role of K29-linked ubiquitylation in epigenome integrity [PDF]

Linkage-specific ubiquitin chains dictate the functional outcome of numerous critical ubiquitin-dependent signaling processes. However, the functions and targets of several poly-ubiquitin topologies remain poorly defined due to a paucity of tools for ...
Mund, A., Mailand, N., Jensen, L.J., Ingham, A., Isaakova, E., Völker-Albert, M., Arroyo-Gomez, J., Wang, J., Reverón-Gómez, N., Groth, A., Solis, V., Shearer, R.F., Guérillon, C., Weischenfeldt, K., Typas, D., Rahmanto, A.S., Koutrouli, M., Beli, P., Coscia, F., Mitrofanov, K., Schovsbo, S.   +20 more
core   +1 more source