Results 121 to 130 of about 29,730 (229)

Insights Into the Role of Lysine Acetylation of Non‐Histone Proteins in Plant Immunity

Plant, Cell &Environment, Volume 49, Issue 10, Page 7604-7618, October 2026.
ABSTRACT Plant immunity is regulated by numerous transcriptional and posttranslational mechanisms. Among these, lysine acetylation, which is controlled by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs), has been extensively studied, particularly in the context of epigenetic regulation through histone acetylation.
Jérémy Villette, Chloé Ilbert, Sébastien Aimé, Hoai‐Nam Truong, Marielle Adrian, Stéphane Bourque   +5 more
wiley   +1 more source

TdT ubiquitylation inhibits its nucleotidyltransferase activity.

, 2012
(A) Ubiquitylation of TdT does not effect its DNA-binding property. His-TdT (180 ng) was incubated in the reaction in vitro ubiquitylation mixture with (lane 3) or without (lane 2) biotinylated ssDNA coupled to streptavidin–agarose.
Takuro Matsumoto (152830), Tomoyoshi Kato (152813), Sachiko Ando (152827), So Maezawa (152806), Kotaro Koiwai (152844), Osamu Koiwai (152848), Takahide Hayano (152836), Masahiro Suzuki (152839), Yoshihiro Nishiyama (152821), Rie Fukushima (152809), Toyofumi Matsushita (152811), Yoshiki Takagaki (152817), Kousuke Kouda (152833)   +12 more
core   +1 more source

BLAP-tags, TUBEs and DUB-Chips: Combined novel technologies will advance molecular epithelial physiology

Frontiers in Physiology, 2012
The field of ubiquitylation and dubiquitylation of proteins in molecular physiology is growing at a rapid rate. Our understanding of molecular physiology of these processes may become limited by the advancement of technologies that scientists can employ.
Kirk L Hamilton
doaj   +1 more source

‘Candidatus Liberibacter asiaticus’ secretory protein SDE5640 activates host autophagy dependent on PSMD10 to mediate PBA1 degradation

The Plant Journal, Volume 128, Issue 1, October 2026.
Significance Statement In healthy citrus cells, CsPSMD10 directly binds CsATG8 and targets it for ubiquitin‐dependent degradation by the intact 26S proteasome, maintaining low free CsATG8 levels and suppressing autophagy to preserve immune homeostasis.
Yalin Mei, Xinyi Deng, Zaiyu Yang, Shimin Fu, Changyong Zhou, Xuefeng Wang   +5 more
wiley   +1 more source

Targeted disruption of linkage-specific ubiquitylation reveals a key role of K29-linked ubiquitylation in epigenome integrity [PDF]

Linkage-specific ubiquitin chains dictate the functional outcome of numerous critical ubiquitin-dependent signaling processes. However, the functions and targets of several poly-ubiquitin topologies remain poorly defined due to a paucity of tools for ...
Mund, A., Mailand, N., Jensen, L.J., Ingham, A., Isaakova, E., Völker-Albert, M., Arroyo-Gomez, J., Wang, J., Reverón-Gómez, N., Groth, A., Solis, V., Shearer, R.F., Guérillon, C., Weischenfeldt, K., Typas, D., Rahmanto, A.S., Koutrouli, M., Beli, P., Coscia, F., Mitrofanov, K., Schovsbo, S.   +20 more
core   +1 more source

Targeted dephosphorylation of SMAD3 as an approach to impede TGF-β signaling

iScience
Summary: TGF-β (transforming growth factor-β) signaling is involved in a myriad of cellular processes and its dysregulation has been implicated in many human diseases, including fibrosis and cancer.
Abigail Brewer, Jin-Feng Zhao, Rotimi Fasimoye, Natalia Shpiro, Thomas J. Macartney, Nicola T. Wood, Melanie Wightman, Dario R. Alessi, Gopal P. Sapkota   +8 more
doaj   +1 more source

Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses

Life Science Alliance
The E3 ubiquitin ligase RNF12/RLIM is mutated in intellectual disability and controls developmental gene expression. We show that chromatin targeting of RNF12 is required for substrate ubiquitylation and transcriptional responses, providing insight into ...
Carmen Espejo-Serrano, Catriona Aitken, Beatrice F Tan, Danielle G May, Rachel J Chrisopulos, Kyle J Roux, Jeroen AA Demmers, Samuel G Mackintosh, Joost Gribnau, Francisco Bustos, Cristina Gontan, Greg M Findlay   +11 more
doaj   +1 more source

MAVS Ubiquitylation: Function, Mechanism, and Beyond

The mitochondrial antiviral-signaling protein (MAVS), a core adaptor protein in the retinoic-acid-inducible gene-I-like receptors (RLRs)-MAVS pathway, has been demonstrated to play an important role in antiviral immune response and tumor immunology ...
Jie Shen, Hongliang Dong
core   +1 more source

Ubiquitylation: its role and medical significance [PDF]

, 2015
Ubiquitylation is an intracellular chemical reaction in which the small polypeptide, ubiquitin, is covalently attached to proteins to serve as a versatile signal with proteolytic and non-proteolytic functions.
Boros, Imre Miklós, Deák Péter, Deák, Péter, Boros Imre M.   +3 more
core  

Targeted dephosphorylation of TFEB promotes its nuclear translocation

iScience
Summary: Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular responses to metabolic and other stresses. During nutrient replete and stressor-free conditions, phosphorylated TFEB is primarily localized to the cytoplasm ...
Jin-Feng Zhao, Natalia Shpiro, Gajanan Sathe, Abigail Brewer, Thomas J. Macartney, Nicola T. Wood, Florentina Negoita, Kei Sakamoto, Gopal P. Sapkota   +8 more
doaj   +1 more source