Results 121 to 130 of about 28,143 (190)

Improving bioorthogonal protein ubiquitylation by click reaction

, 2013
Posttranslational modification of proteins with ubiquitin (ubiquitylation) regulates numerous cellular processes. Besides functioning as a signal for proteasomal degradation, ubiquitylation has also non-proteolytic functions by altering the biochemical ...
Schneider, Tatjana, Schneider, Daniel, Rösner, Daniel, Marx, Andreas, Scheffner, Martin   +4 more
core   +1 more source

Identification of E3 Ubiquitin Ligase Substrates Using Biotin Ligase-Based Proximity Labeling Approaches

Biomedicines
Ubiquitylation is a post-translational modification originally identified as the first step in protein degradation by the ubiquitin–proteasome system. Ubiquitylation is also known to regulate many cellular processes without degrading the ubiquitylated ...
Koji Matsuhisa, Shinya Sato, Masayuki Kaneko   +2 more
doaj   +1 more source

A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

, 2011
Post-translational modification of proteins by ubiquitin is a fundamentally important regulatory mechanism. However, proteome-wide analysis of endogenous ubiquitylation remains a challenging task, and almost always has relied on cells expressing affinity
Weinert, Brian Tate, Wagner, S. A., Michael L. Nielsen, Chunaram Choudhary, Mann, M., Matthias Mann, Jürgen Cox, Nielsen, Michael Lund, Cox, Jürgen, Weinert, B., Choudhary, C., Mann, Matthias, Nielsen, M. L., Wagner, S., Weinert, B. T., Beli, Petra, Choudhary, Chuna Ram, Sebastian A. Wagner, Wagner, Sebastian Alexander, Beli, P., Petra Beli, Nielsen, M., Cox, J., Brian T. Weinert   +23 more
core   +1 more source

RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells.

, 2009
H2B ubiquitylation has been implicated in active transcription but is not well understood in mammalian cells. Beyond earlier identification of hBRE1 as the E3 ligase for H2B ubiquitylation in human cells, we now show (1) that hRAD6 serves as the cognate ...
Tang, Zhanyun, Shilatifard, Ali, Muir, T.W., Guermah, M, McGinty, RK, Kim, Jaehoon, Muir, TW, Milne, Thomas A., Shilatifard, A., Guermah, Mohamed, McGinty, Robert K., Tang, Z., Lee, J.-S., Milne, T.A., Roeder, R.G., Shilatifard, A, Milne, TA, Lee, Jung-Shin, Roeder, Robert G., Muir, Tom W., McGinty, R.K., Tang, Z, Guermah, M., Kim, J, Kim, J., Roeder, RG, Lee, JS   +26 more
core   +1 more source

Decoding Chromatin Ubiquitylation: A Chemical Biology Perspective

Since Strahl and Allis proposed the "language of covalent histone modifications", a host of experimental studies have shed light on the different facets of chromatin regulation by epigenetic mechanisms.
Franz, Pauline, Fierz, Beat
core   +1 more source

Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes [PDF]

, 2019
Ubiquitylation of outer mitochondrial membrane (OMM) proteins is closely related to the onset of familial Parkinson's disease. Typically, a reduction in the mitochondrial membrane potential results in Parkin‐mediated ubiquitylation of OMM proteins, which
コサコ, ヒデタカ, Fujiki, Yukio, フジキ, ユキオ, タナカ, ケイジ, Kosako, Hidetaka, Kimura, Mayumi, ヤマノ, コウジ, Kimura, Yoko, 小迫, 英尊, コヤノ, フミカ, 10291171, 301, Tanaka, Keiji, Koyano, Fumika, マツダ, ノリユキ, キムラ, マユミ, Yamano, Koji, Matsuda, Noriyuki, 172252/profile-ja.html, キムラ, ヨウコ   +19 more
core  

Ubiquitylation and Deubiquitylation in Health and Diseases. [PDF]

Biomedicines
Nakagawa T.
europepmc   +1 more source

Cysteine availability tunes ubiquitin signaling via inverse stability of LRRC58 E3 ligase and its substrate CDO1. [PDF]

Nat Commun
Andree GA, Stier LJ, Schmiederer K, Thielen AS, Schmid L, Maiwald SA, Gottemukkala KV, Du J, von Gronau S, Strasser C, Müller J, Henneberg LT, Guyot C, Kleiger G, Mann M, Murray PJ, Schulman BA.   +16 more
europepmc   +1 more source

Correction: Knockdown of MSI2 inhibits metastasis by interacting with caveolin-1 and inhibiting its ubiquitylation in human NF1-MPNST cells. [PDF]

Cell Death Dis
Yang K, Du J, Shi D, Ji F, Ji Y, Pan J, Lv F, Zhang Y.   +7 more
europepmc   +1 more source

Ubiquitylation of DNA polymerase β via atypical K27 chains signals a DNA damage response. [PDF]

Nucleic Acids Res
Fang Q, Koczor CA, Roos WP, McClellan S, Andrews JF, Sobol RW.   +5 more
europepmc   +1 more source